Hemostatic agents for bleeding: recombinant-activated factor VII and beyond

A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current statu...

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Bibliographic Details
Published in:Seminars in thrombosis and hemostasis Vol. 41; no. 3; p. 342
Main Authors: Franchini, Massimo, Crestani, Silvia, Frattini, Francesco, Sissa, Cinzia, Bonfanti, Carlo
Format: Journal Article
Language:English
Published: United States 01.04.2015
Subjects:
Administration, Oral
Animals
Anticoagulants - therapeutic use
Blood Coagulation Factors - therapeutic use
Factor VIIa - therapeutic use
Hemorrhage - drug therapy
Hemostasis
Hemostatics - therapeutic use
Humans
Prothrombin - therapeutic use
Recombinant Proteins - therapeutic use
Vitamin K - antagonists & inhibitors
ISSN:1098-9064, 1098-9064
Online Access:Get more information
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Summary:A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current status on the use of recombinant-activated factor VII and prothrombin complex concentrates. The safety and effectiveness of these hemostatic agents in reversal of the anticoagulant effects of vitamin K antagonists will be also explored. In addition, their role in the management of acute bleeding associated with the newer direct oral anticoagulants dabigatran, rivaroxaban, and apixaban will be analyzed in a dedicated section.
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ISSN:1098-9064
1098-9064
DOI:10.1055/s-0034-1381234