Cardiovascular disease and thinning of retinal nerve fiber layer in a multi-ethnic Asian population: the Singapore epidemiology of eye diseases study

IntroductionOur study aimed to examine the relationship between cardiovascular diseases (CVD) with peripapillary retinal fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thickness profiles in a large multi-ethnic Asian population study.Methods6,024 Asian subjects were analy...

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Vydané v:	Frontiers in medicine Ročník 10; s. 1235309
Hlavní autori:	Majithia, Shivani, Quek, Debra Q. Y., Chee, Miao Li, Lim, Zhi Wei, Nusinovici, Simon, Soh, Zhi-Da, Thakur, Sahil, Rim, Tyler Hyungtaek, Sabanayagam, Charumathi, Cheng, Ching-Yu, Tham, Yih-Chung
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Lausanne Frontiers Media SA 19.10.2023 Frontiers Media S.A
Predmet:	Alcohol Algorithms Angina pectoris Asian Blood pressure Body mass index Cardiovascular disease Diabetes Epidemiology Eye diseases ganglion cell-inner plexiform Glaucoma Hyperlipidemia Hypertension Kidney diseases Medical history Medicine Minority & ethnic groups Optic nerve optical coherence tomography Response rates retinal nerve fiber layer Self report Software Singapore
ISSN:	2296-858X, 2296-858X
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Shrnutí:	IntroductionOur study aimed to examine the relationship between cardiovascular diseases (CVD) with peripapillary retinal fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thickness profiles in a large multi-ethnic Asian population study.Methods6,024 Asian subjects were analyzed in this study. All participants underwent standardized examinations, including spectral domain OCT imaging (Cirrus HD-OCT; Carl Zeiss Meditec). In total, 9,188 eyes were included for peripapillary RNFL analysis (2,417 Malays; 3,240 Indians; 3,531 Chinese), and 9,270 eyes (2,449 Malays, 3,271 Indians, 3,550 Chinese) for GCIPL analysis. History of CVD was defined as a self-reported clinical history of stroke, myocardial infarction, or angina. Multivariable linear regression models with generalized estimating equations were performed, adjusting for age, gender, ethnicity, diabetes, hypertension, hyperlipidaemia, chronic kidney disease, body mass index, current smoking status, and intraocular pressure.ResultsWe observed a significant association between CVD history and thinner average RNFL (β = −1.63; 95% CI, −2.70 to −0.56; p = 0.003). This association was consistent for superior (β = −1.79, 95% CI, −3.48 to −0.10; p = 0.038) and inferior RNFL quadrant (β = −2.14, 95% CI, −3.96 to −0.32; p = 0.021). Of the CVD types, myocardial infarction particularly showed significant association with average (β = −1.75, 95% CI, −3.08 to −0.42; p = 0.010), superior (β = −2.22, 95% CI, −4.36 to −0.09; p = 0.041) and inferior (β = −2.42, 95% CI, −4.64 to −0.20; p = 0.033) RNFL thinning. Among ethnic groups, the association between CVD and average RNFL was particularly prominent in Indian eyes (β = −1.92, 95% CI, −3.52 to −0.33; p = 0.018). CVD was not significantly associated with average GCIPL thickness, albeit a consistent negative direction of association was observed (β = −0.22, 95% CI, −1.15 to 0.71; p = 0.641).DiscussionIn this large multi-ethnic Asian population study, we observed significant association between CVD history and RNFL thinning. This finding further validates the impact of impaired systemic circulation on RNFL thickness.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors share last authorship Edited by: Jie Hao, Capital Medical University, China These authors share first authorship Reviewed by: Yingxin Yang, Capital Medical University, China; Changzheng Chen, Renmin Hospital of Wuhan University, China; Pengfei Zhang, Dalian University of Technology, China
ISSN:	2296-858X 2296-858X
DOI:	10.3389/fmed.2023.1235309