Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma

We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA) using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic analyses prioritized genetic aberrations and revealed hallmarks of iCCA pathogenesis. Aflatoxin signature was associated wit...

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Vydané v:	Cancer cell Ročník 40; číslo 1; s. 70
Hlavní autori:	Dong, Liangqing, Lu, Dayun, Chen, Ran, Lin, Youpei, Zhu, Hongwen, Zhang, Zhou, Cai, Shangli, Cui, Peng, Song, Guohe, Rao, Dongning, Yi, Xinpei, Wu, Yingcheng, Song, Nixue, Liu, Fen, Zou, Yunhao, Zhang, Shu, Zhang, Xiaoming, Wang, Xiaoying, Qiu, Shuangjian, Zhou, Jian, Wang, Shisheng, Zhang, Xu, Shi, Yongyong, Figeys, Daniel, Ding, Li, Wang, Pei, Zhang, Bing, Rodriguez, Henry, Gao, Qiang, Gao, Daming, Zhou, Hu, Fan, Jia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 10.01.2022
Predmet:	Bile Duct Neoplasms - genetics Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Humans Liver - pathology Mutation - genetics Prognosis Proteogenomics - methods Proteomics Tumor Microenvironment - immunology prognostic biomarkers molecular subgroups oncogenic drivers proteogenomics intrahepatic cholangiocarcinoma FGFR2 fusion
ISSN:	1878-3686, 1878-3686
On-line prístup:	Zistit podrobnosti o prístupe
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