Asymmetric Hydrogenation of Quinoxalines Catalyzed by Iridium/PipPhos

A catalyst made in situ from the (cyclooctadiene)iridium chloride dimer, [Ir(COD)Cl]2, and the monodentate phosphoramidite ligand (S)‐PipPhos was used in the enantioselective hydrogenation of 2‐ and 2,6‐substituted quinoxalines. In the presence of piperidine hydrochloride as additive full conversion...

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Veröffentlicht in:Advanced synthesis & catalysis Jg. 351; H. 16; S. 2549 - 2552
Hauptverfasser: Mršić, Nataša, Jerphagnon, Thomas, Minnaard, Adriaan J., Feringa, Ben L., de Vries, Johannes G.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim WILEY-VCH Verlag 01.11.2009
WILEY‐VCH Verlag
Wiley
Schlagworte:
asymmetric catalysis
Chemistry
Chemistry, Applied
Chemistry, Organic
heterocycles
homogeneous catalysis
hydrogenation
iridium
phosphoramidites
Physical Sciences
Science & Technology
ANALOGS
IMINES
MONODENTATE PHOSPHORAMIDITES
TETRAHYDROFOLIC ACID
COMPLEXES
RECEPTOR
asymmetric catalysis
hydrogenation
iridium
phosphoramidites
homogeneous catalysis
heterocycles
ENANTIOSELECTIVE HYDROGENATION
LIGAND LIBRARIES
AGENTS
ISSN:1615-4150, 1615-4169
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Beschreibung
Zusammenfassung:A catalyst made in situ from the (cyclooctadiene)iridium chloride dimer, [Ir(COD)Cl]2, and the monodentate phosphoramidite ligand (S)‐PipPhos was used in the enantioselective hydrogenation of 2‐ and 2,6‐substituted quinoxalines. In the presence of piperidine hydrochloride as additive full conversions and enantioselectivities of up to 96% are obtained.
Bibliographie:istex:94B5C9C231AD93658B0A6319E89ED96057DEDEA7
ark:/67375/WNG-1DTDGWJ6-N
ArticleID:ADSC200900522
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900522