Southern African scorpion toxins: An overview
In southern Africa there are 130 species of scorpions and only a few species’ venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous...
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| Vydáno v: | Toxicon (Oxford) Ročník 51; číslo 1; s. 1 - 9 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Oxford
Elsevier Ltd
2008
Elsevier Science |
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| ISSN: | 0041-0101, 1879-3150 |
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| Abstract | In southern Africa there are 130 species of scorpions and only a few species’ venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous potential that lies in this field of research. Southern African scorpion toxins include four long-chain Na
+-channel toxins, four short-chain
α-K
+-channel toxins (
α-KTx), three Ca
2+-channel toxins and also an insect-selective peptide active on K
+ and Cl
− channels. Three antimicrobial peptides have also been isolated and characterized. All of these peptides are diverse not only in function and target but also in the species they are isolated from. |
|---|---|
| AbstractList | In southern Africa there are 130 species of scorpions and only a few species' venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous potential that lies in this field of research. Southern African scorpion toxins include four long-chain Na super(+)-channel toxins, four short-chain alpha -K super(+)-channel toxins ( alpha -KTx), three Ca super(2) super(+)-channel toxins and also an insect-selective peptide active on K super(+) and Cl super(-) channels. Three antimicrobial peptides have also been isolated and characterized. All of these peptides are diverse not only in function and target but also in the species they are isolated from. In southern Africa there are 130 species of scorpions and only a few species' venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous potential that lies in this field of research. Southern African scorpion toxins include four long-chain Na(+)-channel toxins, four short-chain alpha-K(+)-channel toxins (alpha-KTx), three Ca(2+)-channel toxins and also an insect-selective peptide active on K(+) and Cl(-) channels. Three antimicrobial peptides have also been isolated and characterized. All of these peptides are diverse not only in function and target but also in the species they are isolated from. In southern Africa there are 130 species of scorpions and only a few species’ venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous potential that lies in this field of research. Southern African scorpion toxins include four long-chain Na +-channel toxins, four short-chain α-K +-channel toxins ( α-KTx), three Ca 2+-channel toxins and also an insect-selective peptide active on K + and Cl − channels. Three antimicrobial peptides have also been isolated and characterized. All of these peptides are diverse not only in function and target but also in the species they are isolated from. In southern Africa there are 130 species of scorpions and only a few species' venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous potential that lies in this field of research. Southern African scorpion toxins include four long-chain Na(+)-channel toxins, four short-chain alpha-K(+)-channel toxins (alpha-KTx), three Ca(2+)-channel toxins and also an insect-selective peptide active on K(+) and Cl(-) channels. Three antimicrobial peptides have also been isolated and characterized. All of these peptides are diverse not only in function and target but also in the species they are isolated from.In southern Africa there are 130 species of scorpions and only a few species' venom have been investigated to date. This review gives an overview of the research done on the venom of southern African scorpions and the toxins and peptides identified up to date. It also aims to highlight the enormous potential that lies in this field of research. Southern African scorpion toxins include four long-chain Na(+)-channel toxins, four short-chain alpha-K(+)-channel toxins (alpha-KTx), three Ca(2+)-channel toxins and also an insect-selective peptide active on K(+) and Cl(-) channels. Three antimicrobial peptides have also been isolated and characterized. All of these peptides are diverse not only in function and target but also in the species they are isolated from. |
| Author | du Plessis, L.H. Elgar, D. du Plessis, J.L. |
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| Keywords | Toxin Ion channels Scorpion Cysteine-free peptides Southern Africa Venom Cysteine Scorpionides Peptides Toxicity Animal origin Ionic channel Review Biological activity Arachnida Aminoacid Arthropoda Invertebrata |
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| Snippet | In southern Africa there are 130 species of scorpions and only a few species’ venom have been investigated to date. This review gives an overview of the... In southern Africa there are 130 species of scorpions and only a few species' venom have been investigated to date. This review gives an overview of the... |
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| SubjectTerms | Africa Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Cysteine-free peptides Ion channels Medical sciences Scorpion Scorpion Venoms - chemistry Scorpions - metabolism Southern Africa Toxicology Toxin Toxins, Biological - chemistry Toxins, Biological - toxicity Venom |
| Title | Southern African scorpion toxins: An overview |
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