Yeast as a model system to study RecQ helicase function

Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1+, respectively. Studies in these yeast species have revealed a plethora of ro...

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Bibliographic Details
Published in:DNA repair Vol. 9; no. 3; pp. 303 - 314
Main Authors: Ashton, Thomas M., Hickson, Ian D.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 02.03.2010
Subjects:
Animals
Bloom's syndrome
DNA Breaks, Double-Stranded
DNA Helicases - metabolism
DNA Repair
DNA, Fungal - metabolism
Homologous recombination
Humans
RecQ Helicases - metabolism
Rqh1
Saccharomyces cerevisiae
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae Proteins - metabolism
Schizosaccharomyces - cytology
Schizosaccharomyces - enzymology
Schizosaccharomyces pombe
Schizosaccharomyces pombe Proteins - metabolism
Sgs1
Bloom's syndrome
Sgs1
Homologous recombination
Rqh1
ISSN:1568-7864, 1568-7856, 1568-7856
Online Access:Get full text
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Summary:Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1+, respectively. Studies in these yeast species have revealed a plethora of roles for the Sgs1 and Rqh1 proteins in repair of double strand breaks, restart of stalled replication forks, processing of aberrant intermediates that arise during meiotic recombination, and maintenance of telomeres. In this review, we focus on the known roles of Sgs1 and Rqh1 and how studies in yeast species have improved our knowledge of how BLM suppresses neoplastic transformation.
Bibliography:ObjectType-Article-1
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ISSN:1568-7864
1568-7856
1568-7856
DOI:10.1016/j.dnarep.2009.12.007