Eating disorder and metabolism in narcoleptic patients
To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy. Case controlled pilot study. University hospital. 13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency;...
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| Vydáno v: | Sleep (New York, N.Y.) Ročník 30; číslo 10; s. 1267 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
01.10.2007
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| ISSN: | 0161-8105 |
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| Abstract | To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.
Case controlled pilot study.
University hospital.
13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency; and 6 "atypical" narcoleptics, i.e., HLA negative or without cataplexy), and 9 healthy controls matched for age, gender, and ethnicity.
Energy balance was evaluated by measuring BMI, rest energy expenditure with calorimetry, daily food and water intake, and plasma hormone levels. Eating behavior was evaluated using psychometric tests (EAT-40, EDI2, CIDI-2, MADRS).
Patients with narcolepsy (whether typical or not) tended to be overweight and to have a lower basal metabolism than controls. Only patients with typical narcolepsy tended to eat less than controls. Narcoleptic patients who were overweight ate half as much as others, indicating caloric restriction. Plasma glucose, cortisol, thyroid, and sex hormones levels did not differ between groups, while prolactin levels were twice as high in patients with narcolepsy as in controls. Narcoleptic patients had higher EAT-40 scores and more frequent features of bulimia nervosa (independent of depressive mood) than controls, suggesting a mild eating disorder, classified as "Eating Disorder Not Other Specified."
Both lower basal metabolism and subtle changes in eating behavior (rather than in calorie intake) could explain the positive energy balance leading to overweight in narcolepsy. Eating behavior changes may be a strategy to control weight or to avoid daytime sleepiness. |
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| AbstractList | To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.
Case controlled pilot study.
University hospital.
13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency; and 6 "atypical" narcoleptics, i.e., HLA negative or without cataplexy), and 9 healthy controls matched for age, gender, and ethnicity.
Energy balance was evaluated by measuring BMI, rest energy expenditure with calorimetry, daily food and water intake, and plasma hormone levels. Eating behavior was evaluated using psychometric tests (EAT-40, EDI2, CIDI-2, MADRS).
Patients with narcolepsy (whether typical or not) tended to be overweight and to have a lower basal metabolism than controls. Only patients with typical narcolepsy tended to eat less than controls. Narcoleptic patients who were overweight ate half as much as others, indicating caloric restriction. Plasma glucose, cortisol, thyroid, and sex hormones levels did not differ between groups, while prolactin levels were twice as high in patients with narcolepsy as in controls. Narcoleptic patients had higher EAT-40 scores and more frequent features of bulimia nervosa (independent of depressive mood) than controls, suggesting a mild eating disorder, classified as "Eating Disorder Not Other Specified."
Both lower basal metabolism and subtle changes in eating behavior (rather than in calorie intake) could explain the positive energy balance leading to overweight in narcolepsy. Eating behavior changes may be a strategy to control weight or to avoid daytime sleepiness. To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.STUDY OBJECTIVETo evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.Case controlled pilot study.DESIGNCase controlled pilot study.University hospital.SETTINGSUniversity hospital.13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency; and 6 "atypical" narcoleptics, i.e., HLA negative or without cataplexy), and 9 healthy controls matched for age, gender, and ethnicity.PARTICIPANTS13 patients with narcolepsy (7 "typical" patients, with HLA DQB1*0602 and clear cut cataplexy, with suspected hypocretin deficiency; and 6 "atypical" narcoleptics, i.e., HLA negative or without cataplexy), and 9 healthy controls matched for age, gender, and ethnicity.Energy balance was evaluated by measuring BMI, rest energy expenditure with calorimetry, daily food and water intake, and plasma hormone levels. Eating behavior was evaluated using psychometric tests (EAT-40, EDI2, CIDI-2, MADRS).INTERVENTIONEnergy balance was evaluated by measuring BMI, rest energy expenditure with calorimetry, daily food and water intake, and plasma hormone levels. Eating behavior was evaluated using psychometric tests (EAT-40, EDI2, CIDI-2, MADRS).Patients with narcolepsy (whether typical or not) tended to be overweight and to have a lower basal metabolism than controls. Only patients with typical narcolepsy tended to eat less than controls. Narcoleptic patients who were overweight ate half as much as others, indicating caloric restriction. Plasma glucose, cortisol, thyroid, and sex hormones levels did not differ between groups, while prolactin levels were twice as high in patients with narcolepsy as in controls. Narcoleptic patients had higher EAT-40 scores and more frequent features of bulimia nervosa (independent of depressive mood) than controls, suggesting a mild eating disorder, classified as "Eating Disorder Not Other Specified."RESULTSPatients with narcolepsy (whether typical or not) tended to be overweight and to have a lower basal metabolism than controls. Only patients with typical narcolepsy tended to eat less than controls. Narcoleptic patients who were overweight ate half as much as others, indicating caloric restriction. Plasma glucose, cortisol, thyroid, and sex hormones levels did not differ between groups, while prolactin levels were twice as high in patients with narcolepsy as in controls. Narcoleptic patients had higher EAT-40 scores and more frequent features of bulimia nervosa (independent of depressive mood) than controls, suggesting a mild eating disorder, classified as "Eating Disorder Not Other Specified."Both lower basal metabolism and subtle changes in eating behavior (rather than in calorie intake) could explain the positive energy balance leading to overweight in narcolepsy. Eating behavior changes may be a strategy to control weight or to avoid daytime sleepiness.DISCUSSIONBoth lower basal metabolism and subtle changes in eating behavior (rather than in calorie intake) could explain the positive energy balance leading to overweight in narcolepsy. Eating behavior changes may be a strategy to control weight or to avoid daytime sleepiness. |
| Author | Willer, Jean-Claude Gonzalez, Jesus Arnulf, Isabelle Nasr, Mireille Derenne, Jean-Philippe Foulon, Christine Chabas, Dorothée Lyon-Caen, Olivier |
| Author_xml | – sequence: 1 givenname: Dorothée surname: Chabas fullname: Chabas, Dorothée organization: Fédération des maladies du système nerveux, Programme AVENIR, Inserm U546, France – sequence: 2 givenname: Christine surname: Foulon fullname: Foulon, Christine – sequence: 3 givenname: Jesus surname: Gonzalez fullname: Gonzalez, Jesus – sequence: 4 givenname: Mireille surname: Nasr fullname: Nasr, Mireille – sequence: 5 givenname: Olivier surname: Lyon-Caen fullname: Lyon-Caen, Olivier – sequence: 6 givenname: Jean-Claude surname: Willer fullname: Willer, Jean-Claude – sequence: 7 givenname: Jean-Philippe surname: Derenne fullname: Derenne, Jean-Philippe – sequence: 8 givenname: Isabelle surname: Arnulf fullname: Arnulf, Isabelle |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17969460$$D View this record in MEDLINE/PubMed |
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| Snippet | To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.
Case controlled pilot study.
University hospital.... To evaluate eating behavior and energy balance as a cause of increased body mass index (BMI) in narcolepsy.STUDY OBJECTIVETo evaluate eating behavior and... |
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| SubjectTerms | Adult Blood Glucose - metabolism Body Mass Index Calorimetry Case-Control Studies Energy Intake Energy Metabolism Feeding and Eating Disorders - etiology Feeding and Eating Disorders - metabolism Female Food Preferences Gonadal Steroid Hormones - blood Humans Hydrocortisone - blood Male Narcolepsy - complications Narcolepsy - metabolism Obesity - metabolism Pilot Projects Psychometrics Thyroid Hormones - blood |
| Title | Eating disorder and metabolism in narcoleptic patients |
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