Reframing the association and significance of co-morbidities in heart failure

Several co‐existing diseases and/or conditions (co‐morbidities) are present in patients with heart failure (HF), with diverse clinical relevance. Multiple mechanisms may underlie the co‐existence of HF and co‐morbidities, including direct causation, associated risk factors, heterogeneity, and indepe...

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Veröffentlicht in:	European journal of heart failure Jg. 18; H. 7; S. 744 - 758
Hauptverfasser:	Triposkiadis, Filippos, Giamouzis, Gregory, Parissis, John, Starling, Randall C., Boudoulas, Harisios, Skoularigis, John, Butler, Javed, Filippatos, Gerasimos
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Oxford, UK John Wiley & Sons, Ltd 01.07.2016
Schlagworte:	Anaemia Anemia - epidemiology Atrial Fibrillation - epidemiology Atrial fibrillation Causality Comorbidity Coronary artery disease Coronary Artery Disease - epidemiology Depression Depressive Disorder - epidemiology Diabetes Diabetes Mellitus - epidemiology Heart failure Heart Failure - epidemiology Heart Failure - physiopathology Humans Hypertension Hypertension - epidemiology Incidence Kidney disease Myocardial infarction Obesity Obesity - epidemiology Obstructive pulmonary disease Prevalence Pulmonary Disease, Chronic Obstructive - epidemiology Renal failure Renal Insufficiency, Chronic - epidemiology Risk Factors Sleep Apnea Syndromes - epidemiology Sleep-disordered breathing Stroke Volume - physiology Heart failure Hypertension Kidney disease Myocardial infarction Obesity Anaemia Atrial fibrillation Depression Coronary artery disease Sleep-disordered breathing Renal failure Diabetes Obstructive pulmonary disease
ISSN:	1388-9842, 1879-0844
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Abstract	Several co‐existing diseases and/or conditions (co‐morbidities) are present in patients with heart failure (HF), with diverse clinical relevance. Multiple mechanisms may underlie the co‐existence of HF and co‐morbidities, including direct causation, associated risk factors, heterogeneity, and independence. The complex inter‐relationship of co‐morbidities and their impact on the cardiovascular system contribute to the features of HF, both with reduced (HFrEF) and preserved ejection fraction (HFpEF). The purpose of this work is to provide an overview of the contribution of major cardiac and non‐cardiac co‐morbidities to HF development and outcomes, in the context of both HFpEF and HFrEF. Accordingly, epidemiological evidence linking co‐morbidities to HF and the effect of prevalent and incident co‐morbidities on HF outcome will be reviewed.
AbstractList	Several co-existing diseases and/or conditions (co-morbidities) are present in patients with heart failure (HF), with diverse clinical relevance. Multiple mechanisms may underlie the co-existence of HF and co-morbidities, including direct causation, associated risk factors, heterogeneity, and independence. The complex inter-relationship of co-morbidities and their impact on the cardiovascular system contribute to the features of HF, both with reduced (HFrEF) and preserved ejection fraction (HFpEF). The purpose of this work is to provide an overview of the contribution of major cardiac and non-cardiac co-morbidities to HF development and outcomes, in the context of both HFpEF and HFrEF. Accordingly, epidemiological evidence linking co-morbidities to HF and the effect of prevalent and incident co-morbidities on HF outcome will be reviewed. Several co‐existing diseases and/or conditions (co‐morbidities) are present in patients with heart failure ( HF ), with diverse clinical relevance. Multiple mechanisms may underlie the co‐existence of HF and co‐morbidities, including direct causation, associated risk factors, heterogeneity, and independence. The complex inter‐relationship of co‐morbidities and their impact on the cardiovascular system contribute to the features of HF , both with reduced ( HFrEF ) and preserved ejection fraction ( HFpEF ). The purpose of this work is to provide an overview of the contribution of major cardiac and non‐cardiac co‐morbidities to HF development and outcomes, in the context of both HFpEF and HFrEF . Accordingly, epidemiological evidence linking co‐morbidities to HF and the effect of prevalent and incident co‐morbidities on HF outcome will be reviewed.
Author	Skoularigis, John Boudoulas, Harisios Triposkiadis, Filippos Starling, Randall C. Butler, Javed Giamouzis, Gregory Parissis, John Filippatos, Gerasimos
Author_xml	– sequence: 1 givenname: Filippos surname: Triposkiadis fullname: Triposkiadis, Filippos email: ftriposkiadis@gmail.com organization: Department of Cardiology, Larissa University Hospital, Larissa, Greece – sequence: 2 givenname: Gregory surname: Giamouzis fullname: Giamouzis, Gregory organization: Department of Cardiology, Larissa University Hospital, Larissa, Greece – sequence: 3 givenname: John surname: Parissis fullname: Parissis, John organization: Department of Cardiology, Athens University Hospital Attikon, Athens, Greece – sequence: 4 givenname: Randall C. surname: Starling fullname: Starling, Randall C. organization: Kaufman Center for Heart Failure, Cleveland Clinic and the Cleveland Clinic Lerner College of Medicine, OH, Cleveland, USA – sequence: 5 givenname: Harisios surname: Boudoulas fullname: Boudoulas, Harisios organization: The Ohio State University, Columbus, OH, USA; Biomedical Research Foundation Academy of Athens, Athens, and, Aristotelian University of Thessaloniki, Thessaloniki, Greece – sequence: 6 givenname: John surname: Skoularigis fullname: Skoularigis, John organization: Department of Cardiology, Larissa University Hospital, Larissa, Greece – sequence: 7 givenname: Javed surname: Butler fullname: Butler, Javed organization: Cardiology Division, School of Medicine, Stony Brook University, Stony BrookNY, USA – sequence: 8 givenname: Gerasimos surname: Filippatos fullname: Filippatos, Gerasimos organization: Department of Cardiology, Athens University Hospital Attikon, Athens, Greece
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27358242$$D View this record in MEDLINE/PubMed
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PublicationCentury	2000
PublicationDate	July 2016
PublicationDateYYYYMMDD	2016-07-01
PublicationDate_xml	– month: 07 year: 2016 text: July 2016
PublicationDecade	2010
PublicationPlace	Oxford, UK
PublicationPlace_xml	– name: Oxford, UK – name: England
PublicationTitle	European journal of heart failure
PublicationTitleAlternate	Eur J Heart Fail
PublicationYear	2016
Publisher	John Wiley & Sons, Ltd
Publisher_xml	– name: John Wiley & Sons, Ltd
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reference: 27373232 - Eur J Heart Fail. 2016 Jul;18(7):759-61
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Snippet	Several co‐existing diseases and/or conditions (co‐morbidities) are present in patients with heart failure (HF), with diverse clinical relevance. Multiple... Several co‐existing diseases and/or conditions (co‐morbidities) are present in patients with heart failure ( HF ), with diverse clinical relevance. Multiple... Several co-existing diseases and/or conditions (co-morbidities) are present in patients with heart failure (HF), with diverse clinical relevance. Multiple...
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SubjectTerms	Anaemia Anemia - epidemiology Atrial Fibrillation - epidemiology Atrial fibrillation Causality Comorbidity Coronary artery disease Coronary Artery Disease - epidemiology Depression Depressive Disorder - epidemiology Diabetes Diabetes Mellitus - epidemiology Heart failure Heart Failure - epidemiology Heart Failure - physiopathology Humans Hypertension Hypertension - epidemiology Incidence Kidney disease Myocardial infarction Obesity Obesity - epidemiology Obstructive pulmonary disease Prevalence Pulmonary Disease, Chronic Obstructive - epidemiology Renal failure Renal Insufficiency, Chronic - epidemiology Risk Factors Sleep Apnea Syndromes - epidemiology Sleep-disordered breathing Stroke Volume - physiology
Title	Reframing the association and significance of co-morbidities in heart failure
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