Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA‐296‐5p/CXCL10 axis

Cancer metastasis is a major cause of death among women afflicted with breast cancer (BC) and understanding the molecular processes involved is a major focus in BC research. Circular RNAs (circRNAs) have emerged as genomic regulatory molecules in carcinogenesis and metastasis; however, their role in...

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Veröffentlicht in:	The FEBS journal Jg. 288; H. 3; S. 861 - 883
Hauptverfasser:	Cai, Fenglin, Fu, Wenjie, Tang, Lei, Tang, Jinhai, Sun, Jinming, Fu, Guangshun, Ye, Gang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Blackwell Publishing Ltd 01.02.2021
Schlagworte:	angiogenesis Animals Breast cancer breast neoplasms Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis Carcinogens Cell cycle Cell Line Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Chemokine CXCL10 - genetics Chemokine CXCL10 - metabolism Circular RNA CXCL10 CXCL10 protein death Female Gene Expression Regulation, Neoplastic genomics hsa_circ_0000515 Humans Inflammation Inflammatory response Invasiveness Kaplan-Meier Estimate MCF-7 Cells Metastases Metastasis Mice Mice, Nude MicroRNAs - genetics microRNA‐296‐5p miRNA Prognosis Reporter gene reporter genes Ribonucleic acid RNA RNA Interference RNA, Circular - genetics Xenograft Model Antitumor Assays - methods CXCL10 breast cancer microRNA-296-5p angiogenesis hsa_circ_0000515
ISSN:	1742-464X, 1742-4658, 1742-4658
Online-Zugang:	Volltext
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