Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma

The Polycomb group and oncogene Bmi1 is required for the proliferation of various differentiated cells and for the self-renewal of stem cells and leukemic cancer stem cells. Repression of the Ink4a/Arf locus is a well described mechanism through which Bmi1 can exert its proliferative effects. Howeve...

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Vydáno v:	Cancer cell Ročník 12; číslo 4; s. 328
Hlavní autoři:	Bruggeman, Sophia W M, Hulsman, Danielle, Tanger, Ellen, Buckle, Tessa, Blom, Marleen, Zevenhoven, John, van Tellingen, Olaf, van Lohuizen, Maarten
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.10.2007
Témata:	3T3 Cells Animals Astrocytes - metabolism Astrocytes - pathology Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Differentiation Cell Proliferation Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells, Cultured Cyclin-Dependent Kinase Inhibitor p16 - deficiency Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude Mutation Neoplasm Staging Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neurons - metabolism Neurons - pathology Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype Polycomb Repressive Complex 1 Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Signal Transduction - genetics Stem Cells - metabolism Stem Cells - pathology Time Factors Transduction, Genetic
ISSN:	1535-6108
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