MicroRNAs: history, biogenesis, and their evolving role in animal development and disease

The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries in small RNA biology have redefined the biological landscape by significantly altering the longstanding dogmas that defined gene regulation. These small RNAs play a significant role in modulation of an array of phys...

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Bibliographic Details
Published in:Veterinary pathology Vol. 51; no. 4; p. 759
Main Authors: Bhaskaran, M, Mohan, M
Format: Journal Article
Language:English
Published: United States 01.07.2014
Subjects:
Animal Diseases - genetics
Animal Diseases - metabolism
Animals
Biomarkers - metabolism
Growth and Development - genetics
Growth and Development - physiology
History, 20th Century
History, 21st Century
MicroRNAs - biosynthesis
MicroRNAs - history
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Models, Biological
circulating miRNA
apoptomiR
oncomiR
biomarkers
miR
animal microRNA
ISSN:1544-2217, 1544-2217
Online Access:Get more information
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Summary:The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries in small RNA biology have redefined the biological landscape by significantly altering the longstanding dogmas that defined gene regulation. These small RNAs play a significant role in modulation of an array of physiological and pathological processes ranging from embryonic development to neoplastic progression. Unique miRNA signatures of various inherited, metabolic, infectious, and neoplastic diseases have added a new dimension to the studies that look at their pathogenesis and highlight their potential to be reliable biomarkers. Also, altering miRNA functionality and the development of novel in vivo delivery systems to achieve targeted modulation of specific miRNA function are being actively pursued as novel approaches for therapeutic intervention in many diseases. Here we review the current body of knowledge on the role of miRNAs in development and disease and discuss future implications.
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ISSN:1544-2217
1544-2217
DOI:10.1177/0300985813502820