The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival

T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients have refractory disease or relapse and die from the disease. To improve patient outcome new therapeutics are needed. With the aim to identify new therapeutic...

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Bibliographic Details

Published in:	Haematologica (Roma) Vol. 109; no. 11; pp. 3505 - 3519
Main Authors:	Stanulović, Vesna S., Al Omair, Shorog, Reed, Michelle A.C., Roberts, Jennie, Potluri, Sandeep, Fulton-Ward, Taylor, Gudgeon, Nancy, Bishop, Emma L., Roels, Juliette, Perry, Tracey A., Sarkar, Sovan, Pratt, Guy, Taghon, Tom, Dimeloe, Sarah, Günther, Ulrich L., Ludwig, Christian, Hoogenkamp, Maarten
Format:	Journal Article
Language:	English
Published:	Italy Fondazione Ferrata Storti 01.11.2024 Ferrata Storti Foundation
Subjects:	Acute Lymphoblastic Leukemia Aspartic Acid - metabolism Cell Line, Tumor Cell Proliferation Cell Survival Excitatory Amino Acid Transporter 1 - genetics Excitatory Amino Acid Transporter 1 - metabolism Glutamine - metabolism Humans Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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