Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community
Midlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this association. To investigate associations between adipokines and brain MRI markers in middle-aged adults from the Third-Generation cohort of the Fra...
Uloženo v:
| Vydáno v: | Journal of Alzheimer's disease Ročník 102; číslo 2; s. 449 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.11.2024
|
| Témata: | |
| ISSN: | 1875-8908, 1875-8908 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Midlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this association.
To investigate associations between adipokines and brain MRI markers in middle-aged adults from the Third-Generation cohort of the Framingham Heart Study.
Serum adiponectin, retinol-binding protein 4 (RBP4), fetuin-A, and Fatty Acid-Binding Protein 4 (FABP4) concentrations were measured by enzymatic immunoassays. MRI measures included total brain, cortical gray matter, hippocampal (total and anterior), lateral ventricular, and white matter hyperintensity volumes. We used linear regression models to separately relate adipokine concentrations to MRI measures, adjusting for potential confounders.
We included 1882 participants (mean age of 48 ± 8 years, 54% women). Higher RBP4 concentrations were related to markers of brain atrophy, including smaller total (Beta ± standard error, -0.05 ± 0.02; p = 0.014) and cortical gray brain volumes (-0.06 ± 0.02; p = 0.004), and larger lateral ventricular volumes (0.06 ± 0.02; p = 0.006). Additionally, higher RBP4 (-0.06 ± 0.03; p = 0.042), Fetuin-A (-0.06 ± 0.03; p = 0.039), and FABP4 (-0.09 ± 0.03; p = 0.008) concentrations were associated with smaller anterior hippocampal volumes. Most associations remained after additional adjustment for vascular risk factors. In exploratory analyses, higher FABP4 was related to larger total brain in non-obese participants, and to smaller anterior hippocampal volumes in obese participants. Finally, higher adiponectin concentrations were related to smaller cortical gray, only in non-obese participants.
Our results suggest that adipokines are associated with markers of brain atrophy during midlife. Further studies are needed to replicate these findings and elucidate any potential mechanisms contributing to abnormal brain aging. |
|---|---|
| AbstractList | Midlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this association.
To investigate associations between adipokines and brain MRI markers in middle-aged adults from the Third-Generation cohort of the Framingham Heart Study.
Serum adiponectin, retinol-binding protein 4 (RBP4), fetuin-A, and Fatty Acid-Binding Protein 4 (FABP4) concentrations were measured by enzymatic immunoassays. MRI measures included total brain, cortical gray matter, hippocampal (total and anterior), lateral ventricular, and white matter hyperintensity volumes. We used linear regression models to separately relate adipokine concentrations to MRI measures, adjusting for potential confounders.
We included 1882 participants (mean age of 48 ± 8 years, 54% women). Higher RBP4 concentrations were related to markers of brain atrophy, including smaller total (Beta ± standard error, -0.05 ± 0.02; p = 0.014) and cortical gray brain volumes (-0.06 ± 0.02; p = 0.004), and larger lateral ventricular volumes (0.06 ± 0.02; p = 0.006). Additionally, higher RBP4 (-0.06 ± 0.03; p = 0.042), Fetuin-A (-0.06 ± 0.03; p = 0.039), and FABP4 (-0.09 ± 0.03; p = 0.008) concentrations were associated with smaller anterior hippocampal volumes. Most associations remained after additional adjustment for vascular risk factors. In exploratory analyses, higher FABP4 was related to larger total brain in non-obese participants, and to smaller anterior hippocampal volumes in obese participants. Finally, higher adiponectin concentrations were related to smaller cortical gray, only in non-obese participants.
Our results suggest that adipokines are associated with markers of brain atrophy during midlife. Further studies are needed to replicate these findings and elucidate any potential mechanisms contributing to abnormal brain aging. Midlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this association.BACKGROUNDMidlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this association.To investigate associations between adipokines and brain MRI markers in middle-aged adults from the Third-Generation cohort of the Framingham Heart Study.OBJECTIVETo investigate associations between adipokines and brain MRI markers in middle-aged adults from the Third-Generation cohort of the Framingham Heart Study.Serum adiponectin, retinol-binding protein 4 (RBP4), fetuin-A, and Fatty Acid-Binding Protein 4 (FABP4) concentrations were measured by enzymatic immunoassays. MRI measures included total brain, cortical gray matter, hippocampal (total and anterior), lateral ventricular, and white matter hyperintensity volumes. We used linear regression models to separately relate adipokine concentrations to MRI measures, adjusting for potential confounders.METHODSSerum adiponectin, retinol-binding protein 4 (RBP4), fetuin-A, and Fatty Acid-Binding Protein 4 (FABP4) concentrations were measured by enzymatic immunoassays. MRI measures included total brain, cortical gray matter, hippocampal (total and anterior), lateral ventricular, and white matter hyperintensity volumes. We used linear regression models to separately relate adipokine concentrations to MRI measures, adjusting for potential confounders.We included 1882 participants (mean age of 48 ± 8 years, 54% women). Higher RBP4 concentrations were related to markers of brain atrophy, including smaller total (Beta ± standard error, -0.05 ± 0.02; p = 0.014) and cortical gray brain volumes (-0.06 ± 0.02; p = 0.004), and larger lateral ventricular volumes (0.06 ± 0.02; p = 0.006). Additionally, higher RBP4 (-0.06 ± 0.03; p = 0.042), Fetuin-A (-0.06 ± 0.03; p = 0.039), and FABP4 (-0.09 ± 0.03; p = 0.008) concentrations were associated with smaller anterior hippocampal volumes. Most associations remained after additional adjustment for vascular risk factors. In exploratory analyses, higher FABP4 was related to larger total brain in non-obese participants, and to smaller anterior hippocampal volumes in obese participants. Finally, higher adiponectin concentrations were related to smaller cortical gray, only in non-obese participants.RESULTSWe included 1882 participants (mean age of 48 ± 8 years, 54% women). Higher RBP4 concentrations were related to markers of brain atrophy, including smaller total (Beta ± standard error, -0.05 ± 0.02; p = 0.014) and cortical gray brain volumes (-0.06 ± 0.02; p = 0.004), and larger lateral ventricular volumes (0.06 ± 0.02; p = 0.006). Additionally, higher RBP4 (-0.06 ± 0.03; p = 0.042), Fetuin-A (-0.06 ± 0.03; p = 0.039), and FABP4 (-0.09 ± 0.03; p = 0.008) concentrations were associated with smaller anterior hippocampal volumes. Most associations remained after additional adjustment for vascular risk factors. In exploratory analyses, higher FABP4 was related to larger total brain in non-obese participants, and to smaller anterior hippocampal volumes in obese participants. Finally, higher adiponectin concentrations were related to smaller cortical gray, only in non-obese participants.Our results suggest that adipokines are associated with markers of brain atrophy during midlife. Further studies are needed to replicate these findings and elucidate any potential mechanisms contributing to abnormal brain aging.CONCLUSIONSOur results suggest that adipokines are associated with markers of brain atrophy during midlife. Further studies are needed to replicate these findings and elucidate any potential mechanisms contributing to abnormal brain aging. |
| Author | Conner, Sarah C Beiser, Alexa S Vasan, Ramachandran S DeCarli, Charles Maillard, Pauline Satizabal, Claudia L Himali, Jayandra Jung Seshadri, Sudha |
| Author_xml | – sequence: 1 givenname: Claudia L orcidid: 0000-0002-1115-4430 surname: Satizabal fullname: Satizabal, Claudia L organization: The Framingham Heart Study, Framingham, MA, USA – sequence: 2 givenname: Jayandra Jung surname: Himali fullname: Himali, Jayandra Jung organization: Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA – sequence: 3 givenname: Sarah C surname: Conner fullname: Conner, Sarah C organization: Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA – sequence: 4 givenname: Alexa S surname: Beiser fullname: Beiser, Alexa S organization: Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA – sequence: 5 givenname: Pauline surname: Maillard fullname: Maillard, Pauline organization: Imaging of Dementia and Aging Laboratory and Center for Neurosciences, Davis, CA, USA – sequence: 6 givenname: Ramachandran S surname: Vasan fullname: Vasan, Ramachandran S organization: Long School of Medicine, UT Health San Antonio, San Antonio, TX, USA – sequence: 7 givenname: Charles surname: DeCarli fullname: DeCarli, Charles organization: Department of Neurology, UC Davis School of Medicine, Sacramento, CA, USA – sequence: 8 givenname: Sudha surname: Seshadri fullname: Seshadri, Sudha organization: Departments of Neurology, Psychiatry, and Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39625328$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkE1LxDAQhoOsuB_6A7xIjl6q-WyaoyyuLqwIoldL0kzXuG26Ju1h_70VV_D0Pi88MzAzR5PQBUDokpIbSpW6pbxQrFCKCcoKTQQ_QTNaKJmNpZj84ymap_RJCOFEqzM05TpnkrNiht6XPlZDY3ofttg4v-92PkDCJjj89LLGrYk7iAl3NbbR-IDN9sccofXONZCZLbhxcGj6hOvYtbj_AFx1bTsE3x_O0WltmgQXx1ygt9X96_Ix2zw_rJd3m6wSTPSZ5GCl0oI5SSuSMwVWCRBS11ozomQtnXVU1YbkhloGeWGd5CJ3RFJSEcsW6Pp37z52XwOkvmx9qqBpTIBuSCWngmgmJeGjenVUB9uCK_fRj0ceyr-fsG9J3WT- |
| CitedBy_id | crossref_primary_10_3390_ijms26020484 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1177/13872877241289043 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 1875-8908 |
| ExternalDocumentID | 39625328 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: R01 AG059727 – fundername: NHLBI NIH HHS grantid: 75N92019D00031 – fundername: NHLBI NIH HHS grantid: HHSN268201500001I – fundername: NINDS NIH HHS grantid: R01 NS017950 – fundername: NINDS NIH HHS grantid: UF1 NS125513 – fundername: NIA NIH HHS grantid: R01 AG066524 – fundername: NIA NIH HHS grantid: R01 AG049607 – fundername: NHLBI NIH HHS grantid: HHSN268201500001C – fundername: NIA NIH HHS grantid: RF1 AG059421 – fundername: NIA NIH HHS grantid: U01 AG058589 |
| GroupedDBID | --- 0R~ 0VX 29J 36B 4.4 53G 5GY AAEJI AAFNC AAFWJ AAGLT AAPII AAQXI AAWTL ABDBF ABIVO ABJNI ABJZC ABUBZ ABUJY ACGFS ACPQW ACPRK ACUHS ADEBD ADZMO AEJQA AELRD AENEX AFRAH AFRHK AFYTF AGIAB AHDMH AIRSE AJGYC AJNRN ALIRC ALMA_UNASSIGNED_HOLDINGS APPIZ ARTOV CAG CGR COF CUY CVF DU5 EAD EAP EBS ECM EIF EJD EMB EMK EMOBN ESX F5P H13 HZ~ IL9 IOS J8X MET MIO MV1 NGNOM NPM O9- P2P Q1R SAUOL SCNPE SFC SV3 TUS VUG 7X8 |
| ID | FETCH-LOGICAL-c424t-53eb57942d51c0627eb74e459f992075f5dbd17fa06a1b2e68bd5346d0510c0b2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001410732700006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1875-8908 |
| IngestDate | Sun Sep 28 06:39:36 EDT 2025 Mon Jul 21 05:56:14 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | epidemiology dementia magnetic resonance imaging adipokines Alzheimer's disease obesity |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c424t-53eb57942d51c0627eb74e459f992075f5dbd17fa06a1b2e68bd5346d0510c0b2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-1115-4430 |
| PMID | 39625328 |
| PQID | 3140925503 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3140925503 pubmed_primary_39625328 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-11-01 |
| PublicationDateYYYYMMDD | 2024-11-01 |
| PublicationDate_xml | – month: 11 year: 2024 text: 2024-11-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of Alzheimer's disease |
| PublicationTitleAlternate | J Alzheimers Dis |
| PublicationYear | 2024 |
| SSID | ssj0003097 |
| Score | 2.4416413 |
| Snippet | Midlife obesity is related to late-onset dementia. Studying adipose tissue-secreted adipokines in the context of brain aging may help us understand this... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 449 |
| SubjectTerms | Adipokines - blood Adiponectin - blood Adult Aging - blood alpha-2-HS-Glycoprotein - analysis alpha-2-HS-Glycoprotein - metabolism Atrophy - pathology Biomarkers - blood Brain - diagnostic imaging Brain - pathology Cohort Studies Fatty Acid-Binding Proteins - blood Female Gray Matter - diagnostic imaging Gray Matter - pathology Humans Magnetic Resonance Imaging Male Middle Aged Retinol-Binding Proteins, Plasma - metabolism |
| Title | Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/39625328 https://www.proquest.com/docview/3140925503 |
| Volume | 102 |
| WOSCitedRecordID | wos001410732700006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JS8NAFB7UevDiglvdGMHrYDJLkjmJFIseWooo9GTJzJuRIia1qYL_3jdJSk-C4CXkEgiPt3xv_Qi5EjYWPpaW-QQUk-A5Q1AvGUZ6oUE7K0Rek02kw2E2HutRW3Cr2rHKpU-sHTWUNtTIr0W4zIT4NxI3sw8WWKNCd7Wl0FgnHYFQJmh1Ol5dCxdRQ66CmJxlOsrarmY4uBSLLMVkIcUAFlptYWnnN4RZR5r-zn__cZdstxiT3jZKsUfWXLFPXnrTua25uopXmsN0Vr6FiXeaF0AHjw_0PczpzCtaemoCbQSt6YsovrzXNQyGjgdofa6jomEphSJ0pLbZL1l8H5Dn_t1T75615ArMSi4XTAlnFBojBxXbcKvYmVQ6qbTXmiOO8AoMxKnPoySPDXdJZkAJmUCwYhsZfkg2irJwx4Q6CyCM8pj5pFIKk0XGOQkQ5zl4hAddcrkU1wSVN3Qk8sKVn9VkJbAuOWpkPpk1VzYmQmNqJnh28oevT8kWR7DR7AiekY5H03XnZNN-LabV_KLWCnwOR4MfpCnBPg |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Circulating+adipokines+and+MRI+markers+of+brain+aging+in+middle-aged+adults+from+the+community&rft.jtitle=Journal+of+Alzheimer%27s+disease&rft.au=Satizabal%2C+Claudia+L&rft.au=Himali%2C+Jayandra+Jung&rft.au=Conner%2C+Sarah+C&rft.au=Beiser%2C+Alexa+S&rft.date=2024-11-01&rft.issn=1875-8908&rft.eissn=1875-8908&rft.volume=102&rft.issue=2&rft.spage=449&rft_id=info:doi/10.1177%2F13872877241289043&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1875-8908&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1875-8908&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1875-8908&client=summon |