PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance

► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of UV-lesions. ► PCNA-Ub/ Polh independent DDT of UV-lesions involves Rev1 and Rev3. The generation of high affinity antibodies in B cells crit...

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Vydáno v:	DNA repair Ročník 10; číslo 10; s. 1051 - 1059
Hlavní autoři:	Krijger, Peter H.L., van den Berk, Paul C.M., Wit, Niek, Langerak, Petra, Jansen, Jacob G., Reynaud, Claude-Agnès, de Wind, Niels, Jacobs, Heinz
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier B.V 10.10.2011 Elsevier
Témata:	Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Bacteriology Biological and medical sciences DNA Damage - genetics DNA damage tolerance DNA Repair - genetics DNA-Directed DNA Polymerase - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Growth, nutrition, cell differenciation Lysine - genetics Mice Mice, Inbred C57BL Microbiology Molecular and cellular biology Molecular genetics Mutagenesis Mutagenesis. Repair Mutation PCNA Polη Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Somatic hypermutation Somatic Hypermutation, Immunoglobulin - genetics Translesion synthesis Ubiquitination Ultraviolet Rays DNA damage tolerance Somatic hypermutation Ubiquitination PCNA Polη Translesion synthesis Immunoglobulins DNA Activation Lesion Repair
ISSN:	1568-7864, 1568-7856, 1568-7856
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