Complete mitochondrial genome sequence of the Tyrolean Iceman
The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of...
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| Vydáno v: | Current biology Ročník 18; číslo 21; s. 1687 |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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England
11.11.2008
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| ISSN: | 0960-9822 |
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| Abstract | The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle. |
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| AbstractList | The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle.The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle. The Tyrolean Iceman was a witness to the Neolithic-Copper Age transition in Central Europe 5350-5100 years ago, and his mummified corpse was recovered from an Alpine glacier on the Austro-Italian border in 1991 [1]. Using a mixed sequencing procedure based on PCR amplification and 454 sequencing of pooled amplification products, we have retrieved the first complete mitochondrial-genome sequence of a prehistoric European. We have then compared it with 115 related extant lineages from mitochondrial haplogroup K. We found that the Iceman belonged to a branch of mitochondrial haplogroup K1 that has not yet been identified in modern European populations. This is the oldest complete Homo sapiens mtDNA genome generated to date. The results point to the potential significance of complete-ancient-mtDNA studies in addressing questions concerning the genetic history of human populations that the phylogeography of modern lineages is unable to tackle. |
| Author | Corti, Giorgio Luciani, Stefania Rizzi, Ermanno Olivieri, Cristina Ermini, Luca Soares, Pedro Bonnal, Raoul De Bellis, Gianluca Marota, Isolina Richards, Martin B Rollo, Franco |
| Author_xml | – sequence: 1 givenname: Luca surname: Ermini fullname: Ermini, Luca organization: Laboratorio di Archeo-Antropologia Molecolare/DNA Antico, Dipartimento di Biologia Molecolare, Cellulare e Animale, University of Camerino, 62032 Camerino, Italy – sequence: 2 givenname: Cristina surname: Olivieri fullname: Olivieri, Cristina – sequence: 3 givenname: Ermanno surname: Rizzi fullname: Rizzi, Ermanno – sequence: 4 givenname: Giorgio surname: Corti fullname: Corti, Giorgio – sequence: 5 givenname: Raoul surname: Bonnal fullname: Bonnal, Raoul – sequence: 6 givenname: Pedro surname: Soares fullname: Soares, Pedro – sequence: 7 givenname: Stefania surname: Luciani fullname: Luciani, Stefania – sequence: 8 givenname: Isolina surname: Marota fullname: Marota, Isolina – sequence: 9 givenname: Gianluca surname: De Bellis fullname: De Bellis, Gianluca – sequence: 10 givenname: Martin B surname: Richards fullname: Richards, Martin B – sequence: 11 givenname: Franco surname: Rollo fullname: Rollo, Franco |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18976917$$D View this record in MEDLINE/PubMed |
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| Title | Complete mitochondrial genome sequence of the Tyrolean Iceman |
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