Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization

Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from observational studies, however, is subject to residual confounding, reverse causation, and bias. The primary objective of this study was to evaluate the...

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Vydané v:	Circulation (New York, N.Y.) Ročník 135; číslo 8; s. 741
Hlavní autori:	Chatterjee, Neal A, Giulianini, Franco, Geelhoed, Bastiaan, Lunetta, Kathryn L, Misialek, Jeffrey R, Niemeijer, Maartje N, Rienstra, Michiel, Rose, Lynda M, Smith, Albert V, Arking, Dan E, Ellinor, Patrick T, Heeringa, Jan, Lin, Honghuang, Lubitz, Steven A, Soliman, Elsayed Z, Verweij, Niek, Alonso, Alvaro, Benjamin, Emelia J, Gudnason, Vilmundur, Stricker, Bruno H C, Van Der Harst, Pim, Chasman, Daniel I, Albert, Christine M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 21.02.2017
Predmet:	Aged Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Atrial Fibrillation - epidemiology Atrial Fibrillation - etiology Body Mass Index Cohort Studies Female Genotype Humans Incidence Male Middle Aged Obesity - genetics Obesity - pathology Polymorphism, Single Nucleotide Proportional Hazards Models Prospective Studies Random Allocation Risk Factors epidemiology atrial fibrillation genetics prevention & control obesity
ISSN:	1524-4539, 1524-4539
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