Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. In patients, thrombocytopenia is correlated with an adverse outcome of pneumonia. Platelets can modulate the host response to infection in several ways, that is, by facilitating clot formation, production...

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Veröffentlicht in:	Critical care medicine Jg. 43; H. 3; S. e75
Hauptverfasser:	van den Boogaard, Florry E, Schouten, Marcel, de Stoppelaar, Sacha F, Roelofs, Joris J T H, Brands, Xanthe, Schultz, Marcus J, van't Veer, Cornelis, van der Poll, Tom
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.03.2015
Schlagworte:	Animals Antithrombin III - metabolism Cytokines - metabolism Disease Models, Animal Mice Peptide Hydrolases - metabolism Pneumonia, Pneumococcal - epidemiology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - pathology Purinergic P2Y Receptor Antagonists - pharmacology Streptococcus pneumoniae Thrombocytopenia - epidemiology Thrombocytopenia - immunology Thrombocytopenia - pathology Ticlopidine - analogs & derivatives Ticlopidine - pharmacology
ISSN:	1530-0293, 1530-0293
Online-Zugang:	Weitere Angaben
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