Distinct features of multivesicular body‐lysosome fusion revealed by a new cell‐free content‐mixing assay

When marked for degradation, surface receptor and transporter proteins are internalized and delivered to endosomes where they are packaged into intralumenal vesicles (ILVs). Many rounds of ILV formation create multivesicular bodies (MVBs) that fuse with lysosomes exposing ILVs to hydrolases for cata...

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Veröffentlicht in:	Traffic (Copenhagen, Denmark) Jg. 19; H. 2; S. 138 - 149
Hauptverfasser:	Karim, Mahmoud Abdul, Samyn, Dieter Ronny, Mattie, Sevan, Brett, Christopher Leonard
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Former Munksgaard John Wiley & Sons A/S 01.02.2018 Wiley Subscription Services, Inc
Schlagworte:	Biological Transport - physiology Cell fusion Cell-Free System endocytosis Endocytosis - physiology Endosomes Endosomes - metabolism ESCRT Fusion protein lysosome Lysosomes Lysosomes - metabolism membrane fusion Membrane Fusion - physiology Multivesicular Bodies - metabolism multivesicular body Mutation MVB Pep12 Protein Transport Proteins Rab conversion rab GTP-Binding Proteins - metabolism Rab-GTPase Rab7 Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism SNAP receptors SNARE syntaxin vacuole Vesicular Transport Proteins - metabolism Ypt7 Rab7 ESCRT vacuole Rab-GTPase Pep12 SNARE membrane fusion Ypt7 Rab conversion syntaxin multivesicular body MVB endocytosis lysosome
ISSN:	1398-9219, 1600-0854, 1600-0854
Online-Zugang:	Volltext
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