Yeast as a model system to study RecQ helicase function

Mutations in the highly conserved RecQ helicase, BLM, cause the rare cancer predisposition disorder, Bloom's syndrome. The orthologues of BLM in Saccharomyces cerevisiae and Schizosaccharomyces pombe are SGS1 and rqh1+, respectively. Studies in these yeast species have revealed a plethora of ro...

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Bibliographic Details
Published in:	DNA repair Vol. 9; no. 3; pp. 303 - 314
Main Authors:	Ashton, Thomas M., Hickson, Ian D.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 02.03.2010
Subjects:	Animals Bloom's syndrome DNA Breaks, Double-Stranded DNA Helicases - metabolism DNA Repair DNA, Fungal - metabolism Homologous recombination Humans RecQ Helicases - metabolism Rqh1 Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - metabolism Schizosaccharomyces - cytology Schizosaccharomyces - enzymology Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - metabolism Sgs1 Bloom's syndrome Sgs1 Homologous recombination Rqh1
ISSN:	1568-7864, 1568-7856, 1568-7856
Online Access:	Get full text
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