Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development

Prior reports have demonstrated that both parathyroid hormone-related protein (PTHrP) and the type I PTH/PTHrP receptor are necessary for the proper development of the embryonic mammary gland in mice. Using a combination of loss-of-function and gain-of-function models, we now report that PTHrP regul...

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Veröffentlicht in:	Development (Cambridge) Jg. 128; H. 4; S. 513
Hauptverfasser:	Foley, J, Dann, P, Hong, J, Cosgrove, J, Dreyer, B, Rimm, D, Dunbar, M, Philbrick, W, Wysolmerski, J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 15.02.2001
Schlagworte:	Animals beta Catenin Cell Differentiation Cell Lineage Cytoskeletal Proteins - analysis DNA-Binding Proteins - analysis Epidermal Cells Epidermis - embryology Epithelial Cells - cytology Female Gene Expression Regulation, Developmental Histocytochemistry Lymphoid Enhancer-Binding Factor 1 Mammary Glands, Animal - cytology Mammary Glands, Animal - embryology Mice Mice, Knockout Mice, Transgenic Models, Biological Nipples - cytology Nipples - embryology Parathyroid Hormone-Related Protein Proteins - genetics Proteins - metabolism Receptor, Parathyroid Hormone, Type 1 Receptors, Parathyroid Hormone - genetics Receptors, Parathyroid Hormone - metabolism Signal Transduction Trans-Activators Transcription Factors - analysis Transgenes - genetics
ISSN:	0950-1991
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