Chemotherapy-Induced Changes in Plasma Amino Acids and Lipid Oxidation of Resected Patients with Colorectal Cancer: A Background for Future Studies

Previous studies have documented that FOLFOX and XELOX therapies negatively impact the metabolism of skeletal muscle and extra-muscle districts. This pilot study tested whether three-month FOLFOX or XELOX therapy produced changes in plasma amino acid levels (PAAL) (an estimation of whole-body amino...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 10; p. 5300
Main Authors:	Aquilani, Roberto, Brugnatelli, Silvia, Maestri, Roberto, Iadarola, Paolo, Corallo, Salvatore, Pagani, Anna, Serra, Francesco, Bellini, Anna, Buonocore, Daniela, Dossena, Maurizia, Boschi, Federica, Verri, Manuela
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.05.2024
Subjects:	Adjuvant treatment Adult Aged Amino acids Amino Acids - blood Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Cancer patients Cancer therapies Capecitabine - therapeutic use Chemotherapy Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - surgery Creatinine Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drugs Ethnicity Female Females Fluorouracil - therapeutic use Gender differences Humans Leucovorin - therapeutic use Lipid Metabolism - drug effects Lipid Peroxidation - drug effects Lipids Male Malondialdehyde - blood Metabolism Middle Aged Oncology, Experimental Organoplatinum Compounds - therapeutic use Oxaloacetates Oxidation Oxidation-Reduction Oxidative stress Pilot Projects Plasma Protein synthesis Proteins Ratios Toxicity plasma malondialdehyde changes primary tumor location colorectal cancer FOLFOX and XELOX therapy plasma amino acid changes potential clinical implications
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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