An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery

[Display omitted] ► Development of an integrated diagnosis and therapeutic system for precision malignant gliomas resection. ► Concept proof of the integration of diagnostic and therapeutic techniques. ► 5-Aminolevulinic-acid (5-ALA)-induced fluorescence based intra-operative automatic tumor diagnos...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Medical image analysis Ročník 16; číslo 3; s. 754 - 766
Hlavní autoři: Liao, Hongen, Noguchi, Masafumi, Maruyama, Takashi, Muragaki, Yoshihiro, Kobayashi, Etsuko, Iseki, Hiroshi, Sakuma, Ichiro
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.04.2012
Témata:
5-Aminolevulinic-acid
Amino Acids, Neutral - deficiency
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Equipment Design
Equipment Failure Analysis
Fluorescence
Fluorescent Dyes
Humans
Integrated diagnosis and therapeutic system
Laser Therapy - instrumentation
Medical robotics
Microscopy, Fluorescence - instrumentation
Neurosurgery
Neurosurgical Procedures - instrumentation
Reproducibility of Results
Robotics - instrumentation
Sensitivity and Specificity
Surgery, Computer-Assisted - instrumentation
Systems Integration
Treatment Outcome
Fluorescence
Medical robotics
Neurosurgery
Integrated diagnosis and therapeutic system
5-Aminolevulinic-acid
ISSN:1361-8415, 1361-8423, 1361-8423
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:[Display omitted] ► Development of an integrated diagnosis and therapeutic system for precision malignant gliomas resection. ► Concept proof of the integration of diagnostic and therapeutic techniques. ► 5-Aminolevulinic-acid (5-ALA)-induced fluorescence based intra-operative automatic tumor diagnosis technique. ► High-precision robotic laser ablation therapeutic technique with automatic focusing and robotic scanning mechanism. ► Improved accuracy of the fluorescent measurement of the tumor using high-precision spectral analysis. We have developed an integrated diagnosis and therapeutic system for precision malignant gliomas resection during neurosurgery. A combination of three-dimensional (3-D) magnetic resonance imaging (MRI) navigation and 5-aminolevulinic acid (5-ALA)-induced fluorescence based intra-operative tumor diagnosis technique has been incorporated into a robotic laser ablation neurosurgery system with an automatic focusing and robotic scanning mechanism. 5-ALA is a non-fluorescent prodrug that leads to intracellular accumulation of fluorescent protoporphyrins IX (PpIX) in malignant glioma. The PpIX tends to accumulate in pathological lesions, and emits red fluorescence when excited by blue light. This fluorescence is illuminated with laser excitation, enables intra-operative identification of the position of a tumor and provides guidance for resection with laser photocoagulation. The information provided by the MRI is enhanced by the intra-operative 5-ALA fluorescence data, and this enhanced information is integrated into a robotic laser ablation system. The accuracy of the fluorescent measurement of the tumor is improved using high-precision spectral analysis. The fluorescence assists in the detection of malignant brain tumors intra-operatively and improves their removal rate.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1361-8415
1361-8423
1361-8423
DOI:10.1016/j.media.2010.11.004