Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy

The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the ne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Life (Basel, Switzerland) Jg. 13; H. 12; S. 2254
Hauptverfasser:	Mufti, Afoua, Feriani, Anouar, Contreras, María del Mar, Nehdi, Saber, Hfaeidh, Najla, Tlili, Nizar, Harrath, Abdel Halim
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 25.11.2023
Schlagworte:	acephate Antioxidants Autophagy Bioactive compounds Biomarkers Creatinine DNA fragmentation Drug dosages Ephedra Ephedra alata Exposure Fatty acids Gene expression Genes Immunofluorescence Kidney diseases Kidneys Laboratory animals Lipid peroxidation Lipids Molecular docking Na+/H+-exchanging ATPase Na+/K+-exchanging ATPase nephrotoxicity Offspring Oxidative stress Peroxidation Pesticides Phytochemicals Proteins Risk factors Seeds Sodium Stress analysis Uric acid United States > US Tunisia acephate Ephedra alata autophagy molecular docking nephrotoxicity oxidative stress
ISSN:	2075-1729, 2075-1729
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the nephrotoxicity in adult offspring induced by acephate. In fact, it decreased the levels of creatinine and uric acid and increased the albumin content compared to the intoxicated group. The in utero studies showed that E. alata inhibited the renal oxidative stress generated by acephate exposure by reducing lipid peroxidation and enhancing antioxidant biomarker activities (GSH, CAT, and SOD). The inhibition of DNA fragmentation and the improvement of the ultrastructural changes highlighted the prophylactic effect of E. alata in renal tissue. Additionally, the immunofluorescence study showed the upregulation of LC3 gene expression, suggesting the capacity of E. alata extract to stimulate autophagic processes as a protective mechanism. Molecular docking analysis indicated that hexadecasphinganine, the major compound in E. alata, has a higher affinity toward the Na+/K+-ATPase, epithelial sodium channel (ENaC), and sodium hydrogen exchanger 3 (NHE3) genes than acephate. Hexadecasphinganine could be considered a potential inhibitor of the activity of these genes and therefore exerted its preventive capacity. The obtained findings confirmed that E. alata seed extract exerted nephropreventive capacities, which could be related to its bioactive compounds, which possess antioxidant activities.
AbstractList	The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the nephrotoxicity in adult offspring induced by acephate. In fact, it decreased the levels of creatinine and uric acid and increased the albumin content compared to the intoxicated group. The in utero studies showed that E. alata inhibited the renal oxidative stress generated by acephate exposure by reducing lipid peroxidation and enhancing antioxidant biomarker activities (GSH, CAT, and SOD). The inhibition of DNA fragmentation and the improvement of the ultrastructural changes highlighted the prophylactic effect of E. alata in renal tissue. Additionally, the immunofluorescence study showed the upregulation of LC3 gene expression, suggesting the capacity of E. alata extract to stimulate autophagic processes as a protective mechanism. Molecular docking analysis indicated that hexadecasphinganine, the major compound in E. alata, has a higher affinity toward the Na+/K+-ATPase, epithelial sodium channel (ENaC), and sodium hydrogen exchanger 3 (NHE3) genes than acephate. Hexadecasphinganine could be considered a potential inhibitor of the activity of these genes and therefore exerted its preventive capacity. The obtained findings confirmed that E. alata seed extract exerted nephropreventive capacities, which could be related to its bioactive compounds, which possess antioxidant activities. The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the nephrotoxicity in adult offspring induced by acephate. In fact, it decreased the levels of creatinine and uric acid and increased the albumin content compared to the intoxicated group. The in utero studies showed that E. alata inhibited the renal oxidative stress generated by acephate exposure by reducing lipid peroxidation and enhancing antioxidant biomarker activities (GSH, CAT, and SOD). The inhibition of DNA fragmentation and the improvement of the ultrastructural changes highlighted the prophylactic effect of E. alata in renal tissue. Additionally, the immunofluorescence study showed the upregulation of LC3 gene expression, suggesting the capacity of E. alata extract to stimulate autophagic processes as a protective mechanism. Molecular docking analysis indicated that hexadecasphinganine, the major compound in E. alata, has a higher affinity toward the Na+/K+-ATPase, epithelial sodium channel (ENaC), and sodium hydrogen exchanger 3 (NHE3) genes than acephate. Hexadecasphinganine could be considered a potential inhibitor of the activity of these genes and therefore exerted its preventive capacity. The obtained findings confirmed that E. alata seed extract exerted nephropreventive capacities, which could be related to its bioactive compounds, which possess antioxidant activities.The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that E. alata supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the nephrotoxicity in adult offspring induced by acephate. In fact, it decreased the levels of creatinine and uric acid and increased the albumin content compared to the intoxicated group. The in utero studies showed that E. alata inhibited the renal oxidative stress generated by acephate exposure by reducing lipid peroxidation and enhancing antioxidant biomarker activities (GSH, CAT, and SOD). The inhibition of DNA fragmentation and the improvement of the ultrastructural changes highlighted the prophylactic effect of E. alata in renal tissue. Additionally, the immunofluorescence study showed the upregulation of LC3 gene expression, suggesting the capacity of E. alata extract to stimulate autophagic processes as a protective mechanism. Molecular docking analysis indicated that hexadecasphinganine, the major compound in E. alata, has a higher affinity toward the Na+/K+-ATPase, epithelial sodium channel (ENaC), and sodium hydrogen exchanger 3 (NHE3) genes than acephate. Hexadecasphinganine could be considered a potential inhibitor of the activity of these genes and therefore exerted its preventive capacity. The obtained findings confirmed that E. alata seed extract exerted nephropreventive capacities, which could be related to its bioactive compounds, which possess antioxidant activities. The aim of the current work was to examine for the first time the nephropreventive capacity of seed extract (E) against maternal exposure to acephate in rat offspring. The in vivo results revealed that supplementation for 28 days (40 mg/kg b.w.) significantly attenuated the nephrotoxicity in adult offspring induced by acephate. In fact, it decreased the levels of creatinine and uric acid and increased the albumin content compared to the intoxicated group. The in utero studies showed that inhibited the renal oxidative stress generated by acephate exposure by reducing lipid peroxidation and enhancing antioxidant biomarker activities (GSH, CAT, and SOD). The inhibition of DNA fragmentation and the improvement of the ultrastructural changes highlighted the prophylactic effect of in renal tissue. Additionally, the immunofluorescence study showed the upregulation of gene expression, suggesting the capacity of extract to stimulate autophagic processes as a protective mechanism. Molecular docking analysis indicated that hexadecasphinganine, the major compound in , has a higher affinity toward the Na /K -ATPase, epithelial sodium channel (ENaC), and sodium hydrogen exchanger 3 (NHE3) genes than acephate. Hexadecasphinganine could be considered a potential inhibitor of the activity of these genes and therefore exerted its preventive capacity. The obtained findings confirmed that seed extract exerted nephropreventive capacities, which could be related to its bioactive compounds, which possess antioxidant activities.
Author	Nehdi, Saber Harrath, Abdel Halim Contreras, María del Mar Hfaeidh, Najla Tlili, Nizar Mufti, Afoua Feriani, Anouar
Author_xml	– sequence: 1 givenname: Afoua surname: Mufti fullname: Mufti, Afoua – sequence: 2 givenname: Anouar surname: Feriani fullname: Feriani, Anouar – sequence: 3 givenname: María del Mar orcidid: 0000-0002-3407-0088 surname: Contreras fullname: Contreras, María del Mar – sequence: 4 givenname: Saber surname: Nehdi fullname: Nehdi, Saber – sequence: 5 givenname: Najla surname: Hfaeidh fullname: Hfaeidh, Najla – sequence: 6 givenname: Nizar surname: Tlili fullname: Tlili, Nizar – sequence: 7 givenname: Abdel Halim orcidid: 0000-0002-2170-1303 surname: Harrath fullname: Harrath, Abdel Halim
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38137855$$D View this record in MEDLINE/PubMed
BookMark	eNptkk1v1DAQhiNUREvpjTOyxIUDC_6Ik_i4Wi2wYqUiPs7RxJ6kXmXtxXZQ8x_40XjZUlUVvng088w7M5p5Xpw577AoXjL6TghF34-2RyYY51yWT4oLTmu5YDVXZw_s8-Iqxh3Nr5KsaspnxblomKgbKS-K3-vDDZoABEZIQL4hmkhW3vUYyGdrHM7kS_AJdbLeERjAupjIGsI4k20uTta3Bx-ngCR5stR4uIGEpJvJVxymLGndQK5vrcnWLyQbF6cxEXAms9lzii-n5HPeML8onvYwRry6-y-LHx_W31efFtvrj5vVcrvQJRdp0dPKMMOEQqhqpE3dybLveacllbQWSnKpaK9AQSexgSbDUkvVUd03dc21uCw2J13jYdcegt1DmFsPtv3r8GFoISSrR2wZagSmStrlIrJhjeoMpUJCg9xUqLLWm5PWIfifE8bU7m3UOI7g0E-x5YpKyYWsREZfP0J3fgouT3qkyrqiXNaZenVHTd0ezX17_3aWgbcnQAcfY8D-HmG0PV5F-_AqMs4f4domOK4zBbDj_5P-ABOpumM
CitedBy_id	crossref_primary_10_1016_j_ijbiomac_2025_140877
Cites_doi	10.1016/j.jep.2021.114303 10.1016/j.ijbiomac.2019.11.078 10.1007/s10822-013-9644-8 10.1016/S0076-6879(78)52032-6 10.21203/rs.3.rs-452983/v1 10.1155/2022/5563759 10.1007/s11356-021-15142-4 10.3390/ijms23168855 10.1111/j.1432-1033.1974.tb03714.x 10.1080/00032719.2022.2059082 10.1016/j.biopha.2022.113836 10.1590/2175-8239-jbn-2022-0030en 10.3390/antiox11010015 10.1016/j.ijbiomac.2017.08.096 10.1016/j.aquatox.2022.106204 10.1016/j.heliyon.2022.e11954 10.1016/j.jksus.2023.102575 10.1016/j.kisu.2021.11.003 10.1080/10408398.2023.2203753 10.1016/0003-2697(68)90092-4 10.3390/biology12020162 10.3390/toxics11020135 10.1016/j.tox.2016.10.010 10.1016/j.pestbp.2022.105318 10.3390/ijms23126397 10.1016/j.tox.2018.10.013 10.1021/jm0306430 10.1371/journal.pone.0159034 10.1038/s41401-021-00620-9 10.20944/preprints202306.1277.v1 10.3389/fphar.2022.968226 10.4103/0973-7847.70902 10.7554/eLife.59038 10.3390/nu14142867 10.1038/kisup.2013.79 10.1016/S0076-6879(84)05016-3 10.1016/0003-2697(76)90527-3 10.1016/j.fbio.2023.102657 10.3390/nu14112338 10.1038/nrneph.2017.6 10.1002/tox.23624 10.1101/2020.01.22.909879 10.3390/molecules27072365 10.1007/s11356-020-08937-4 10.1016/j.arabjc.2022.104037 10.1002/tox.23784 10.1007/s11356-021-16091-8 10.1016/j.tox.2020.152636
ContentType	Journal Article
Copyright	2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	AAYXX CITATION NPM 8FD 8FE 8FH ABUWG AEUYN AFKRA ATCPS AZQEC BBNVY BENPR BHPHI CCPQU COVID DWQXO FR3 GNUQQ HCIFZ LK8 M7P P64 PATMY PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS PYCSY RC3 7X8 DOA
DOI	10.3390/life13122254
DatabaseName	CrossRef PubMed Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College Coronavirus Research Database ProQuest Central Korea Engineering Research Database ProQuest Central Student SciTech Collection (ProQuest) ProQuest Biological Science Collection Biological Science Database Biotechnology and BioEngineering Abstracts Environmental Science Database ProQuest One Academic ProQuest One Academic (New) ProQuest - Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Environmental Science Collection Genetics Abstracts MEDLINE - Academic DOAJ: Directory of Open Access Journal (DOAJ)
DatabaseTitle	CrossRef PubMed Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability Genetics Abstracts Natural Science Collection ProQuest Central Korea Agricultural & Environmental Science Collection Biological Science Collection ProQuest Central (New) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Coronavirus Research Database Biological Science Database ProQuest SciTech Collection Biotechnology and BioEngineering Abstracts Environmental Science Collection ProQuest One Academic UKI Edition Environmental Science Database Engineering Research Database ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Publicly Available Content Database PubMed CrossRef
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2075-1729
ExternalDocumentID	oai_doaj_org_article_1ecea1940bb5458189bd0035a8e2d6e9 38137855 10_3390_life13122254
Genre	Journal Article
GeographicLocations	United States--US Tunisia
GeographicLocations_xml	– name: Tunisia – name: United States--US
GrantInformation_xml	– fundername: Researsher Supporting Project grantid: RSP2023R17
GroupedDBID	53G 5VS 7XC 8FE 8FH AADQD AAFWJ AAYXX ABDBF ACUHS ADBBV AEUYN AFFHD AFKRA AFPKN AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS ATCPS BAWUL BBNVY BCNDV BENPR BHPHI CCPQU CITATION DIK ESX GROUPED_DOAJ HCIFZ HYE IAO IEP ISR ITC KQ8 LK8 M48 M7P MODMG M~E OK1 PATMY PGMZT PHGZM PHGZT PIMPY PQGLB PROAC PYCSY RPM NPM 8FD ABUWG AZQEC COVID DWQXO FR3 GNUQQ P64 PKEHL PQEST PQQKQ PQUKI PRINS RC3 7X8 PUEGO
ID	FETCH-LOGICAL-c423t-f06d1d139ea67e087b54ff2bc505073952590f9a9ab5e8a8d1d5c59b0cf8772c3
IEDL.DBID	M7P
ISICitedReferencesCount	1
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001132168600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2075-1729
IngestDate	Fri Oct 03 12:43:31 EDT 2025 Wed Oct 01 14:22:59 EDT 2025 Fri Jul 25 10:47:51 EDT 2025 Wed Feb 19 02:06:23 EST 2025 Sat Nov 29 07:13:34 EST 2025 Tue Nov 18 21:55:14 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Keywords	acephate Ephedra alata autophagy molecular docking nephrotoxicity oxidative stress
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c423t-f06d1d139ea67e087b54ff2bc505073952590f9a9ab5e8a8d1d5c59b0cf8772c3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0002-3407-0088 0000-0002-2170-1303
OpenAccessLink	https://www.proquest.com/docview/2904760257?pq-origsite=%requestingapplication%
PMID	38137855
PQID	2904760257
PQPubID	2032373
ParticipantIDs	doaj_primary_oai_doaj_org_article_1ecea1940bb5458189bd0035a8e2d6e9 proquest_miscellaneous_2905523563 proquest_journals_2904760257 pubmed_primary_38137855 crossref_primary_10_3390_life13122254 crossref_citationtrail_10_3390_life13122254
PublicationCentury	2000
PublicationDate	2023-Nov-25
PublicationDateYYYYMMDD	2023-11-25
PublicationDate_xml	– month: 11 year: 2023 text: 2023-Nov-25 day: 25
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland – name: Basel
PublicationTitle	Life (Basel, Switzerland)
PublicationTitleAlternate	Life (Basel)
PublicationYear	2023
Publisher	MDPI AG
Publisher_xml	– name: MDPI AG
References	Ribeiro (ref_6) 2016; 372 Saidi (ref_38) 2022; 8 Mei (ref_13) 2021; 278 Chen (ref_34) 2022; 13 Liang (ref_12) 2018; 106 Seif (ref_14) 2021; 28 Aebi (ref_19) 1984; 105 ref_52 Onyesife (ref_11) 2023; 19 Kovesdy (ref_1) 2022; 12 Rabelink (ref_53) 2017; 13 (ref_2) 2013; 3 Noreng (ref_25) 2020; 9 Aranha (ref_5) 2021; 447 Lobo (ref_44) 2010; 4 ref_23 ref_22 Adzhigirey (ref_24) 2013; 27 Chinnappan (ref_9) 2019; 2019 Friesner (ref_28) 2004; 47 ref_29 ref_27 ref_26 Li (ref_51) 2022; 249 Sedlak (ref_18) 1968; 25 Yassir (ref_16) 2022; 15 ref_33 Hamdi (ref_46) 2022; 29 ref_32 (ref_10) 2022; 2022 Mahajan (ref_41) 2023; 10 ref_39 Ileriturk (ref_50) 2023; 38 Jain (ref_37) 2023; 85 Ileriturk (ref_35) 2022; 37 Badr (ref_31) 2020; 27 Marklund (ref_20) 1974; 47 Bradford (ref_21) 1976; 72 ref_47 ref_45 ref_43 ref_42 ref_40 Buege (ref_17) 1978; 52 ref_3 Alqahtani (ref_7) 2023; 35 Li (ref_8) 2019; 411 ref_49 ref_48 Fang (ref_30) 2021; 42 ref_4 Mufti (ref_54) 2022; 55 Sule (ref_36) 2022; 2022 Duan (ref_15) 2020; 155
References_xml	– volume: 278 start-page: 114303 year: 2021 ident: ref_13 article-title: Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2021.114303 – volume: 19 start-page: e01453 year: 2023 ident: ref_11 article-title: Nephroprotective effects of Piper nigrum extracts against monosodium glutamate-induced renal toxicity in rats publication-title: Sci. Afr. – volume: 155 start-page: 1114 year: 2020 ident: ref_15 article-title: Preparation, characteristics, and antioxidant activities of carboxymethylated polysaccharides from blackcurrant fruits publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2019.11.078 – volume: 27 start-page: 221 year: 2013 ident: ref_24 article-title: Protein and ligand preparation: Parameters, protocols, and influence on virtual screening enrichments publication-title: J. Comput.-Aided Mol. Des. doi: 10.1007/s10822-013-9644-8 – volume: 52 start-page: 302 year: 1978 ident: ref_17 article-title: Microsomal lipid peroxidation publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(78)52032-6 – ident: ref_3 doi: 10.21203/rs.3.rs-452983/v1 – volume: 2022 start-page: 5563759 year: 2022 ident: ref_36 article-title: A common feature of pesticides: Oxidative stress—The role of oxidative stress in pesticide-induced toxicity publication-title: Oxidative Med. Cell. Longev. doi: 10.1155/2022/5563759 – volume: 28 start-page: 62943 year: 2021 ident: ref_14 article-title: Ephedra sinica mitigates hepatic oxidative stress and inflammation via suppressing the TLR4/MyD88/NF-κB pathway in fipronil-treated rats publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-021-15142-4 – ident: ref_32 doi: 10.3390/ijms23168855 – volume: 47 start-page: 469 year: 1974 ident: ref_20 article-title: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1974.tb03714.x – volume: 55 start-page: 2450 year: 2022 ident: ref_54 article-title: Phytochemical Profiling of Ephedra alata subsp. alenda Seeds by High-Performance Liquid Chromatography—Electrospray Ionization—Quadrupole-Time-of-Flight-Mass Spectrometry (HPLC-ESI-QTOF-MS), Molecular Docking, and Antioxidant, Anti-diabetic, and Acetylcholinesterase Inhibition publication-title: Anal. Lett. doi: 10.1080/00032719.2022.2059082 – ident: ref_47 doi: 10.1016/j.biopha.2022.113836 – ident: ref_4 doi: 10.1590/2175-8239-jbn-2022-0030en – ident: ref_52 doi: 10.3390/antiox11010015 – volume: 106 start-page: 947 year: 2018 ident: ref_12 article-title: Polysaccharide from Ephedra sinica Stapf inhibits inflammation expression by regulating Factor-β1/Smad2 signaling publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2017.08.096 – volume: 249 start-page: 106204 year: 2022 ident: ref_51 article-title: Eucalyptol relieves imidacloprid-induced autophagy through the miR-451/Cab39/AMPK axis in Ctenopharyngodon idellus kidney cells publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2022.106204 – volume: 8 start-page: e11954 year: 2022 ident: ref_38 article-title: Ephedra alata subsp. alenda (Ephedraceae) leaf extracts: Phytochemical screening, anti-diabetic, anti-obesity and anti-toxic activities on diabetic-induced liver-kidney-testes toxicities and inhibition of α-amylase and lipase enzymes publication-title: Heliyon doi: 10.1016/j.heliyon.2022.e11954 – volume: 35 start-page: 102575 year: 2023 ident: ref_7 article-title: Autophagy activation, histopathological damage, and altered renal epithelial sodium channel and Na+, K+-ATPase gene expression in offspring kidney after in utero exposure to allethrin publication-title: J. King Saud. Univ.-Sci. doi: 10.1016/j.jksus.2023.102575 – volume: 12 start-page: 7 year: 2022 ident: ref_1 article-title: Epidemiology of chronic kidney disease: An update 2022 publication-title: Kidney Int. Suppl. doi: 10.1016/j.kisu.2021.11.003 – ident: ref_43 doi: 10.1080/10408398.2023.2203753 – volume: 25 start-page: 192 year: 1968 ident: ref_18 article-title: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent publication-title: Anal. Biochem. doi: 10.1016/0003-2697(68)90092-4 – ident: ref_22 doi: 10.3390/biology12020162 – ident: ref_49 doi: 10.3390/toxics11020135 – volume: 372 start-page: 12 year: 2016 ident: ref_6 article-title: Acephate exposure during a perinatal life program to type 2 diabetes publication-title: Toxicology doi: 10.1016/j.tox.2016.10.010 – ident: ref_45 doi: 10.1016/j.pestbp.2022.105318 – ident: ref_23 doi: 10.3390/ijms23126397 – volume: 411 start-page: 32 year: 2019 ident: ref_8 article-title: Decreased H3K9ac level of AT2R mediates the developmental origin of glomerulosclerosis induced by prenatal dexamethasone exposure in male offspring rats publication-title: Toxicology doi: 10.1016/j.tox.2018.10.013 – volume: 47 start-page: 1739 year: 2004 ident: ref_28 article-title: Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy publication-title: J. Med. Chem. doi: 10.1021/jm0306430 – ident: ref_27 doi: 10.1371/journal.pone.0159034 – volume: 42 start-page: 1951 year: 2021 ident: ref_30 article-title: Natural products: Potential treatments for cisplatin-induced nephrotoxicity publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-021-00620-9 – ident: ref_42 doi: 10.20944/preprints202306.1277.v1 – volume: 2019 start-page: 4916519 year: 2019 ident: ref_9 article-title: Nephroprotective effect of herbal extract Eurycoma longifolia on paracetamol-induced nephrotoxicity in rats publication-title: Evid.-Based Complement. Altern. Med. – volume: 13 start-page: 968226 year: 2022 ident: ref_34 article-title: Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.968226 – volume: 4 start-page: 118 year: 2010 ident: ref_44 article-title: Free radicals, antioxidants and functional foods: Impact on human health publication-title: Pharmacogn. Rev. doi: 10.4103/0973-7847.70902 – volume: 9 start-page: e59038 year: 2020 ident: ref_25 article-title: Molecular principles of assembly, activation, and inhibition in epithelial sodium channel publication-title: Elife doi: 10.7554/eLife.59038 – volume: 85 start-page: 322 year: 2023 ident: ref_37 article-title: Toxicity of acephate to liver and kidney of female wistar rats publication-title: Indian J. Entomol. – ident: ref_48 doi: 10.3390/nu14142867 – volume: 3 start-page: 368 year: 2013 ident: ref_2 article-title: Risk factors for chronic kidney disease: An update publication-title: Kidney Int. Suppl. doi: 10.1038/kisup.2013.79 – volume: 105 start-page: 121 year: 1984 ident: ref_19 article-title: Catalase in vitro publication-title: Methods Enzymol. doi: 10.1016/S0076-6879(84)05016-3 – volume: 72 start-page: 248 year: 1976 ident: ref_21 article-title: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding publication-title: Anal. Biochem. doi: 10.1016/0003-2697(76)90527-3 – ident: ref_39 doi: 10.1016/j.fbio.2023.102657 – ident: ref_40 doi: 10.3390/nu14112338 – volume: 10 start-page: 353 year: 2023 ident: ref_41 article-title: Antioxidant phenolic compounds from seeds of Hordeum vulgare Linn. ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats publication-title: J. Tradit. Chin. Med. Sci. – volume: 13 start-page: 201 year: 2017 ident: ref_53 article-title: Heparanase: Roles in cell survival, extracellular matrix remodelling and the development of kidney disease publication-title: Nat. Rev. Nephrol. doi: 10.1038/nrneph.2017.6 – ident: ref_29 – volume: 37 start-page: 2639 year: 2022 ident: ref_35 article-title: Evaluation of protective effects of quercetin against cypermethrin-induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway publication-title: Environ. Toxicol. doi: 10.1002/tox.23624 – volume: 2022 start-page: 8440019 year: 2022 ident: ref_10 article-title: Nephroprotective effect of asparagus africanus lam. root extract against gentamicin-induced nephrotoxicity in swiss albino mice publication-title: J. Toxicol. – ident: ref_26 doi: 10.1101/2020.01.22.909879 – ident: ref_33 doi: 10.3390/molecules27072365 – volume: 27 start-page: 26036 year: 2020 ident: ref_31 article-title: Organophosphate toxicity: Updates of malathion potential toxic effects in mammals and potential treatments publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-020-08937-4 – volume: 15 start-page: 104037 year: 2022 ident: ref_16 article-title: Millettia ferruginea extract attenuates cisplatin-induced alterations in kidney functioning, DNA damage, oxidative stress, and renal tissue morphology publication-title: Arab. J. Chem. doi: 10.1016/j.arabjc.2022.104037 – volume: 38 start-page: 1535 year: 2023 ident: ref_50 article-title: Carvacrol protects against λ-Cyhalothrin-induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy publication-title: Environ. Toxicol. doi: 10.1002/tox.23784 – volume: 29 start-page: 14111 year: 2022 ident: ref_46 article-title: Bromuconazole caused genotoxicity and hepatic and renal damage via oxidative stress process in Wistar rats publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-021-16091-8 – volume: 447 start-page: 152636 year: 2021 ident: ref_5 article-title: Biochemical and histopathological responses in peripubertal male rats exposed to agrochemicals isolated or in combination: A multivariate data analysis study publication-title: Toxicology doi: 10.1016/j.tox.2020.152636
SSID	ssj0000651684
Score	2.287883
Snippet	The aim of the current work was to examine for the first time the nephropreventive capacity of Ephedra alata seed extract (E) against maternal exposure to... The aim of the current work was to examine for the first time the nephropreventive capacity of seed extract (E) against maternal exposure to acephate in rat...
SourceID	doaj proquest pubmed crossref
SourceType	Open Website Aggregation Database Index Database Enrichment Source
StartPage	2254
SubjectTerms	acephate Antioxidants Autophagy Bioactive compounds Biomarkers Creatinine DNA fragmentation Drug dosages Ephedra Ephedra alata Exposure Fatty acids Gene expression Genes Immunofluorescence Kidney diseases Kidneys Laboratory animals Lipid peroxidation Lipids Molecular docking Na+/H+-exchanging ATPase Na+/K+-exchanging ATPase nephrotoxicity Offspring Oxidative stress Peroxidation Pesticides Phytochemicals Proteins Risk factors Seeds Sodium Stress analysis Uric acid
SummonAdditionalLinks	– databaseName: DOAJ: Directory of Open Access Journal (DOAJ) dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxELZQBVIviEcLgYIGiZ5Q1H3Ea_sYUCoQVal4qbfV2J5tI0WbKNmg5j_woxnb2ygcKi5c13PwzozX37f2fCPEW6cLYw2Fsg_NBMUz3bHG4XCEQf3MG1XG-oqfZ-r8XF9emoudVl_hTliSB06OO8nJETLTzqwNZzy5NtaH4y_UVPiKYukeo54dMpW-wTKv9CjddC-Z15_Mpg3lZR7ozeivPShK9d-NL-M-c_pIPOwBIozTxB6Le9Q-EQ9Sy8jNU_F7srgmv0TAGXYI33jzWUEq24PPU9_SBi6S9AI7HPCKif-qgyhjDGc8OZjcLObhryB0cxg7Wlwz2AS7ga-pKT3vZPDlZuqjHjh8CjfVO8DWs21qhMbj43VQI8CrzYH4cTr5_uHjsO-oMHQMm7phk1U-9wz6CCtFmVbs06YprGMcFI_smAxljUGDVpJGzcbSSWMz12iG4a48FHvtvKXnAkhlzihbGscMzhqLJXrD5M2hcw1SORDvbn1cu15uPHS9mNVMO0JE6t2IDMTx1nqRZDbusHsfwrW1CeLY8QGnTN2nTP2vlBmIo9tg1_2KXdWFyUaqYgSoBuLNdpjXWjhAwZbm62gjmbjLit_uWUqS7UwY-ZRKS_nif8zwpdgPbe1DzWMhj8Ret1zTK3Hf_eqmq-XrmOp_AABlBGQ priority: 102 providerName: Directory of Open Access Journals
Title	Ephedra alata Seeds Confer Kidney Protection against Early Life Exposure to Acephate by Regulating Oxidative Insult and Activating Autophagy
URI	https://www.ncbi.nlm.nih.gov/pubmed/38137855 https://www.proquest.com/docview/2904760257 https://www.proquest.com/docview/2905523563 https://doaj.org/article/1ecea1940bb5458189bd0035a8e2d6e9
Volume	13
WOSCitedRecordID	wos001132168600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database (ProQuest) customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: M7P dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: PATMY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: BENPR dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2075-1729 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000651684 issn: 2075-1729 databaseCode: PIMPY dateStart: 20110101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZoCxIX3oWFsjISnFDUvG2f0BZtRUVZovLQcorGj2wjrZKwm0Xd_8CPZuxkAxzKhaszihyNnfm-GfsbQl4qHgopjL32wZGgaKQ7UijwYrDqZ1qwyN2v-HrOZjM-n4usT7it-2OVu3-i-1HrWtkc-XEo_JilGKHZm-a7Z7tG2epq30JjjxxYlYTIHd3LhhwLhtcg5XF33j1Cdn-8LAsTRIElOfFfkcgJ9l-PMl20Ob37v_O8R-70OJNOuoVxn9ww1QNyq-s8uX1Ifk6bS6NXQGEJLdBPGMPWtLv9R9-XujJbmnUKDug3CgsoEUZSp4ZMz_Hr6PSqqW1ykbY1nSjTXCJmpXJLL7re9hgQ6cerUjtZcXpmD7y3FCqNtl0_NXw-2VhRA1hsH5Evp9PPb995fWMGTyH6ar3CT3WgETsaSJnxOZNJXBShVAinXOUPOZVfCBAgE8OBo3GiEiF9VXBE8yo6JPtVXZknhBrmK8FkJBQSQSkkRKAFckAFShVgohF5vXNSrnrVcts8Y5kje7Euzf906Yi8GqybTq3jGrsT6-_Bxmpsu4F6tcj7LZsHRhkIROxLaauLARdS28IrcBPq1IgROdqtgLzf-Ov8t_tH5MXwGLesrcNAZeqNs0mQ_ycpft3jbpUNM0EAFTGeJE___fJn5Lbte28vRYbJEdlvVxvznNxUP9pyvRqTPTbnY3JwMp1lF2OXZhi7nYFj2dmH7NsvQyUXlA
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFAQX3rSBAotET8iq3949IBQgVaOkIYKCysnMPpxGiuyQOND8B34Lv5FZ2wlwKLceuNojK15_mfm-nZ0ZgOeK-0IKY8s-OAkUTXJHCoVOiLb7mRZJUNVXfBokwyE_PRWjLfi5roWxxyrXPrFy1LpQdo_8wBdumMQUoZNXs6-OnRpls6vrERo1LPpm9Z0k2-Jl7y19333fP-yevDlymqkCjiLqUDqZG2tPE_ExGCfG5YmMwizzpSIuUKWtSBC4mUCBMjIcORlHKhLSVRknKqoCeu4V2A4J7LwF26Pe8ejzZleHAroX87A-YR8Ewj2YTjLjBZ6VVeFfsa8aEXAxr63i2-Gt_21lbsPNhkmzTg39O7Bl8rtwrZ6tuboHP7qzM6PnyHCKJbIPFKUXrK5vZP2Jzs2KjeoeFYRMhmOcEFFmVb9nNqDVZN3zWWG3T1lZsI4yszNi5Uyu2Hszrkae5WP27nyiq8bprGeP9JcMc0229cQ4ut9Z2rYNOF7dh4-XshQPoJUXudkFZhJXiUQGQpHUlUJigFqQylWoVIYmaMOLNShS1fRlt-NBpinpMwuh9E8ItWF_Yz2r-5FcYPfa4mtjY7uIVxeK-ThtnFLqGWXQE6Erpc2felxIbVPLyI2vYyPasLdGXNq4tkX6G25teLa5TU7JZpowN8WysokiP4hierudGtWbX0IUMUh4FD3898OfwvWjk-NBOugN-4_ghk_c0paA-tEetMr50jyGq-pbOVnMnzT_QQZfLhvcvwBQXHCw
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VFhAX3o9AgUWiJ2TFr7V3DwgFmogoIURQqnIysw-7liI7JA40_4FfxK9j1nYCHMqtB672yIo3n2e-2dn5hpDnivtCCmPbPjgmKBrTHSkUOCFY9TMt4qDurzgex5MJPzkR0x3yc9MLY49Vbnxi7ah1qeweedcXbhhHGKHjbtoei5geDl7Nvzp2gpSttG7GaTQQGZn1d0zfli-Hh_hfH_j-oH_05q3TThhwFNKIykndSHsaSZCBKDYujyUL09SXCnlBXcLC5MBNBQiQzHDgaMwUE9JVKUdaqgJ87iWyZzXi0CnsTXtH7z5vd3gwuHsRD5vT9kEg3O4sT40XeDbFCv-Kg_W4gPM5bh3rBjf-51W6Sa63DJv2mk_iFtkxxW1ypZm5ub5DfvTnp0YvgMIMKqAfMXovadP3SEe5LsyaThvtCkQshQxyJNC01oGmY1xZ2j-bl3ZblVYl7SkzP0W2TuWafjBZPQqtyOj7s1zXgup0aI_6VxQKjbbNJDm831tZOQfI1nfJpwtZintktygL84BQE7tKxDIQClNgKSQEoAVmvwqUSsEEHfJiA5BEtXrtdmzILMG8zcIp-RNOHXKwtZ43OiXn2L22WNvaWHXx-kK5yJLWWSWeUQY8EbpS2rqqx4XUtuQM3Pg6MqJD9jfoS1qXt0x-Q69Dnm1vo7OyFSgoTLmqbRjzAxbh291vEL79JUgdg5gz9vDfD39KriKik_FwMnpErvlIOW1nqM_2yW61WJnH5LL6VuXLxZP2c6Tky0Vj-xcd2Xlm
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ephedra+alata+Seeds+Confer+Kidney+Protection+against+Early+Life+Exposure+to+Acephate+by+Regulating+Oxidative+Insult+and+Activating+Autophagy&rft.jtitle=Life+%28Basel%2C+Switzerland%29&rft.au=Mufti%2C+Afoua&rft.au=Feriani%2C+Anouar&rft.au=Contreras%2C+Mar%C3%ADa+Del+Mar&rft.au=Nehdi%2C+Saber&rft.date=2023-11-25&rft.issn=2075-1729&rft.eissn=2075-1729&rft.volume=13&rft.issue=12&rft_id=info:doi/10.3390%2Flife13122254&rft_id=info%3Apmid%2F38137855&rft.externalDocID=38137855
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2075-1729&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2075-1729&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2075-1729&client=summon