Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry
Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in th...
Uloženo v:
| Vydáno v: | Neuro-oncology (Charlottesville, Va.) Ročník 24; číslo 1; s. 141 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
05.01.2022
|
| Témata: | |
| ISSN: | 1523-5866, 1523-5866 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry (IDIPGR).
Patients ≥10 years of age at diagnosis enrolled in the IDIPGR with imaging confirmed DIPG diagnosis were included. The primary outcome was overall survival (OS) categorized as long-term survivors (LTS) (≥24 months) or short-term survivors (STS) (<24 months).
Among 1010 patients, 208 (21%) were ≥10 years of age at diagnosis; 152 were eligible with a median age of 12 years (range 10-26.8). Median OS was 13 (2-82) months. The 1-, 3-, and 5-year OS was 59.2%, 5.3%, and 3.3%, respectively. The 18/152 (11.8%) LTS were more likely to be older (P < .01) and present with longer symptom duration (P < .01). Biopsy and/or autopsy were performed in 50 (33%) patients; 77%, 61%, 33%, and 6% of patients tested had H3K27M (H3F3A or HIST1H3B), TP53, ATRX, and ACVR1 mutations/genome alterations, respectively. Two of 18 patients with IDH1 testing were IDH1-mutant and 1 was a LTS. The presence or absence of H3 alterations did not affect survival.
Patients ≥10 years old with DIPG have a median survival of 13 months. LTS present with longer symptom duration and are likely to be older at presentation compared to STS. ATRX mutation rates were higher in this population than the general DIPG population. |
|---|---|
| AbstractList | Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry (IDIPGR).BACKGROUNDDiffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry (IDIPGR).Patients ≥10 years of age at diagnosis enrolled in the IDIPGR with imaging confirmed DIPG diagnosis were included. The primary outcome was overall survival (OS) categorized as long-term survivors (LTS) (≥24 months) or short-term survivors (STS) (<24 months).METHODSPatients ≥10 years of age at diagnosis enrolled in the IDIPGR with imaging confirmed DIPG diagnosis were included. The primary outcome was overall survival (OS) categorized as long-term survivors (LTS) (≥24 months) or short-term survivors (STS) (<24 months).Among 1010 patients, 208 (21%) were ≥10 years of age at diagnosis; 152 were eligible with a median age of 12 years (range 10-26.8). Median OS was 13 (2-82) months. The 1-, 3-, and 5-year OS was 59.2%, 5.3%, and 3.3%, respectively. The 18/152 (11.8%) LTS were more likely to be older (P < .01) and present with longer symptom duration (P < .01). Biopsy and/or autopsy were performed in 50 (33%) patients; 77%, 61%, 33%, and 6% of patients tested had H3K27M (H3F3A or HIST1H3B), TP53, ATRX, and ACVR1 mutations/genome alterations, respectively. Two of 18 patients with IDH1 testing were IDH1-mutant and 1 was a LTS. The presence or absence of H3 alterations did not affect survival.RESULTSAmong 1010 patients, 208 (21%) were ≥10 years of age at diagnosis; 152 were eligible with a median age of 12 years (range 10-26.8). Median OS was 13 (2-82) months. The 1-, 3-, and 5-year OS was 59.2%, 5.3%, and 3.3%, respectively. The 18/152 (11.8%) LTS were more likely to be older (P < .01) and present with longer symptom duration (P < .01). Biopsy and/or autopsy were performed in 50 (33%) patients; 77%, 61%, 33%, and 6% of patients tested had H3K27M (H3F3A or HIST1H3B), TP53, ATRX, and ACVR1 mutations/genome alterations, respectively. Two of 18 patients with IDH1 testing were IDH1-mutant and 1 was a LTS. The presence or absence of H3 alterations did not affect survival.Patients ≥10 years old with DIPG have a median survival of 13 months. LTS present with longer symptom duration and are likely to be older at presentation compared to STS. ATRX mutation rates were higher in this population than the general DIPG population.CONCLUSIONPatients ≥10 years old with DIPG have a median survival of 13 months. LTS present with longer symptom duration and are likely to be older at presentation compared to STS. ATRX mutation rates were higher in this population than the general DIPG population. Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled in the International DIPG Registry (IDIPGR). Patients ≥10 years of age at diagnosis enrolled in the IDIPGR with imaging confirmed DIPG diagnosis were included. The primary outcome was overall survival (OS) categorized as long-term survivors (LTS) (≥24 months) or short-term survivors (STS) (<24 months). Among 1010 patients, 208 (21%) were ≥10 years of age at diagnosis; 152 were eligible with a median age of 12 years (range 10-26.8). Median OS was 13 (2-82) months. The 1-, 3-, and 5-year OS was 59.2%, 5.3%, and 3.3%, respectively. The 18/152 (11.8%) LTS were more likely to be older (P < .01) and present with longer symptom duration (P < .01). Biopsy and/or autopsy were performed in 50 (33%) patients; 77%, 61%, 33%, and 6% of patients tested had H3K27M (H3F3A or HIST1H3B), TP53, ATRX, and ACVR1 mutations/genome alterations, respectively. Two of 18 patients with IDH1 testing were IDH1-mutant and 1 was a LTS. The presence or absence of H3 alterations did not affect survival. Patients ≥10 years old with DIPG have a median survival of 13 months. LTS present with longer symptom duration and are likely to be older at presentation compared to STS. ATRX mutation rates were higher in this population than the general DIPG population. |
| Author | Chintagumpala, Murali Samson, Yvan Packer, Roger J Shih, Chie-Schin Black, Katie Hansford, Jordan R Dholaria, Hetal Fouladi, Maryam Dodgshun, Andrew Zhu, Xiaoting Gururangan, Sridharan Wang, Stacie Shiqi Bartels, Ute Wagner, Lars Dexheimer, Phillip J DeWire, Mariko Hawkins, Cynthia Sandler, Eric Garcia Lombardi, Mercedes Minturn, Jane E Hassall, Tim Asher, Anthony Broniscer, Alberto Bandopadhayay, Pratiti Fisher, Paul G Monje, Michelle Tsui, Karen Kieran, Mark W Broxson, Emmett White, Peter Dorris, Kathleen Koschmann, Carl Erker, Craig Gottardo, Nicholas G Parkin, Sarah Hamideh, Dima Lane, Adam Nazarian, Javad Drissi, Rachid Leach, James Bartlett, Allison Larouche, Valerie Chaney, Brooklyn Ziegler, David S Warren, Katherine E Jones, Blaise V Goldman, Stewart Leary, Sarah Gass, David Fuller, Christine Ma, Jie |
| Author_xml | – sequence: 1 givenname: Craig orcidid: 0000-0003-1394-7167 surname: Erker fullname: Erker, Craig organization: Department of Pediatrics, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada – sequence: 2 givenname: Adam orcidid: 0000-0002-5522-8112 surname: Lane fullname: Lane, Adam organization: Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 3 givenname: Brooklyn surname: Chaney fullname: Chaney, Brooklyn organization: Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 4 givenname: Sarah orcidid: 0000-0003-0225-6184 surname: Leary fullname: Leary, Sarah organization: Division of Hematology/Oncology, Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA – sequence: 5 givenname: Jane E orcidid: 0000-0001-9069-8761 surname: Minturn fullname: Minturn, Jane E organization: Division of Oncology, Children's Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, Pennsylvania, USA – sequence: 6 givenname: Ute orcidid: 0000-0003-2112-5251 surname: Bartels fullname: Bartels, Ute organization: Department of Pediatrics, Division of Oncology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada – sequence: 7 givenname: Roger J orcidid: 0000-0001-9413-7531 surname: Packer fullname: Packer, Roger J organization: Department of Neurology, Center for Neuroscience and Behavioral Medicine, Children's National Hospital, Washington, DC, USA – sequence: 8 givenname: Kathleen orcidid: 0000-0003-0753-2176 surname: Dorris fullname: Dorris, Kathleen organization: Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA – sequence: 9 givenname: Nicholas G orcidid: 0000-0002-1082-6776 surname: Gottardo fullname: Gottardo, Nicholas G organization: Brain Tumour Research Programme, Telethon Kids Institute, Nedlands, Western Australia, Australia – sequence: 10 givenname: Katherine E orcidid: 0000-0003-2173-4129 surname: Warren fullname: Warren, Katherine E organization: Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA – sequence: 11 givenname: Alberto orcidid: 0000-0001-9646-0463 surname: Broniscer fullname: Broniscer, Alberto organization: Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA – sequence: 12 givenname: Mark W orcidid: 0000-0003-2184-7692 surname: Kieran fullname: Kieran, Mark W organization: Department of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts, USA – sequence: 13 givenname: Xiaoting surname: Zhu fullname: Zhu, Xiaoting organization: Department of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 14 givenname: Peter orcidid: 0000-0003-0313-033X surname: White fullname: White, Peter organization: Department of Biomedical Informatics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA – sequence: 15 givenname: Phillip J orcidid: 0000-0003-3965-6894 surname: Dexheimer fullname: Dexheimer, Phillip J organization: Department of Biomedical Informatics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio, USA – sequence: 16 givenname: Katie orcidid: 0000-0002-3269-7303 surname: Black fullname: Black, Katie organization: Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 17 givenname: Anthony surname: Asher fullname: Asher, Anthony organization: Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 18 givenname: Mariko orcidid: 0000-0002-8084-2720 surname: DeWire fullname: DeWire, Mariko organization: Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 19 givenname: Jordan R orcidid: 0000-0001-7733-383X surname: Hansford fullname: Hansford, Jordan R organization: Children's Cancer Centre, Royal Children's Hospital Melbourne Cancer, Cell Biology, Murdoch Children's Research Institute Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia – sequence: 20 givenname: Sridharan orcidid: 0000-0003-0311-7127 surname: Gururangan fullname: Gururangan, Sridharan organization: Preston A. Wells Center for Brain Tumor Therapy, UF Health Shands Hospital, Gainesville, Florida, USA – sequence: 21 givenname: Javad orcidid: 0000-0002-1951-9828 surname: Nazarian fullname: Nazarian, Javad organization: Department of Oncology, University Children's Hospital, Zurich, Zurich, Switzerland – sequence: 22 givenname: David S orcidid: 0000-0001-7451-7916 surname: Ziegler fullname: Ziegler, David S organization: School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia – sequence: 23 givenname: Eric orcidid: 0000-0002-0083-9370 surname: Sandler fullname: Sandler, Eric organization: Department of Pediatrics, Wolfson Children's Hospital and Nemours Children's Specialty Care, Jacksonville, Florida, USA – sequence: 24 givenname: Allison surname: Bartlett fullname: Bartlett, Allison organization: Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 25 givenname: Stewart surname: Goldman fullname: Goldman, Stewart organization: Division of Hematology/Oncology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA – sequence: 26 givenname: Chie-Schin surname: Shih fullname: Shih, Chie-Schin organization: Riley Children's Hospital, Indiana University, Indianapolis, Indiana, USA – sequence: 27 givenname: Tim surname: Hassall fullname: Hassall, Tim organization: Lady Cilento Children's Hospital, Brisbane, Queensland, Australia – sequence: 28 givenname: Hetal surname: Dholaria fullname: Dholaria, Hetal organization: Princess Margaret Hospital for Children and The University of Western Australia, Perth, Western Australia, Australia – sequence: 29 givenname: Pratiti surname: Bandopadhayay fullname: Bandopadhayay, Pratiti organization: Department of Pediatric Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA – sequence: 30 givenname: Yvan surname: Samson fullname: Samson, Yvan organization: Départment de Pédiatrie, CHU Sainte-Justine and Université de Montréal, Montreal, Quebec, Canada – sequence: 31 givenname: Michelle surname: Monje fullname: Monje, Michelle organization: Department of Neurology and Neurological Sciences, Stanford University and Lucile Packard Children's Hospital at Stanford, Stanford, California, USA – sequence: 32 givenname: Paul G surname: Fisher fullname: Fisher, Paul G organization: Department of Neurology and Neurological Sciences, Stanford University and Lucile Packard Children's Hospital at Stanford, Stanford, California, USA – sequence: 33 givenname: Andrew surname: Dodgshun fullname: Dodgshun, Andrew organization: Children's Haematology and Oncology Centre, Christchurch Hospital, Christchurch, New Zealand – sequence: 34 givenname: Sarah surname: Parkin fullname: Parkin, Sarah organization: Children's Haematology and Oncology Centre, Christchurch Hospital, Christchurch, New Zealand – sequence: 35 givenname: Murali surname: Chintagumpala fullname: Chintagumpala, Murali organization: Department of Pediatrics, Section of Hematology/Oncology, Texas Children's Cancer Center, Houston, Texas, USA – sequence: 36 givenname: Karen surname: Tsui fullname: Tsui, Karen organization: Starship Children's Hospital, Auckland, New Zealand – sequence: 37 givenname: David surname: Gass fullname: Gass, David organization: Division Hematology and Oncology, Levine Children's Cancer & Blood Disorders, Charlotte, North Carolina, USA – sequence: 38 givenname: Valerie surname: Larouche fullname: Larouche, Valerie organization: Department of Pediatrics, Centre Mère-enfant Soleil du CHU de Québec-Université Laval, Quebec City, Quebec, Canada – sequence: 39 givenname: Emmett surname: Broxson fullname: Broxson, Emmett organization: Division of Hematology/Oncology, Wright State University and Dayton Children's Hospital, Dayton, Ohio, USA – sequence: 40 givenname: Mercedes surname: Garcia Lombardi fullname: Garcia Lombardi, Mercedes organization: Department of Oncology, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina – sequence: 41 givenname: Stacie Shiqi surname: Wang fullname: Wang, Stacie Shiqi organization: Children's Cancer Centre, Royal Children's Hospital Melbourne Cancer, Cell Biology, Murdoch Children's Research Institute Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia – sequence: 42 givenname: Jie surname: Ma fullname: Ma, Jie organization: Department of Pediatric Neurosurgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China – sequence: 43 givenname: Cynthia surname: Hawkins fullname: Hawkins, Cynthia organization: Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children and the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada – sequence: 44 givenname: Dima surname: Hamideh fullname: Hamideh, Dima organization: Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon – sequence: 45 givenname: Lars orcidid: 0000-0003-4717-9960 surname: Wagner fullname: Wagner, Lars organization: Division of Pediatric Hematology/Oncology, Kentucky Children's Hospital, University of Kentucky, Lexington, Kentucky, USA – sequence: 46 givenname: Carl orcidid: 0000-0002-0825-7615 surname: Koschmann fullname: Koschmann, Carl organization: Department of Pediatrics, C.S. Mott Children's Hospital and University of Michigan School of Medicine, Ann Arbor, Michigan, USA – sequence: 47 givenname: Christine orcidid: 0000-0001-7919-7675 surname: Fuller fullname: Fuller, Christine organization: Department of Pathology, Upstate Medical University, Syracuse, New York, USA – sequence: 48 givenname: Rachid orcidid: 0000-0003-0564-0181 surname: Drissi fullname: Drissi, Rachid organization: The Ohio State University College of Medicine, Columbus, Ohio, USA – sequence: 49 givenname: Blaise V orcidid: 0000-0001-9003-4578 surname: Jones fullname: Jones, Blaise V organization: Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 50 givenname: James orcidid: 0000-0002-8602-4737 surname: Leach fullname: Leach, James organization: Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA – sequence: 51 givenname: Maryam orcidid: 0000-0002-5693-035X surname: Fouladi fullname: Fouladi, Maryam organization: Pediatric Neuro-Oncology Program, Nationwide Children's Hospital, Columbus, Ohio, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34114629$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkM1KAzEUhYNUtP5sXUqWbmpzM5PpjDupWguKIroudzJ32shMMiYZpE8gPogv5pNY_AFX53D4OAfOHhtYZ4mxIxCnIIpkbKl3Vo-twxJSscWGoGQyUnmWDf75XbYXwrMQElQGO2w3SQHSTBZD9jZdoUcdyZsQjQ7c1bzDaMjGwD_fP0DwNaH_znFJ_NXEFa9MXfeBuLHRGxuM5p2z0Vjiy8a4Fs84ck-d85HX3rU8rojP7WbDbpqdxYZfzO9n44vbGX-g5WbYrw_Ydo1NoMNf3WdPV5eP0-vRzd1sPj2_GelUpnFEVABUpdRVnUMOYgIiE5VOEGSpdFaUk5JKECjTvChRYaIFFQTJJJ9kqtIo99nJT2_n3UtPIS5aEzQ1DVpyfVhIlQoFSkm1QY9_0b5sqVp03rTo14u_8-QXQFZ2nA |
| CitedBy_id | crossref_primary_10_1016_j_molcel_2023_08_030 crossref_primary_10_1016_j_neo_2023_100896 crossref_primary_10_1097_MPH_0000000000002853 crossref_primary_10_1007_s11910_023_01317_8 crossref_primary_10_1038_s41568_024_00684_9 crossref_primary_10_1007_s00381_023_05841_3 crossref_primary_10_3390_cells11213376 crossref_primary_10_1080_01658107_2024_2402726 crossref_primary_10_3390_cancers16081566 crossref_primary_10_1007_s00381_024_06730_z crossref_primary_10_3390_cancers17132107 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1093/neuonc/noab140 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1523-5866 |
| ExternalDocumentID | 34114629 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .2P .I3 .XZ .ZR 0R~ 123 18M 2WC 36B 4.4 48X 53G 5VS 5WD 70D AABZA AACZT AAJKP AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AAUAY AAVAP ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABNHQ ABNKS ABPQP ABPTD ABQLI ABQNK ABVGC ABWST ABXVV ABZBJ ACGFO ACGFS ACUFI ACUTO ACYHN ADBBV ADEYI ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AEMQT AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFXAL AGINJ AGKEF AGORE AGQXC AGSYK AGUTN AHGBF AHMMS AHXPO AIAGR AIJHB AJBYB AJEEA AJNCP AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX AOIJS APIBT APWMN ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C45 CDBKE CGR CS3 CUY CVF CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBS ECM EE~ EIF EMB EMOBN ENERS F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HYE HZ~ IOX J21 JXSIZ KBUDW KOP KQ8 KSI KSN MHKGH N9A NGC NOMLY NOYVH NPM O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P P6G PAFKI PEELM Q1. Q5Y RD5 ROX RPM RUSNO RW1 RXO SV3 TEORI TJX TR2 W8F WOQ X7H YAYTL YKOAZ YXANX ~91 7X8 |
| ID | FETCH-LOGICAL-c424t-ee911db2cdf8181071060dc3a12b5c69b7beb10a2489ba5a3c0e9e1378765dca2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 18 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000744580500019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1523-5866 |
| IngestDate | Thu Oct 02 08:43:35 EDT 2025 Mon Jul 21 05:38:30 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | International DIPG Registry DIPG outcomes 10 years old |
| Language | English |
| License | The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c424t-ee911db2cdf8181071060dc3a12b5c69b7beb10a2489ba5a3c0e9e1378765dca2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-0564-0181 0000-0003-2184-7692 0000-0001-7919-7675 0000-0002-0083-9370 0000-0003-4717-9960 0000-0003-0753-2176 0000-0003-2173-4129 0000-0002-5522-8112 0000-0001-7733-383X 0000-0002-8084-2720 0000-0003-1394-7167 0000-0002-5693-035X 0000-0003-2112-5251 0000-0001-9646-0463 0000-0002-3269-7303 0000-0002-1082-6776 0000-0001-9069-8761 0000-0003-3965-6894 0000-0001-9413-7531 0000-0003-0313-033X 0000-0002-8602-4737 0000-0002-1951-9828 0000-0003-0311-7127 0000-0001-7451-7916 0000-0003-0225-6184 0000-0001-9003-4578 0000-0002-0825-7615 |
| OpenAccessLink | https://academic.oup.com/neuro-oncology/article-pdf/24/1/141/42074933/noab140.pdf |
| PMID | 34114629 |
| PQID | 2540515525 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2540515525 pubmed_primary_34114629 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-01-05 |
| PublicationDateYYYYMMDD | 2022-01-05 |
| PublicationDate_xml | – month: 01 year: 2022 text: 2022-01-05 day: 05 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Neuro-oncology (Charlottesville, Va.) |
| PublicationTitleAlternate | Neuro Oncol |
| PublicationYear | 2022 |
| SSID | ssj0021561 |
| Score | 2.4378037 |
| Snippet | Diffuse intrinsic pontine gliomas (DIPG) generally occur in young school-age children, although can occur in adolescents and young adults. The purpose of this... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 141 |
| SubjectTerms | Adolescent Adult Astrocytoma Brain Stem Neoplasms - genetics Child Diffuse Intrinsic Pontine Glioma Glioma - genetics Humans Registries Young Adult |
| Title | Characteristics of patients ≥10 years of age with diffuse intrinsic pontine glioma: a report from the International DIPG/DMG Registry |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/34114629 https://www.proquest.com/docview/2540515525 |
| Volume | 24 |
| WOSCitedRecordID | wos000744580500019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LSsNAFB18IW58vx9cwW1oMjN5jBuR1hfYUkSluzIzmZSCTqppBb9A_BB_zC_xThoVF4LgJotAIExuzj25J3MOIQdIArSUOvZixQM3utFeIjLupYwLlinDeGm7eHsZt1pJpyPa1cCtqH6r_MTEEqjTXLsZeY06auH8wsKjwYPnUqOculpFaEySaYZUxlV13PlSEbCbVX6plHlhEkVfpo2sZs0ot7pmc6kC7v9OL8s2c7rw3xtcJPMVwYTjcUUskQljl8lss5LQV8hL_adFM-QZVOaqBby_vgU-PGP1l-cRa8ANasHFqIwKA307fOxbfLAwyF3EhIHeXT-_l4cgYaw-gNuvAsgq4cesERoX7bNao3kGV6ZXBsytkpvTk-v6uVelMXiaUz70jEFcTBXVaYZNPnDUJPJTzWRAVagjoWKFuO9LyhOhZCiZ9o0wAUNEiMJUS7pGpmxuzQaBROOHZhYpityLyzQTQSqEk3hlJjiXbJPsfy5xF6vdSRjSmnxUdL8XeZOsj59TdzC25ehiP0bYp2LrD1dvkznq9jG4WUq4Q6YzfNfNLpnRT8N-8bhXlhEeW-3mB-JK1Ro |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Characteristics+of+patients+%E2%89%A510+years+of+age+with+diffuse+intrinsic+pontine+glioma%3A+a+report+from+the+International+DIPG%2FDMG+Registry&rft.jtitle=Neuro-oncology+%28Charlottesville%2C+Va.%29&rft.au=Erker%2C+Craig&rft.au=Lane%2C+Adam&rft.au=Chaney%2C+Brooklyn&rft.au=Leary%2C+Sarah&rft.date=2022-01-05&rft.issn=1523-5866&rft.eissn=1523-5866&rft.volume=24&rft.issue=1&rft.spage=141&rft_id=info:doi/10.1093%2Fneuonc%2Fnoab140&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1523-5866&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1523-5866&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1523-5866&client=summon |