Hemostatic agents for bleeding: recombinant-activated factor VII and beyond

A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current statu...

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Vydané v:Seminars in thrombosis and hemostasis Ročník 41; číslo 3; s. 342
Hlavní autori: Franchini, Massimo, Crestani, Silvia, Frattini, Francesco, Sissa, Cinzia, Bonfanti, Carlo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.04.2015
Predmet:
Administration, Oral
Animals
Anticoagulants - therapeutic use
Blood Coagulation Factors - therapeutic use
Factor VIIa - therapeutic use
Hemorrhage - drug therapy
Hemostasis
Hemostatics - therapeutic use
Humans
Prothrombin - therapeutic use
Recombinant Proteins - therapeutic use
Vitamin K - antagonists & inhibitors
ISSN:1098-9064, 1098-9064
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Abstract A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current status on the use of recombinant-activated factor VII and prothrombin complex concentrates. The safety and effectiveness of these hemostatic agents in reversal of the anticoagulant effects of vitamin K antagonists will be also explored. In addition, their role in the management of acute bleeding associated with the newer direct oral anticoagulants dabigatran, rivaroxaban, and apixaban will be analyzed in a dedicated section.
AbstractList A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current status on the use of recombinant-activated factor VII and prothrombin complex concentrates. The safety and effectiveness of these hemostatic agents in reversal of the anticoagulant effects of vitamin K antagonists will be also explored. In addition, their role in the management of acute bleeding associated with the newer direct oral anticoagulants dabigatran, rivaroxaban, and apixaban will be analyzed in a dedicated section.A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current status on the use of recombinant-activated factor VII and prothrombin complex concentrates. The safety and effectiveness of these hemostatic agents in reversal of the anticoagulant effects of vitamin K antagonists will be also explored. In addition, their role in the management of acute bleeding associated with the newer direct oral anticoagulants dabigatran, rivaroxaban, and apixaban will be analyzed in a dedicated section.
A rapid restoration of hemostasis should be regarded as a primary goal for management of critical bleeding, which often represents a life-threatening condition. Among the various therapeutic strategies available in this clinical setting, we aim to summarize in this narrative review the current status on the use of recombinant-activated factor VII and prothrombin complex concentrates. The safety and effectiveness of these hemostatic agents in reversal of the anticoagulant effects of vitamin K antagonists will be also explored. In addition, their role in the management of acute bleeding associated with the newer direct oral anticoagulants dabigatran, rivaroxaban, and apixaban will be analyzed in a dedicated section.
Author Franchini, Massimo
Sissa, Cinzia
Bonfanti, Carlo
Crestani, Silvia
Frattini, Francesco
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SubjectTerms Administration, Oral
Animals
Anticoagulants - therapeutic use
Blood Coagulation Factors - therapeutic use
Factor VIIa - therapeutic use
Hemorrhage - drug therapy
Hemostasis
Hemostatics - therapeutic use
Humans
Prothrombin - therapeutic use
Recombinant Proteins - therapeutic use
Vitamin K - antagonists & inhibitors
Title Hemostatic agents for bleeding: recombinant-activated factor VII and beyond
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