A new approach for sizing trials with composite binary endpoints using anticipated marginal values and accounting for the correlation between components

Composite binary endpoints are increasingly used as primary endpoints in clinical trials. When designing a trial, it is crucial to determine the appropriate sample size for testing the statistical differences between treatment groups for the primary endpoint. As shown in this work, when using a comp...

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Bibliographic Details
Published in:	Statistics in medicine Vol. 38; no. 11; pp. 1935 - 1956
Main Authors:	Bofill Roig, Marta, Gómez Melis, Guadalupe
Format:	Journal Article Publication
Language:	English
Published:	England Wiley Subscription Services, Inc 20.05.2019
Subjects:	62 Statistics 62D05 Sampling theory, sample surveys 68 Computer science 68U Computing methodologies and applications 92 Biology and other natural sciences 92B Mathematical biology in general Biomatemàtica Biomathematics Classificació AMS Clinical trials composite binary endpoints Computing Methodologies correlated endpoints Estadística aplicada Estadística biosanitària Estadística matemàtica Informàtica Matemàtica aplicada a les ciències Matemàtiques i estadística Mostreig (Estadística) Mètodes estadístics Research methodology Sample size Sampling (Statistics) Àrees temàtiques de la UPC composite binary endpoints correlated endpoints sample size
ISSN:	0277-6715, 1097-0258, 1097-0258
Online Access:	Get full text
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