Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression

Insect Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a crucial role in antiviral defense, yet how arboviruses activate this pathway remains unclear. Here, we reveal that outer capsid protein of a double-stranded RNA (dsRNA) arbovirus (rice gall dwarf virus, R...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 44; H. 8; S. 116155
Hauptverfasser:	Chen, Siyu, Tang, Yupeng, Zhang, Chunyu, Li, You, Jia, Dongsheng, Wei, Taiyun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.08.2025 Elsevier
Schlagworte:	Animals antiviral viperin arboviruses CP: Microbiology Dome receptor Hemiptera - metabolism Hemiptera - virology Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - metabolism insect vectors JAK/STAT pathway Janus Kinases - metabolism Phosphorylation Signal Transduction STAT Transcription Factors - metabolism antiviral viperin Dome receptor insect vectors JAK/STAT pathway arboviruses CP: Microbiology
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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