Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

Tumor suppressor p53 has inherent propensities to self-associate, which can lead to oncogenic p53 aggregation. The genome caretaker 53BP1 interacts with p53, forms DNA damage-associated condensates, and has been implicated in p53 activation. Modulating the balance between functional p53 self-associa...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 44; H. 8; S. 116090
Hauptverfasser:	Galarreta, Antonio, Pasti, Virginia, Vornberger, Julia, Imhof, Ralph, Oppikofer, Mariano, Altmeyer, Matthias
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 26.08.2025 Elsevier
Schlagworte:	53BP1 Apoptosis biomolecular condensates Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation CNOT1 CP: Cancer CP: Molecular biology Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA damage response genome stability Humans oncogenes p53 p53 aggregation Protein Binding Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor p53-Binding Protein 1 - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism tumor suppressors p53 aggregation genome stability DNA damage response CNOT1 53BP1 CP: Cancer tumor suppressors oncogenes CP: Molecular biology apoptosis p53 biomolecular condensates
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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