Effects of food and ethnicity on the pharmacokinetics of venadaparib, a next-generation PARP inhibitor, in healthy Korean, Caucasian, and Chinese male subjects

Aim Venadaparib is a next-generation poly(ADP-ribose) polymerase inhibitor under development for treating gastric cancer. This study aimed to evaluate the effects of food and ethnicity on the pharmacokinetics (PKs) and safety of venadaparib after a single oral administration in healthy Korean, Cauca...

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Veröffentlicht in:	Investigational new drugs Jg. 42; H. 1; S. 80 - 88
Hauptverfasser:	Kim, Hyun Chul, Yang, Eunsol, Lee, Soyoung, Oh, Jaeseong, Lee, Myongjae, Lee, ChaeEun, Ha, Kyoung Soo, Lee, Won Sik, Jang, In-Jin, Yu, Kyung-Sang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.02.2024 Springer Nature B.V
Schlagworte:	Dosage Ethnicity Food Gastric cancer Inhibitors Labels Males Medicine Medicine & Public Health Minority & ethnic groups Oncology Oral administration Pharmacokinetics Pharmacology/Toxicology Poly(ADP-ribose) Poly(ADP-ribose) polymerase Ribose Statistical analysis Targeted cancer therapy Time measurement White people Ethnic effect Food effect Pharmacokinetics PARP inhibitor Venadaparib
ISSN:	0167-6997, 1573-0646, 1573-0646
Online-Zugang:	Volltext
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