ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer

Review evaluates the possible physiological roles of MDR‐related ABC transporters on immune effector cells based on reports on their expression patterns and immune‐related substrates. ABC transporters were identified originally for their contribution to clinical MDR as a result of their capacity to...

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Published in:Journal of leukocyte biology Vol. 86; no. 5; pp. 1075 - 1087
Main Authors: Ven, Rieneke, Oerlemans, Ruud, Heijden, Joost W., Scheffer, George L., Gruijl, Tanja D., Jansen, Gerrit, Scheper, Rik J.
Format: Journal Article
Language:English
Published: United States Society for Leukocyte Biology 01.11.2009
Subjects:
Antineoplastic Agents - therapeutic use
ATP-Binding Cassette Transporters - immunology
ATP-Binding Cassette Transporters - physiology
autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Autoimmunity - drug effects
Autoimmunity - genetics
drug resistance
Drug Resistance, Neoplasm - drug effects
Drug Resistance, Neoplasm - genetics
Drug Resistance, Neoplasm - immunology
Humans
immune system
Immunity - drug effects
Immunity - genetics
immunotherapy
Immunotherapy - methods
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - immunology
ISSN:0741-5400, 1938-3673, 1938-3673
Online Access:Get full text
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Summary:Review evaluates the possible physiological roles of MDR‐related ABC transporters on immune effector cells based on reports on their expression patterns and immune‐related substrates. ABC transporters were identified originally for their contribution to clinical MDR as a result of their capacity to extrude various unrelated cytotoxic drugs. More recent reports have shown that ABC transporters can play important roles in the development, differentiation, and maturation of immune cells and are involved in migration of immune effector cells to sites of inflammation. Many of the currently identified, endogenous ABC transporter substrates have immunostimulating effects. Increasing the expression of ABC transporters on immune cells and thereby enhancing immune cell development or functionality may be beneficial to immunotherapy in the field of oncology. On the contrary, in the treatment of autoimmune diseases, blockade of these transporters may prove beneficial, as it could dampen disease activity by compromising immune effector cell functions. This review will focus on the expression, regulation, and substrate specificity of ABC transporters in relation to functional activities of immune effector cells and discusses implications for the treatment of cancer on the one hand and autoimmune diseases on the other.
Bibliography:These authors contributed equally to this work.
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ISSN:0741-5400
1938-3673
1938-3673
DOI:10.1189/jlb.0309147