Does at‐home bleaching induce systemic oxidative stress in healthy subjects?
Background At‐home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth‐whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at‐home bleaching on serum redox home...
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| Vydáno v: | Australian dental journal Ročník 62; číslo 1; s. 58 - 64 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Australia
01.03.2017
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| ISSN: | 0045-0421, 1834-7819, 1834-7819 |
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| Abstract | Background
At‐home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth‐whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at‐home bleaching on serum redox homeostasis.
Methods
Twenty‐nine healthy volunteers who requested tooth‐whitening participated in this study. Specified bleaching trays were fabricated for the maxilla and mandible arches. Each participant was given two syringes containing 9% hydrogen peroxide gel to use for 30 min/night for 14 nights consecutively. To evaluate the redox status, the serum concentrations of malondialdehyde (MDA), total antioxidant capacity (TAC) and pro‐oxidant–antioxidant balance (PAB) were measured. Blood samples were obtained in the morning prior to initiation of study and the morning after expiration of the bleaching period. The collected data were analyzed using Student's t‐test with 95% confidence interval.
Results
Twenty‐three subjects completed the study. MDA, PAB and TAC were significantly increased after the bleaching period (P = 0.001, 0.001 and 0.002, respectively).
Conclusions
At‐home bleaching revealed the potential to disturb oxidant–antioxidant balance and induce oxidative stress. Its clinical relevance is unfavourable and potential side‐effects of at‐home bleaching should be considered. |
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| AbstractList | At-home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth-whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at-home bleaching on serum redox homeostasis.
Twenty-nine healthy volunteers who requested tooth-whitening participated in this study. Specified bleaching trays were fabricated for the maxilla and mandible arches. Each participant was given two syringes containing 9% hydrogen peroxide gel to use for 30 min/night for 14 nights consecutively. To evaluate the redox status, the serum concentrations of malondialdehyde (MDA), total antioxidant capacity (TAC) and pro-oxidant-antioxidant balance (PAB) were measured. Blood samples were obtained in the morning prior to initiation of study and the morning after expiration of the bleaching period. The collected data were analyzed using Student's t-test with 95% confidence interval.
Twenty-three subjects completed the study. MDA, PAB and TAC were significantly increased after the bleaching period (P = 0.001, 0.001 and 0.002, respectively).
At-home bleaching revealed the potential to disturb oxidant-antioxidant balance and induce oxidative stress. Its clinical relevance is unfavourable and potential side-effects of at-home bleaching should be considered. At-home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth-whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at-home bleaching on serum redox homeostasis.BACKGROUNDAt-home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth-whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at-home bleaching on serum redox homeostasis.Twenty-nine healthy volunteers who requested tooth-whitening participated in this study. Specified bleaching trays were fabricated for the maxilla and mandible arches. Each participant was given two syringes containing 9% hydrogen peroxide gel to use for 30 min/night for 14 nights consecutively. To evaluate the redox status, the serum concentrations of malondialdehyde (MDA), total antioxidant capacity (TAC) and pro-oxidant-antioxidant balance (PAB) were measured. Blood samples were obtained in the morning prior to initiation of study and the morning after expiration of the bleaching period. The collected data were analyzed using Student's t-test with 95% confidence interval.METHODSTwenty-nine healthy volunteers who requested tooth-whitening participated in this study. Specified bleaching trays were fabricated for the maxilla and mandible arches. Each participant was given two syringes containing 9% hydrogen peroxide gel to use for 30 min/night for 14 nights consecutively. To evaluate the redox status, the serum concentrations of malondialdehyde (MDA), total antioxidant capacity (TAC) and pro-oxidant-antioxidant balance (PAB) were measured. Blood samples were obtained in the morning prior to initiation of study and the morning after expiration of the bleaching period. The collected data were analyzed using Student's t-test with 95% confidence interval.Twenty-three subjects completed the study. MDA, PAB and TAC were significantly increased after the bleaching period (P = 0.001, 0.001 and 0.002, respectively).RESULTSTwenty-three subjects completed the study. MDA, PAB and TAC were significantly increased after the bleaching period (P = 0.001, 0.001 and 0.002, respectively).At-home bleaching revealed the potential to disturb oxidant-antioxidant balance and induce oxidative stress. Its clinical relevance is unfavourable and potential side-effects of at-home bleaching should be considered.CONCLUSIONSAt-home bleaching revealed the potential to disturb oxidant-antioxidant balance and induce oxidative stress. Its clinical relevance is unfavourable and potential side-effects of at-home bleaching should be considered. Background At‐home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth‐whitening agent. However, no data exist regarding systemic safety of this technique. The aim of this study was to investigate the effect of at‐home bleaching on serum redox homeostasis. Methods Twenty‐nine healthy volunteers who requested tooth‐whitening participated in this study. Specified bleaching trays were fabricated for the maxilla and mandible arches. Each participant was given two syringes containing 9% hydrogen peroxide gel to use for 30 min/night for 14 nights consecutively. To evaluate the redox status, the serum concentrations of malondialdehyde (MDA), total antioxidant capacity (TAC) and pro‐oxidant–antioxidant balance (PAB) were measured. Blood samples were obtained in the morning prior to initiation of study and the morning after expiration of the bleaching period. The collected data were analyzed using Student's t‐test with 95% confidence interval. Results Twenty‐three subjects completed the study. MDA, PAB and TAC were significantly increased after the bleaching period (P = 0.001, 0.001 and 0.002, respectively). Conclusions At‐home bleaching revealed the potential to disturb oxidant–antioxidant balance and induce oxidative stress. Its clinical relevance is unfavourable and potential side‐effects of at‐home bleaching should be considered. |
| Author | Farkhondeh, N Mehraban Moghadam, S Nejat, AH Akbari, M Hashemy, SI Mohammadipour, HS |
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| Cites_doi | 10.1542/peds.85.4.593 10.1007/s00784-009-0302-4 10.1016/j.oraloncology.2005.10.020 10.1177/154411130301400406 10.1016/j.metabol.2008.02.016 10.5551/jat.1255 10.1515/CCLM.2003.034 10.14219/jada.archive.1997.0423 10.1042/cs0840407 10.1097/00000433-199403000-00011 10.1111/j.1582-4934.2009.00845.x 10.1016/0891-5849(91)90192-6 10.14219/jada.archive.2002.0332 10.1073/pnas.78.11.6858 10.1309/WTEET9TJ2LUMB3C3 10.1211/jpp.60.9.0017 10.1161/01.STR.25.5.1065 10.14219/jada.archive.1991.0310 10.1016/j.cden.2011.01.003 10.1007/978-1-4615-1833-4_4 10.1016/j.scitotenv.2010.06.058 10.1042/bj3240001 10.1016/j.clinbiochem.2007.12.008 10.1093/clinchem/41.12.1819 10.12968/denu.2009.36.9.537 10.1155/2011/467180 10.4103/0976-9668.82309 10.1016/0891-5849(93)90035-S |
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At‐home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth‐whitening agent. However, no data... At-home bleaching is a technique characterized by the use of carbamide peroxide or hydrogen peroxide as a tooth-whitening agent. However, no data exist... |
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| SubjectTerms | Adolescent Adult Dental bleaching Drug Combinations Female Healthy Volunteers Humans hydrogen peroxide Hydrogen Peroxide - administration & dosage Hydrogen Peroxide - adverse effects Male Malondialdehyde - blood Middle Aged oxidative stress Oxidative Stress - drug effects Peroxides - administration & dosage Peroxides - adverse effects redox Self Care Tooth Bleaching Agents - administration & dosage Tooth Bleaching Agents - adverse effects Urea - administration & dosage Urea - adverse effects Urea - analogs & derivatives Young Adult |
| Title | Does at‐home bleaching induce systemic oxidative stress in healthy subjects? |
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