Thrombocytopenia impairs host defense during murine Streptococcus pneumoniae pneumonia

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. In patients, thrombocytopenia is correlated with an adverse outcome of pneumonia. Platelets can modulate the host response to infection in several ways, that is, by facilitating clot formation, production...

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Vydáno v:	Critical care medicine Ročník 43; číslo 3; s. e75
Hlavní autoři:	van den Boogaard, Florry E, Schouten, Marcel, de Stoppelaar, Sacha F, Roelofs, Joris J T H, Brands, Xanthe, Schultz, Marcus J, van't Veer, Cornelis, van der Poll, Tom
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.03.2015
Témata:	Animals Antithrombin III - metabolism Cytokines - metabolism Disease Models, Animal Mice Peptide Hydrolases - metabolism Pneumonia, Pneumococcal - epidemiology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - pathology Purinergic P2Y Receptor Antagonists - pharmacology Streptococcus pneumoniae Thrombocytopenia - epidemiology Thrombocytopenia - immunology Thrombocytopenia - pathology Ticlopidine - analogs & derivatives Ticlopidine - pharmacology
ISSN:	1530-0293, 1530-0293
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