Induction chemotherapy and concurrent chemoradiotherapy with cisplatin for T4 nasoethmoidal squamous cell carcinoma: The value of paclitaxel, carboplatin and cetuximab (PCE)

•The optimal therapy for locally advanced sinonasal SCC is still undetermined.•Induction chemotherapy in non-surgically-treated T4 sinonasal SCC was assessed.•IC-PCE yielded an ORR of 80% with a favorable safety profile (Gr3 AEs: 20%).•Adding IC-PCE before chemoradiotherapy provided excellent progno...

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Bibliographic Details
Published in:	Oral oncology Vol. 163; p. 107235
Main Authors:	Tanaka, Nobukazu, Enokida, Tomohiro, Okano, Susumu, Fujisawa, Takao, Tanaka, Hideki, Onaga, Ryutaro, Hoshi, Yuta, Kishida, Takuma, Wada, Akihisa, Sato, Masanobu, Takeshita, Naohiro, Fujisawa, Takeshi, Motegi, Atsushi, Zenda, Sadamoto, Akimoto, Tetsuo, Tahara, Makoto
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2025
Subjects:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carboplatin - administration & dosage Carboplatin - pharmacology Carboplatin - therapeutic use Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cetuximab - administration & dosage Cetuximab - pharmacology Cetuximab - therapeutic use Chemoradiotherapy Chemoradiotherapy - methods Cisplatin - administration & dosage Cisplatin - pharmacology Cisplatin - therapeutic use Female Hematology, Oncology, and Palliative Medicine Humans Induction chemotherapy Induction Chemotherapy - methods Intensity modulated radiotherapy Male Middle Aged Nose Neoplasms - pathology Nose Neoplasms - therapy Otolaryngology Paclitaxel - administration & dosage Paclitaxel - pharmacology Paclitaxel - therapeutic use PCE Proton beam therapy Retrospective Studies Sinonasal malignancy Squamous cell carcinoma Squamous cell carcinoma Induction chemotherapy Intensity modulated radiotherapy PCE Sinonasal malignancy Chemoradiotherapy Proton beam therapy
ISSN:	1368-8375, 1879-0593, 1879-0593
Online Access:	Get full text
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