Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling

Protein kinase Cs (PKCs) constitute a family of serine/threonine kinases, which has distinguished and specific roles in regulating cardiac responses, including those associated with heart failure. We found that the PKC θ isoform is expressed at considerable levels in the cardiac muscle in mouse, and...

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Veröffentlicht in:	Cell death & disease Jg. 1; H. 5; S. e45
Hauptverfasser:	Paoletti, R, Maffei, A, Madaro, L, Notte, A, Stanganello, E, Cifelli, G, Carullo, P, Molinaro, M, Lembo, G, Bouché, M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.05.2010 Nature Publishing Group
Schlagworte:	631/443/592 631/45/607/275 692/699/75/74 Animals Antibodies Biochemistry Biomedical and Life Sciences Cardiomegaly - complications Cardiomegaly - diagnostic imaging Cardiomegaly - enzymology Cardiomegaly - physiopathology Cell Biology Cell Count Cell Culture Cell Survival Enzyme Activation Fibroblasts - enzymology Fibroblasts - pathology Gene Deletion Hemodynamics Immunology Isoenzymes - metabolism Life Sciences Mice Mitogen-Activated Protein Kinases - metabolism Myocardium - enzymology Myocardium - pathology Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Original original-article Pressure Protein Kinase C - metabolism Protein Kinase C-theta Ultrasonography Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - enzymology Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling - physiology alpha1-adrenergic agonists protein kinases C cardiomyocyte survival protein kinase C theta dilated cardiomyopathy
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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