Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent

Statement of problem. Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be detrimental to patients undergoing radiation therapy for head and neck cancer, to some immunocompromised patients, to families w...

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Vydané v:	The Journal of prosthetic dentistry Ročník 80; číslo 6; s. 685 - 690
Hlavní autori:	Eldridge, Kathrine R., Finnie, Sonja F., Stephens, Joni A., Mauad, Amable M., Munoz, Carlos A., Kettering, James D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.12.1998
Predmet:	Adult Analysis of Variance Anti-Infective Agents, Local - therapeutic use Chlorhexidine - analogs & derivatives Chlorhexidine - therapeutic use Dental Plaque Index Double-Blind Method Drug Combinations Ethanol Female Humans Male Mouthwashes - therapeutic use Oils, Volatile - therapeutic use Pilot Projects Salicylates - therapeutic use Streptococcus mutans - drug effects Streptococcus mutans - isolation & purification Terpenes - therapeutic use Time Factors
ISSN:	0022-3913, 1097-6841
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Abstract	Statement of problem. Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be detrimental to patients undergoing radiation therapy for head and neck cancer, to some immunocompromised patients, to families with small children, and to persons sensitive to alcohol. Purpose. This study evaluated the effectiveness of alcohol-free, 0.12% chlorhexidine mouthrinse in reducing microbial levels when compared with commercially available 0.12% chlorhexidine (CHX) and essential oils mouthrinses. Material and methods. This study consisted of both in vitro and in vivo investigations. The double-blind study included 32 subjects randomly assigned to 3 groups, equalized according to the indices tested. One group (n = 11) received essential oils rinse; the second group (n = 11) received CHX; and the last group (n = 10) received the alcohol-free CHX. Subjects were asked not to use any mechanical means of oral hygiene for 21 days. The in vitro part of the study consisted of Streptococcus mutans strip tests. Results. Mean plaque scores for both CHX products decreased after 21 days, whereas the mean for the essential oils increased. Bleeding and gingival index scores for all 3 groups increased, which may be due to the initially healthy tissues of the participants. Relative microbial growth for S mutans for both the CHX products decreased to 0 after 21 days, whereas the counts for the essential oils group remained varied.(J Prosthet Dent 1998;80:685-90.)
AbstractList	Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be detrimental to patients undergoing radiation therapy for head and neck cancer, to some immunocompromised patients, to families with small children, and to persons sensitive to alcohol.STATEMENT OF PROBLEMAntimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be detrimental to patients undergoing radiation therapy for head and neck cancer, to some immunocompromised patients, to families with small children, and to persons sensitive to alcohol.This study evaluated the effectiveness of alcohol-free, 0.12% chlorhexidine mouthrinse in reducing microbial levels when compared with commercially available 0.12% chlorhexidine (CHX) and essential oils mouthrinses.PURPOSEThis study evaluated the effectiveness of alcohol-free, 0.12% chlorhexidine mouthrinse in reducing microbial levels when compared with commercially available 0.12% chlorhexidine (CHX) and essential oils mouthrinses.This study consisted of both in vitro and in vivo investigations. The double-blind study included 32 subjects randomly assigned to 3 groups, equalized according to the indices tested. One group (n = 11) received essential oils rinse; the second group (n = 11) received CHX; and the last group (n = 10) received the alcohol-free CHX. Subjects were asked not to use any mechanical means of oral hygiene for 21 days. The in vitro part of the study consisted of Streptococcus mutans strip tests.MATERIAL AND METHODSThis study consisted of both in vitro and in vivo investigations. The double-blind study included 32 subjects randomly assigned to 3 groups, equalized according to the indices tested. One group (n = 11) received essential oils rinse; the second group (n = 11) received CHX; and the last group (n = 10) received the alcohol-free CHX. Subjects were asked not to use any mechanical means of oral hygiene for 21 days. The in vitro part of the study consisted of Streptococcus mutans strip tests.Mean plaque scores for both CHX products decreased after 21 days, whereas the mean for the essential oils increased. Bleeding and gingival index scores for all 3 groups increased, which may be due to the initially healthy tissues of the participants. Relative microbial growth for S mutans for both the CHX products decreased to 0 after 21 days, whereas the counts for the essential oils group remained varied.RESULTSMean plaque scores for both CHX products decreased after 21 days, whereas the mean for the essential oils increased. Bleeding and gingival index scores for all 3 groups increased, which may be due to the initially healthy tissues of the participants. Relative microbial growth for S mutans for both the CHX products decreased to 0 after 21 days, whereas the counts for the essential oils group remained varied. Statement of problem. Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be detrimental to patients undergoing radiation therapy for head and neck cancer, to some immunocompromised patients, to families with small children, and to persons sensitive to alcohol. Purpose. This study evaluated the effectiveness of alcohol-free, 0.12% chlorhexidine mouthrinse in reducing microbial levels when compared with commercially available 0.12% chlorhexidine (CHX) and essential oils mouthrinses. Material and methods. This study consisted of both in vitro and in vivo investigations. The double-blind study included 32 subjects randomly assigned to 3 groups, equalized according to the indices tested. One group (n = 11) received essential oils rinse; the second group (n = 11) received CHX; and the last group (n = 10) received the alcohol-free CHX. Subjects were asked not to use any mechanical means of oral hygiene for 21 days. The in vitro part of the study consisted of Streptococcus mutans strip tests. Results. Mean plaque scores for both CHX products decreased after 21 days, whereas the mean for the essential oils increased. Bleeding and gingival index scores for all 3 groups increased, which may be due to the initially healthy tissues of the participants. Relative microbial growth for S mutans for both the CHX products decreased to 0 after 21 days, whereas the counts for the essential oils group remained varied.(J Prosthet Dent 1998;80:685-90.) Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be detrimental to patients undergoing radiation therapy for head and neck cancer, to some immunocompromised patients, to families with small children, and to persons sensitive to alcohol. This study evaluated the effectiveness of alcohol-free, 0.12% chlorhexidine mouthrinse in reducing microbial levels when compared with commercially available 0.12% chlorhexidine (CHX) and essential oils mouthrinses. This study consisted of both in vitro and in vivo investigations. The double-blind study included 32 subjects randomly assigned to 3 groups, equalized according to the indices tested. One group (n = 11) received essential oils rinse; the second group (n = 11) received CHX; and the last group (n = 10) received the alcohol-free CHX. Subjects were asked not to use any mechanical means of oral hygiene for 21 days. The in vitro part of the study consisted of Streptococcus mutans strip tests. Mean plaque scores for both CHX products decreased after 21 days, whereas the mean for the essential oils increased. Bleeding and gingival index scores for all 3 groups increased, which may be due to the initially healthy tissues of the participants. Relative microbial growth for S mutans for both the CHX products decreased to 0 after 21 days, whereas the counts for the essential oils group remained varied.
Author	Finnie, Sonja F. Munoz, Carlos A. Eldridge, Kathrine R. Mauad, Amable M. Stephens, Joni A. Kettering, James D.
Author_xml	– sequence: 1 givenname: Kathrine R. surname: Eldridge fullname: Eldridge, Kathrine R. – sequence: 2 givenname: Sonja F. surname: Finnie fullname: Finnie, Sonja F. – sequence: 3 givenname: Joni A. surname: Stephens fullname: Stephens, Joni A. – sequence: 4 givenname: Amable M. surname: Mauad fullname: Mauad, Amable M. – sequence: 5 givenname: Carlos A. surname: Munoz fullname: Munoz, Carlos A. – sequence: 6 givenname: James D. surname: Kettering fullname: Kettering, James D.
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Cites_doi	10.1902/jop.1965.36.3.177 10.14219/jada.archive.1985.0422 10.3109/00016356309011240 10.1902/jop.1970.41.41.41 10.1093/oxfordjournals.aje.a008886 10.1111/j.1600-0765.1995.tb01273.x 10.1016/S0002-8177(86)24021-0 10.1093/jnci/85.6.465 10.1016/S0002-8177(94)14003-3 10.1902/jop.1959.30.1.51 10.1177/00220345850640111601 10.1002/jctb.5010030205 10.1111/j.1600-051X.1990.tb01108.x 10.1093/jnci/83.11.751 10.1177/00220345820610101501 10.1111/j.1754-4505.1993.tb01468.x 10.1177/00220345820610091101 10.1016/S0002-8177(94)14001-X 10.1016/S0002-8177(94)14004-5
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Copyright	1998 Editorial Council of The Journal of Prosthetic Dentistry.
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publication-title: J Am Dent Assoc doi: 10.1016/S0002-8177(94)14004-5
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Snippet	Statement of problem. Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been... Antimicrobial mouthrinses have become an important part of comprehensive dental care. However, mouthrinses that contain alcohol have been shown to be...
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SubjectTerms	Adult Analysis of Variance Anti-Infective Agents, Local - therapeutic use Chlorhexidine - analogs & derivatives Chlorhexidine - therapeutic use Dental Plaque Index Double-Blind Method Drug Combinations Ethanol Female Humans Male Mouthwashes - therapeutic use Oils, Volatile - therapeutic use Pilot Projects Salicylates - therapeutic use Streptococcus mutans - drug effects Streptococcus mutans - isolation & purification Terpenes - therapeutic use Time Factors
Title	Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent
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