CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 115; H. 23; S. 5986
Hauptverfasser:	Narasimamurthy, Rajesh, Hunt, Sabrina R, Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L, Forger, Daniel B, Kim, Jae Kyoung, Virshup, David M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.06.2018
Schlagworte:	Animals Casein Kinase Idelta - metabolism Casein Kinase Iepsilon - metabolism Circadian Rhythm - physiology HEK293 Cells Humans Mice Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Phosphorylation cell regulation circadian rhythms protein kinase
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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