Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes

Hypoxia initiates pulmonary vasoconstriction (HPV) by inhibiting one or more voltage-gated potassium channels (Kv) in the pulmonary artery smooth muscle cells (PASMCs) of resistance arteries. The resulting membrane depolarization increases opening of voltage-gated calcium channels, raising cytosolic...

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Veröffentlicht in:	The Journal of clinical investigation Jg. 101; H. 11; S. 2319
Hauptverfasser:	Archer, S L, Souil, E, Dinh-Xuan, A T, Schremmer, B, Mercier, J C, El Yaagoubi, A, Nguyen-Huu, L, Reeve, H L, Hampl, V
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.06.1998
Schlagworte:	Animals Antibody Specificity Calcium - metabolism Delayed Rectifier Potassium Channels Hypoxia - physiopathology Immunoblotting Immunohistochemistry Kv1.5 Potassium Channel Male Membrane Potentials Mice Muscle, Smooth, Vascular - physiology Potassium Channels - genetics Potassium Channels - physiology Potassium Channels, Voltage-Gated Pulmonary Artery - physiology Rats Rats, Sprague-Dawley Shab Potassium Channels Vasoconstriction
ISSN:	0021-9738
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