Whole‐brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals

MRI‐based neuroimaging techniques have been used to investigate brain injury associated with HIV‐infection. Whole‐brain cortical mean‐field dynamic modeling provides a way to integrate structural and functional imaging outcomes, allowing investigation of microscale brain dynamics. In this study, we...

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Bibliographic Details
Published in:	Human brain mapping Vol. 42; no. 1; pp. 95 - 109
Main Authors:	Zhuang, Yuchuan, Zhang, Zhengwu, Tivarus, Madalina, Qiu, Xing, Zhong, Jianhui, Schifitto, Giovanni
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.01.2021
Subjects:	Adult Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Brain Brain - diagnostic imaging Brain - pathology Brain - physiopathology Brain injury Clustering Cognitive ability Computational neuroscience Computer simulation Computer-generated environments Connectome Correlation analysis Default Mode Network - diagnostic imaging Default Mode Network - pathology Default Mode Network - physiopathology Diffusion Tensor Imaging Dynamic models Dynamic structural analysis Dynamics Echo-Planar Imaging Female Follow-Up Studies graph theoretical analysis Head injuries Highly active antiretroviral therapy HIV HIV (Viruses) HIV infection HIV Infections - diagnostic imaging HIV Infections - drug therapy HIV Infections - pathology HIV Infections - physiopathology HIV patients Human immunodeficiency virus Humans Infection Injuries Investigations Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical imaging Medical research Medicine, Experimental Models, Theoretical Nerve Net - diagnostic imaging Nerve Net - pathology Nerve Net - physiopathology Neural networks Neuroimaging Neuroimaging - methods Parameters resting‐state functional MRI Structure-function relationships Topology tractography whole‐brain computational modeling tractography HIV-infection whole-brain computational modeling resting-state functional MRI graph theoretical analysis
ISSN:	1065-9471, 1097-0193, 1097-0193
Online Access:	Get full text
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