PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance

► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of UV-lesions. ► PCNA-Ub/ Polh independent DDT of UV-lesions involves Rev1 and Rev3. The generation of high affinity antibodies in B cells crit...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	DNA repair Ročník 10; číslo 10; s. 1051 - 1059
Hlavní autoři:	Krijger, Peter H.L., van den Berk, Paul C.M., Wit, Niek, Langerak, Petra, Jansen, Jacob G., Reynaud, Claude-Agnès, de Wind, Niels, Jacobs, Heinz
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier B.V 10.10.2011 Elsevier
Témata:	Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Bacteriology Biological and medical sciences DNA Damage - genetics DNA damage tolerance DNA Repair - genetics DNA-Directed DNA Polymerase - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Growth, nutrition, cell differenciation Lysine - genetics Mice Mice, Inbred C57BL Microbiology Molecular and cellular biology Molecular genetics Mutagenesis Mutagenesis. Repair Mutation PCNA Polη Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Somatic hypermutation Somatic Hypermutation, Immunoglobulin - genetics Translesion synthesis Ubiquitination Ultraviolet Rays DNA damage tolerance Somatic hypermutation Ubiquitination PCNA Polη Translesion synthesis Immunoglobulins DNA Activation Lesion Repair
ISSN:	1568-7864, 1568-7856, 1568-7856
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of UV-lesions. ► PCNA-Ub/ Polh independent DDT of UV-lesions involves Rev1 and Rev3. The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase η (Polη)-deficient, PCNA K164R-mutant, and PCNA K164R;Polη double-mutant mice, we now find that most PCNA-Ub-independent A/T mutagenesis during SHM is mediated by Polη. In addition, upon exposure to various DNA damaging agents, PCNA K164R mutant cells display strongly impaired recruitment of TLS polymerases, reduced daughter strand maturation and hypersensitivity. Interestingly, compared to the single mutants, PCNA K164R;Polη double-mutant cells are dramatically delayed in S phase progression and far more prone to cell death following UV exposure. Taken together, these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Polη during SHM and DNA damage tolerance.
AbstractList	The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase η (Polη)-deficient, PCNA(K164R)-mutant, and PCNA(K164R);Polη double-mutant mice, we now find that most PCNA-Ub-independent A/T mutagenesis during SHM is mediated by Polη. In addition, upon exposure to various DNA damaging agents, PCNA(K164R) mutant cells display strongly impaired recruitment of TLS polymerases, reduced daughter strand maturation and hypersensitivity. Interestingly, compared to the single mutants, PCNA(K164R);Polη double-mutant cells are dramatically delayed in S phase progression and far more prone to cell death following UV exposure. Taken together, these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Polη during SHM and DNA damage tolerance.The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase η (Polη)-deficient, PCNA(K164R)-mutant, and PCNA(K164R);Polη double-mutant mice, we now find that most PCNA-Ub-independent A/T mutagenesis during SHM is mediated by Polη. In addition, upon exposure to various DNA damaging agents, PCNA(K164R) mutant cells display strongly impaired recruitment of TLS polymerases, reduced daughter strand maturation and hypersensitivity. Interestingly, compared to the single mutants, PCNA(K164R);Polη double-mutant cells are dramatically delayed in S phase progression and far more prone to cell death following UV exposure. Taken together, these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Polη during SHM and DNA damage tolerance. The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase eta (Pol eta )-deficient, PCNAK164R-mutant, and PCNAK164R; Pol eta double-mutant mice, we now find that most PCNA-Ub-independent A/T mutagenesis during SHM is mediated by Pol eta . In addition, upon exposure to various DNA damaging agents, PCNAK164R mutant cells display strongly impaired recruitment of TLS polymerases, reduced daughter strand maturation and hypersensitivity. Interestingly, compared to the single mutants, PCNAK164R; Pol eta double-mutant cells are dramatically delayed in S phase progression and far more prone to cell death following UV exposure. Taken together, these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Pol eta during SHM and DNA damage tolerance. ► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of UV-lesions. ► PCNA-Ub/ Polh independent DDT of UV-lesions involves Rev1 and Rev3. The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase η (Polη)-deficient, PCNA K164R-mutant, and PCNA K164R;Polη double-mutant mice, we now find that most PCNA-Ub-independent A/T mutagenesis during SHM is mediated by Polη. In addition, upon exposure to various DNA damaging agents, PCNA K164R mutant cells display strongly impaired recruitment of TLS polymerases, reduced daughter strand maturation and hypersensitivity. Interestingly, compared to the single mutants, PCNA K164R;Polη double-mutant cells are dramatically delayed in S phase progression and far more prone to cell death following UV exposure. Taken together, these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Polη during SHM and DNA damage tolerance. The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into immunoglobulin genes during somatic hypermutation (SHM). The majority of mutations at A/T base pairs during SHM require ubiquitination of PCNA at lysine 164 (PCNA-Ub), which activates TLS polymerases. By comparing the mutation spectra in B cells of WT, TLS polymerase η (Polη)-deficient, PCNA(K164R)-mutant, and PCNA(K164R);Polη double-mutant mice, we now find that most PCNA-Ub-independent A/T mutagenesis during SHM is mediated by Polη. In addition, upon exposure to various DNA damaging agents, PCNA(K164R) mutant cells display strongly impaired recruitment of TLS polymerases, reduced daughter strand maturation and hypersensitivity. Interestingly, compared to the single mutants, PCNA(K164R);Polη double-mutant cells are dramatically delayed in S phase progression and far more prone to cell death following UV exposure. Taken together, these data support the existence of PCNA ubiquitination-dependent and -independent activation pathways of Polη during SHM and DNA damage tolerance.
Author	van den Berk, Paul C.M. Jacobs, Heinz Langerak, Petra Reynaud, Claude-Agnès Wit, Niek Jansen, Jacob G. Krijger, Peter H.L. de Wind, Niels
Author_xml	– sequence: 1 givenname: Peter H.L. surname: Krijger fullname: Krijger, Peter H.L. organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands – sequence: 2 givenname: Paul C.M. surname: van den Berk fullname: van den Berk, Paul C.M. organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands – sequence: 3 givenname: Niek surname: Wit fullname: Wit, Niek organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands – sequence: 4 givenname: Petra surname: Langerak fullname: Langerak, Petra organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands – sequence: 5 givenname: Jacob G. surname: Jansen fullname: Jansen, Jacob G. organization: Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands – sequence: 6 givenname: Claude-Agnès surname: Reynaud fullname: Reynaud, Claude-Agnès organization: Institut National de la Santé et de la Recherche Médicale U783 ‘Développement du système immunitaire’, Université Paris Descartes, Faculté de Médecine, Site Necker-Enfants Malades, Paris, France – sequence: 7 givenname: Niels surname: de Wind fullname: de Wind, Niels organization: Department of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands – sequence: 8 givenname: Heinz surname: Jacobs fullname: Jacobs, Heinz email: h.jacobs@nki.nl organization: Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24603792$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21889916$$D View this record in MEDLINE/PubMed
BookMark	eNqFkc1u1DAUhS1URH_gDRDyBrFKsJ3EsVkgVVP-pApYwNqyneviUeJk7KTSPBlv0WfCQ4YisaCbe6-s7xzJ55yjkzAGQOg5JSUllL_ell3QEaaSEUpLIkpCmkfojDZcFK1o-Mn9zetTdJ7SlhDatJw_QaeMCiEl5Wdo93Xz-RIvxu8WP_ugZz-GwocOJsgjzFjb2d_-fsajw9PY7weIOgG--4m7Jfpwg9M4ZMDiH_sJ4rDMK61Dh6-yd6cHfQN4HvusCxaeosdO9wmeHfcF-v7-3bfNx-L6y4dPm8vrwtasmgtZybYFqaUwVrREWE6dcTUzWrDaaVJJURvJLOOGtMIZa6zLl9EV7cA1orpAr1bfKY67BdKsBp8s9L0OMC5JScKqpm5F9SApJGc1YZRm8sWRXMwAnZqiH3Tcqz95ZuDlEdDJ6t4dfuzTX67mpGoly1y9cjaOKUVw9wgl6lCv2qq1XnWoVxGhcr1Z9uYfmfVr3HPUvn9I_HYVQ0791kNUyXrIjXQ-gp1VN_r_G_wC6NXE5A
CitedBy_id	crossref_primary_10_1124_mol_114_093211 crossref_primary_10_1002_eji_201243191 crossref_primary_10_1002_em_21741 crossref_primary_10_1093_nar_gkac545 crossref_primary_10_1016_j_molcel_2016_12_020 crossref_primary_10_1016_j_dnarep_2015_11_011 crossref_primary_10_1093_nar_gkt016 crossref_primary_10_1093_nar_gkv712 crossref_primary_10_1038_s41594_020_0418_4 crossref_primary_10_1093_nar_gkt793 crossref_primary_10_1093_nar_gku1301 crossref_primary_10_1016_j_bmc_2013_01_022 crossref_primary_10_1093_nar_gkw123 crossref_primary_10_1371_journal_pone_0210526 crossref_primary_10_1093_nar_gkz531 crossref_primary_10_1074_jbc_M112_380998 crossref_primary_10_3389_fgene_2016_00105 crossref_primary_10_3389_fimmu_2019_00438 crossref_primary_10_3389_fimmu_2022_986863 crossref_primary_10_3389_fimmu_2018_00355 crossref_primary_10_1371_journal_pgen_1007119 crossref_primary_10_3389_fimmu_2021_807015 crossref_primary_10_1016_j_smim_2012_05_002 crossref_primary_10_1073_pnas_1706508114 crossref_primary_10_1080_10409238_2019_1687420 crossref_primary_10_3389_fchem_2020_00111 crossref_primary_10_1016_j_biopha_2011_09_001 crossref_primary_10_1016_j_dnarep_2016_12_008 crossref_primary_10_1093_nar_gkae918 crossref_primary_10_1186_s13059_024_03451_z crossref_primary_10_7554_eLife_19788 crossref_primary_10_1038_ncomms13326 crossref_primary_10_3390_genes15101271 crossref_primary_10_1016_j_dnarep_2012_03_007 crossref_primary_10_1371_journal_pone_0036004 crossref_primary_10_1242_jcs_094748
Cites_doi	10.1016/0076-6879(93)25052-4 10.1016/j.dnarep.2009.09.006 10.1084/jem.187.11.1745 10.1016/j.molcel.2004.10.011 10.1073/pnas.0809844105 10.1074/jbc.M709275200 10.1016/j.jmb.2010.09.015 10.1038/nature00991 10.1084/jem.20071768 10.1038/21447 10.1002/j.1460-2075.1991.tb07953.x 10.1016/j.dnarep.2008.05.012 10.1146/annurev-genet-051710-150955 10.1093/emboj/cdg626 10.1084/jem.20062131 10.1093/nar/gkr420 10.1038/ni1031 10.1084/jem.20070902 10.1101/gad.187501 10.1038/nrm1781 10.1128/MCB.00071-09 10.1084/jem.20050292 10.1371/journal.pbio.0040366 10.1084/jem.20052227 10.1038/sj.emboj.7600383 10.1073/pnas.231611798 10.4049/jimmunol.0901240 10.1016/S1074-7613(00)80595-6 10.1073/pnas.0501852102 10.1038/88740 10.1084/jem.20091707 10.1093/carcin/22.2.233 10.1073/pnas.0802727105 10.1126/science.1120615 10.1093/nar/gkn651 10.1242/jcs.00162 10.1084/jem.191.3.579 10.1074/jbc.C100569200 10.1007/s00018-009-0024-4 10.1016/S0960-9822(02)01215-0 10.1093/nar/gkp632 10.1016/j.molcel.2006.05.038 10.1074/jbc.C300023200 10.1093/nar/25.10.1913 10.1016/j.molcel.2008.03.024 10.1002/cyto.a.20839 10.1093/hmg/ddq046 10.1093/carcin/23.6.959 10.1016/S1097-2765(04)00259-X 10.1038/nature01965 10.1038/emboj.2008.281 10.1093/nar/gnh154 10.1021/bi000130k 10.1073/pnas.0808182105 10.1126/science.283.5404.1001 10.1016/j.molimm.2005.09.017 10.1091/mbc.E08-07-0724 10.1038/nature02352 10.1146/annurev.biochem.76.061705.090740 10.4049/jimmunol.0900177
ContentType	Journal Article
Copyright	2011 Elsevier B.V. 2015 INIST-CNRS Copyright © 2011 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2011 Elsevier B.V. – notice: 2015 INIST-CNRS – notice: Copyright © 2011 Elsevier B.V. All rights reserved.
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7TM 8FD FR3 P64 RC3
DOI	10.1016/j.dnarep.2011.08.005
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Nucleic Acids Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts Genetics Abstracts
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Genetics Abstracts Engineering Research Database Technology Research Database Nucleic Acids Abstracts Biotechnology and BioEngineering Abstracts
DatabaseTitleList	MEDLINE - Academic Genetics Abstracts MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology Chemistry Biology
EISSN	1568-7856
EndPage	1059
ExternalDocumentID	21889916 24603792 10_1016_j_dnarep_2011_08_005 S1568786411002278
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M -~X .~1 0R~ 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AATCM AAXUO ABFNM ABFRF ABFYP ABGSF ABJNI ABLST ABMAC ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHEUO AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLECG BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ H~9 IH2 IHE J1W KCYFY KOM M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SEW SPCBC SSJ SSP SSU SSZ T5K ZGI ~G- 9DU AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS BNPGV IQODW SSH CGR CUY CVF ECM EIF NPM 7X8 7TM 8FD FR3 P64 RC3
ID	FETCH-LOGICAL-c423t-93977e9a98bc8708c61fbf42ba824fa03984b92c26b078fbcbcfb07ba31def583
ISICitedReferencesCount	40
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000296266900009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1568-7864 1568-7856
IngestDate	Sun Sep 28 03:47:13 EDT 2025 Wed Oct 01 15:01:58 EDT 2025 Mon Jul 21 06:03:13 EDT 2025 Mon Jul 21 09:13:58 EDT 2025 Sat Nov 29 06:20:51 EST 2025 Tue Nov 18 21:48:56 EST 2025 Fri Feb 23 02:32:40 EST 2024
IsPeerReviewed	true
IsScholarly	true
Issue	10
Keywords	DNA damage tolerance Somatic hypermutation Ubiquitination PCNA Polη Translesion synthesis Immunoglobulins DNA Activation Lesion Repair
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2011 Elsevier B.V. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c423t-93977e9a98bc8708c61fbf42ba824fa03984b92c26b078fbcbcfb07ba31def583
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
PMID	21889916
PQID	896240211
PQPubID	23479
PageCount	9
ParticipantIDs	proquest_miscellaneous_902354783 proquest_miscellaneous_896240211 pubmed_primary_21889916 pascalfrancis_primary_24603792 crossref_primary_10_1016_j_dnarep_2011_08_005 crossref_citationtrail_10_1016_j_dnarep_2011_08_005 elsevier_sciencedirect_doi_10_1016_j_dnarep_2011_08_005
PublicationCentury	2000
PublicationDate	2011-10-10
PublicationDateYYYYMMDD	2011-10-10
PublicationDate_xml	– month: 10 year: 2011 text: 2011-10-10 day: 10
PublicationDecade	2010
PublicationPlace	Amsterdam
PublicationPlace_xml	– name: Amsterdam – name: Netherlands
PublicationTitle	DNA repair
PublicationTitleAlternate	DNA Repair (Amst)
PublicationYear	2011
Publisher	Elsevier B.V Elsevier
Publisher_xml	– name: Elsevier B.V – name: Elsevier
References	Hoege, Pfander, Moldovan, Pyrowolakis, Jentsch (bib0105) 2002; 419 Kannouche, Broughton, Volker, Hanaoka, Mullenders, Lehmann (bib0200) 2001; 15 Adar, Izhar, Hendel, Geacintov, Livneh (bib0295) 2009; 37 Rolink, Kudo, Karasuyama, Kikuchi, Melchers (bib0150) 1991; 10 McCulloch, Kokoska, Masutani, Iwai, Hanaoka, Kunkel (bib0275) 2004; 428 Phung, Winter, Cranston, Tarone, Bohr, Fishel, Gearhart (bib0020) 1998; 187 Guo, Kosarek-Stancel, Tang, Friedberg (bib0195) 2009; 66 Heyer, Ehmsen, Liu (bib0290) 2010; 44 Choi, Lim, Kim, Jo, Guengerich (bib0065) 2010; 404 Martomo, Yang, Wersto, Ohkumo, Kondo, Yokoi, Masutani, Hanaoka, Gearhart (bib0190) 2005; 102 Johnson, Prakash, Prakash (bib0100) 1999; 283 Di Noia, Neuberger (bib0005) 2007; 76 Niimi, Brown, Sabbioneda, Kannouche, Scott, Yasui, Green, Lehmann (bib0120) 2008; 105 Bergoglio, Bavoux, Verbiest, Hoffmann, Cazaux (bib0205) 2002; 115 Zeng, Winter, Kasmer, Kraemer, Lehmann, Gearhart (bib0055) 2001; 2 Rada, Ehrenstein, Neuberger, Milstein (bib0025) 1998; 9 Szuts, Marcus, Himoto, Iwai, Sale (bib0280) 2008; 36 Masuda, Ouchida, Li, Gao, Mori, Wang (bib0080) 2009; 183 Stelter, Ulrich (bib0110) 2003; 425 Zhao, Traganos, Darzynkiewicz (bib0240) 2010; 77 Abbondanzo, Gadi, Stewart (bib0155) 1993; 225 Jansen, Tsaalbi-Shtylik, Hendriks, Gali, Hendel, Johansson, Erixon, Livneh, Mullenders, Haracska, de Wind (bib0180) 2009; 29 Ross, Sale (bib0075) 2006; 43 Di Noia, Williams, Chan, Buerstedde, Baldwin, Neuberger (bib0010) 2007; 204 Rada, Williams, Nilsen, Barnes, Lindahl, Neuberger (bib0060) 2002; 12 Bullock, Kaufmann, Cordeiro-Stone (bib0250) 2001; 22 Guo, Sonoda, Tang, Parker, Bielen, Takeda, Ulrich, Friedberg (bib0175) 2006; 23 Sabbioneda, Gourdin, Green, Zotter, Giglia-Mari, Houtsmuller, Vermeulen, Lehmann (bib0260) 2008; 19 Rada, Di Noia, Neuberger (bib0015) 2004; 16 Jansen, Tsaalbi-Shtylik, Hendriks, Verspuy, Gali, Haracska, de Wind (bib0185) 2009; 8 Roa, Avdievich, Peled, Maccarthy, Werling, Kuang, Kan, Zhao, Bergman, Cohen, Edelmann, Scharff (bib0140) 2008; 105 Edmunds, Simpson, Sale (bib0145) 2008; 30 Delbos, De Smet, Faili, Aoufouchi, Weill, Reynaud (bib0040) 2005; 201 Faili, Stary, Delbos, Weller, Aoufouchi, Sarasin, Weill, Reynaud (bib0050) 2009; 182 Delbos, Aoufouchi, Faili, Weill, Reynaud (bib0085) 2007; 204 Masutani, Kusumoto, Yamada, Dohmae, Yokoi, Yuasa, Araki, Iwai, Takio, Hanaoka (bib0095) 1999; 399 Shachar, Ziv, Avkin, Adar, Wittschieben, Reissner, Chaney, Friedberg, Wang, Carell, Geacintov, Livneh (bib0270) 2009; 28 Elvers, Johansson, Groth, Erixon, Helleday (bib0230) 2011 Acharya, Yoon, Gali, Unk, Haracska, Johnson, Hurwitz, Prakash, Prakash (bib0165) 2008; 105 Gueranger, Stary, Aoufouchi, Faili, Sarasin, Reynaud, Weill (bib0215) 2008; 7 Jansen, Langerak, Tsaalbi-Shtylik, van den Berk, Jacobs, de Wind (bib0070) 2006; 203 Guo, Fischhaber, Luk-Paszyc, Masuda, Zhou, Kamiya, Kisker, Friedberg (bib0285) 2003; 22 Bardwell, Woo, Wei, Li, Martin, Sack, Parris, Edelmann, Scharff (bib0045) 2004; 5 Dirac, Bernards (bib0160) 2003; 278 Johansson, Lagerqvist, Erixon, Jenssen (bib0220) 2004; 32 Cordeiro-Stone, Frank, Bryant, Oguejiofor, Hatch, McDaniel, Kaufmann (bib0255) 2002; 23 Vaisman, Masutani, Hanaoka, Chaney (bib0265) 2000; 39 Bienko, Green, Crosetto, Rudolf, Zapart, Coull, Kannouche, Wider, Peter, Lehmann, Hofmann, Dikic (bib0210) 2005; 310 Jolly, Klix, Neuberger (bib0300) 1997; 25 Limoli, Giedzinski, Bonner, Cleaver (bib0245) 2002; 99 Despras, Daboussi, Hyrien, Marheineke, Kannouche (bib0235) 2010; 19 Langerak, Nygren, Krijger, van den Berk, Jacobs (bib0135) 2007; 204 Watanabe, Tateishi, Kawasuji, Tsurimoto, Inoue, Yamaizumi (bib0125) 2004; 23 Kannouche, Wing, Lehmann (bib0130) 2004; 14 Guo, Tang, Bienko, Dikic, Friedberg (bib0170) 2008; 283 Friedberg (bib0090) 2005; 6 Ward, Chen (bib0225) 2001; 276 Wiesendanger, Kneitz, Edelmann, Scharff (bib0030) 2000; 191 Krijger, Langerak, van den Berk, Jacobs (bib0035) 2009; 206 Arakawa, Moldovan, Saribasak, Saribasak, Jentsch, Buerstedde (bib0115) 2006; 4 Bullock (10.1016/j.dnarep.2011.08.005_bib0250) 2001; 22 Johnson (10.1016/j.dnarep.2011.08.005_bib0100) 1999; 283 Kannouche (10.1016/j.dnarep.2011.08.005_bib0200) 2001; 15 McCulloch (10.1016/j.dnarep.2011.08.005_bib0275) 2004; 428 Rolink (10.1016/j.dnarep.2011.08.005_bib0150) 1991; 10 Szuts (10.1016/j.dnarep.2011.08.005_bib0280) 2008; 36 Heyer (10.1016/j.dnarep.2011.08.005_bib0290) 2010; 44 Despras (10.1016/j.dnarep.2011.08.005_bib0235) 2010; 19 Faili (10.1016/j.dnarep.2011.08.005_bib0050) 2009; 182 Krijger (10.1016/j.dnarep.2011.08.005_bib0035) 2009; 206 Delbos (10.1016/j.dnarep.2011.08.005_bib0040) 2005; 201 Jansen (10.1016/j.dnarep.2011.08.005_bib0070) 2006; 203 Jolly (10.1016/j.dnarep.2011.08.005_bib0300) 1997; 25 Choi (10.1016/j.dnarep.2011.08.005_bib0065) 2010; 404 Arakawa (10.1016/j.dnarep.2011.08.005_bib0115) 2006; 4 Di Noia (10.1016/j.dnarep.2011.08.005_bib0005) 2007; 76 Johansson (10.1016/j.dnarep.2011.08.005_bib0220) 2004; 32 Langerak (10.1016/j.dnarep.2011.08.005_bib0135) 2007; 204 Roa (10.1016/j.dnarep.2011.08.005_bib0140) 2008; 105 Di Noia (10.1016/j.dnarep.2011.08.005_bib0010) 2007; 204 Delbos (10.1016/j.dnarep.2011.08.005_bib0085) 2007; 204 Niimi (10.1016/j.dnarep.2011.08.005_bib0120) 2008; 105 Martomo (10.1016/j.dnarep.2011.08.005_bib0190) 2005; 102 Bardwell (10.1016/j.dnarep.2011.08.005_bib0045) 2004; 5 Friedberg (10.1016/j.dnarep.2011.08.005_bib0090) 2005; 6 Stelter (10.1016/j.dnarep.2011.08.005_bib0110) 2003; 425 Vaisman (10.1016/j.dnarep.2011.08.005_bib0265) 2000; 39 Dirac (10.1016/j.dnarep.2011.08.005_bib0160) 2003; 278 Adar (10.1016/j.dnarep.2011.08.005_bib0295) 2009; 37 Hoege (10.1016/j.dnarep.2011.08.005_bib0105) 2002; 419 Sabbioneda (10.1016/j.dnarep.2011.08.005_bib0260) 2008; 19 Rada (10.1016/j.dnarep.2011.08.005_bib0015) 2004; 16 Jansen (10.1016/j.dnarep.2011.08.005_bib0180) 2009; 29 Ward (10.1016/j.dnarep.2011.08.005_bib0225) 2001; 276 Limoli (10.1016/j.dnarep.2011.08.005_bib0245) 2002; 99 Phung (10.1016/j.dnarep.2011.08.005_bib0020) 1998; 187 Acharya (10.1016/j.dnarep.2011.08.005_bib0165) 2008; 105 Bergoglio (10.1016/j.dnarep.2011.08.005_bib0205) 2002; 115 Abbondanzo (10.1016/j.dnarep.2011.08.005_bib0155) 1993; 225 Bienko (10.1016/j.dnarep.2011.08.005_bib0210) 2005; 310 Kannouche (10.1016/j.dnarep.2011.08.005_bib0130) 2004; 14 Guo (10.1016/j.dnarep.2011.08.005_bib0195) 2009; 66 Ross (10.1016/j.dnarep.2011.08.005_bib0075) 2006; 43 Rada (10.1016/j.dnarep.2011.08.005_bib0025) 1998; 9 Shachar (10.1016/j.dnarep.2011.08.005_bib0270) 2009; 28 Guo (10.1016/j.dnarep.2011.08.005_bib0175) 2006; 23 Masuda (10.1016/j.dnarep.2011.08.005_bib0080) 2009; 183 Zhao (10.1016/j.dnarep.2011.08.005_bib0240) 2010; 77 Watanabe (10.1016/j.dnarep.2011.08.005_bib0125) 2004; 23 Wiesendanger (10.1016/j.dnarep.2011.08.005_bib0030) 2000; 191 Masutani (10.1016/j.dnarep.2011.08.005_bib0095) 1999; 399 Zeng (10.1016/j.dnarep.2011.08.005_bib0055) 2001; 2 Rada (10.1016/j.dnarep.2011.08.005_bib0060) 2002; 12 Elvers (10.1016/j.dnarep.2011.08.005_bib0230) 2011 Guo (10.1016/j.dnarep.2011.08.005_bib0170) 2008; 283 Jansen (10.1016/j.dnarep.2011.08.005_bib0185) 2009; 8 Edmunds (10.1016/j.dnarep.2011.08.005_bib0145) 2008; 30 Guo (10.1016/j.dnarep.2011.08.005_bib0285) 2003; 22 Gueranger (10.1016/j.dnarep.2011.08.005_bib0215) 2008; 7 Cordeiro-Stone (10.1016/j.dnarep.2011.08.005_bib0255) 2002; 23
References_xml	– volume: 105 start-page: 17724 year: 2008 end-page: 17729 ident: bib0165 article-title: Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 399 start-page: 700 year: 1999 end-page: 704 ident: bib0095 article-title: The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta publication-title: Nature – volume: 29 start-page: 3113 year: 2009 end-page: 3123 ident: bib0180 article-title: Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells publication-title: Mol. Cell. Biol. – volume: 310 start-page: 1821 year: 2005 end-page: 1824 ident: bib0210 article-title: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis publication-title: Science – volume: 44 start-page: 113 year: 2010 end-page: 139 ident: bib0290 article-title: Regulation of homologous recombination in eukaryotes publication-title: Annu. Rev. Genet. – volume: 7 start-page: 1551 year: 2008 end-page: 1562 ident: bib0215 article-title: Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line publication-title: DNA Repair (Amst) – volume: 105 start-page: 16248 year: 2008 end-page: 16253 ident: bib0140 article-title: Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 37 start-page: 5737 year: 2009 end-page: 5748 ident: bib0295 article-title: Repair of gaps opposite lesions by homologous recombination in mammalian cells publication-title: Nucleic Acids Res. – volume: 428 start-page: 97 year: 2004 end-page: 100 ident: bib0275 article-title: Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity publication-title: Nature – volume: 183 start-page: 1846 year: 2009 end-page: 1850 ident: bib0080 article-title: A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation publication-title: J. Immunol. – volume: 182 start-page: 6353 year: 2009 end-page: 6359 ident: bib0050 article-title: A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta publication-title: J. Immunol. – volume: 32 start-page: e157 year: 2004 ident: bib0220 article-title: A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA publication-title: Nucleic Acids Res. – volume: 425 start-page: 188 year: 2003 end-page: 191 ident: bib0110 article-title: Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation publication-title: Nature – volume: 66 start-page: 2363 year: 2009 end-page: 2381 ident: bib0195 article-title: Y-family DNA polymerases in mammalian cells publication-title: Cell. Mol. Life Sci. – volume: 28 start-page: 383 year: 2009 end-page: 393 ident: bib0270 article-title: Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals publication-title: EMBO J. – volume: 9 start-page: 135 year: 1998 end-page: 141 ident: bib0025 article-title: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting publication-title: Immunity – volume: 283 start-page: 1001 year: 1999 end-page: 1004 ident: bib0100 article-title: Efficient bypass of a thymine–thymine dimer by yeast DNA polymerase, Poleta publication-title: Science – volume: 105 start-page: 16125 year: 2008 end-page: 16130 ident: bib0120 article-title: Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 22 start-page: 233 year: 2001 end-page: 241 ident: bib0250 article-title: Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant publication-title: Carcinogenesis – volume: 16 start-page: 163 year: 2004 end-page: 171 ident: bib0015 article-title: Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation publication-title: Mol. Cell – volume: 5 start-page: 224 year: 2004 end-page: 229 ident: bib0045 article-title: Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice publication-title: Nat. Immunol. – volume: 225 start-page: 803 year: 1993 end-page: 823 ident: bib0155 article-title: Derivation of embryonic stem cell lines publication-title: Methods Enzymol. – volume: 204 start-page: 1989 year: 2007 end-page: 1998 ident: bib0135 article-title: A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification publication-title: J. Exp. Med. – volume: 276 start-page: 47759 year: 2001 end-page: 47762 ident: bib0225 article-title: Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress publication-title: J. Biol. Chem. – volume: 278 start-page: 11731 year: 2003 end-page: 11734 ident: bib0160 article-title: Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53 publication-title: J. Biol. Chem. – year: 2011 ident: bib0230 article-title: UV stalled replication forks restart by re-priming in human fibroblasts publication-title: Nucleic Acids Res. – volume: 6 start-page: 943 year: 2005 end-page: 953 ident: bib0090 article-title: Suffering in silence: the tolerance of DNA damage publication-title: Nat. Rev. Mol. Cell Biol. – volume: 19 start-page: 1690 year: 2010 end-page: 1701 ident: bib0235 article-title: ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells publication-title: Hum. Mol. Genet. – volume: 19 start-page: 5193 year: 2008 end-page: 5202 ident: bib0260 article-title: Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases publication-title: Mol. Biol. Cell – volume: 102 start-page: 8656 year: 2005 end-page: 8661 ident: bib0190 article-title: Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 43 start-page: 1587 year: 2006 end-page: 1594 ident: bib0075 article-title: The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40 publication-title: Mol. Immunol. – volume: 14 start-page: 491 year: 2004 end-page: 500 ident: bib0130 article-title: Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage publication-title: Mol. Cell – volume: 187 start-page: 1745 year: 1998 end-page: 1751 ident: bib0020 article-title: Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein publication-title: J. Exp. Med. – volume: 99 start-page: 233 year: 2002 end-page: 238 ident: bib0245 article-title: UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 23 start-page: 265 year: 2006 end-page: 271 ident: bib0175 article-title: REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo publication-title: Mol. Cell – volume: 203 start-page: 319 year: 2006 end-page: 323 ident: bib0070 article-title: Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice publication-title: J. Exp. Med. – volume: 2 start-page: 537 year: 2001 end-page: 541 ident: bib0055 article-title: DNA polymerase eta is an A–T mutator in somatic hypermutation of immunoglobulin variable genes publication-title: Nat. Immunol. – volume: 22 start-page: 6621 year: 2003 end-page: 6630 ident: bib0285 article-title: Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis publication-title: EMBO J. – volume: 204 start-page: 17 year: 2007 end-page: 23 ident: bib0085 article-title: DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse publication-title: J. Exp. Med. – volume: 30 start-page: 519 year: 2008 end-page: 529 ident: bib0145 article-title: PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40 publication-title: Mol. Cell – volume: 404 start-page: 34 year: 2010 end-page: 44 ident: bib0065 article-title: Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases alpha, delta, eta, iota, kappa, and REV1 publication-title: J. Mol. Biol. – volume: 4 start-page: e366 year: 2006 ident: bib0115 article-title: A role for PCNA ubiquitination in immunoglobulin hypermutation publication-title: PLoS Biol. – volume: 10 start-page: 327 year: 1991 end-page: 336 ident: bib0150 article-title: Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo publication-title: EMBO J. – volume: 25 start-page: 1913 year: 1997 end-page: 1919 ident: bib0300 article-title: Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice publication-title: Nucleic Acids Res. – volume: 76 start-page: 1 year: 2007 end-page: 22 ident: bib0005 article-title: Molecular mechanisms of antibody somatic hypermutation publication-title: Annu. Rev. Biochem. – volume: 36 start-page: 6767 year: 2008 end-page: 6780 ident: bib0280 article-title: REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo publication-title: Nucleic Acids Res. – volume: 77 start-page: 285 year: 2010 end-page: 293 ident: bib0240 article-title: Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication publication-title: Cytometry A – volume: 23 start-page: 959 year: 2002 end-page: 965 ident: bib0255 article-title: DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis publication-title: Carcinogenesis – volume: 204 start-page: 3209 year: 2007 end-page: 3219 ident: bib0010 article-title: Dependence of antibody gene diversification on uracil excision publication-title: J. Exp. Med. – volume: 8 start-page: 1444 year: 2009 end-page: 1451 ident: bib0185 article-title: Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions publication-title: DNA Repair (Amst) – volume: 191 start-page: 579 year: 2000 end-page: 584 ident: bib0030 article-title: Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern publication-title: J. Exp. Med. – volume: 201 start-page: 1191 year: 2005 end-page: 1196 ident: bib0040 article-title: Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse publication-title: J. Exp. Med. – volume: 283 start-page: 4658 year: 2008 end-page: 4664 ident: bib0170 article-title: Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance publication-title: J. Biol. Chem. – volume: 115 start-page: 4413 year: 2002 end-page: 4418 ident: bib0205 article-title: Localisation of human DNA polymerase kappa to replication foci publication-title: J. Cell Sci. – volume: 206 start-page: 2603 year: 2009 end-page: 2611 ident: bib0035 article-title: Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation publication-title: J. Exp. Med. – volume: 12 start-page: 1748 year: 2002 end-page: 1755 ident: bib0060 article-title: Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice publication-title: Curr. Biol. – volume: 39 start-page: 4575 year: 2000 end-page: 4580 ident: bib0265 article-title: Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta publication-title: Biochemistry – volume: 23 start-page: 3886 year: 2004 end-page: 3896 ident: bib0125 article-title: Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination publication-title: EMBO J. – volume: 15 start-page: 158 year: 2001 end-page: 172 ident: bib0200 article-title: Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells publication-title: Genes Dev. – volume: 419 start-page: 135 year: 2002 end-page: 141 ident: bib0105 article-title: RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO publication-title: Nature – volume: 225 start-page: 803 year: 1993 ident: 10.1016/j.dnarep.2011.08.005_bib0155 article-title: Derivation of embryonic stem cell lines publication-title: Methods Enzymol. doi: 10.1016/0076-6879(93)25052-4 – volume: 8 start-page: 1444 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0185 article-title: Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions publication-title: DNA Repair (Amst) doi: 10.1016/j.dnarep.2009.09.006 – volume: 187 start-page: 1745 year: 1998 ident: 10.1016/j.dnarep.2011.08.005_bib0020 article-title: Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein publication-title: J. Exp. Med. doi: 10.1084/jem.187.11.1745 – volume: 16 start-page: 163 year: 2004 ident: 10.1016/j.dnarep.2011.08.005_bib0015 article-title: Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation publication-title: Mol. Cell doi: 10.1016/j.molcel.2004.10.011 – volume: 105 start-page: 17724 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0165 article-title: Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0809844105 – volume: 283 start-page: 4658 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0170 article-title: Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance publication-title: J. Biol. Chem. doi: 10.1074/jbc.M709275200 – volume: 404 start-page: 34 year: 2010 ident: 10.1016/j.dnarep.2011.08.005_bib0065 article-title: Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases alpha, delta, eta, iota, kappa, and REV1 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2010.09.015 – volume: 419 start-page: 135 year: 2002 ident: 10.1016/j.dnarep.2011.08.005_bib0105 article-title: RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO publication-title: Nature doi: 10.1038/nature00991 – volume: 204 start-page: 3209 year: 2007 ident: 10.1016/j.dnarep.2011.08.005_bib0010 article-title: Dependence of antibody gene diversification on uracil excision publication-title: J. Exp. Med. doi: 10.1084/jem.20071768 – volume: 399 start-page: 700 year: 1999 ident: 10.1016/j.dnarep.2011.08.005_bib0095 article-title: The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta publication-title: Nature doi: 10.1038/21447 – volume: 10 start-page: 327 year: 1991 ident: 10.1016/j.dnarep.2011.08.005_bib0150 article-title: Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo publication-title: EMBO J. doi: 10.1002/j.1460-2075.1991.tb07953.x – volume: 7 start-page: 1551 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0215 article-title: Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line publication-title: DNA Repair (Amst) doi: 10.1016/j.dnarep.2008.05.012 – volume: 44 start-page: 113 year: 2010 ident: 10.1016/j.dnarep.2011.08.005_bib0290 article-title: Regulation of homologous recombination in eukaryotes publication-title: Annu. Rev. Genet. doi: 10.1146/annurev-genet-051710-150955 – volume: 22 start-page: 6621 year: 2003 ident: 10.1016/j.dnarep.2011.08.005_bib0285 article-title: Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis publication-title: EMBO J. doi: 10.1093/emboj/cdg626 – volume: 204 start-page: 17 year: 2007 ident: 10.1016/j.dnarep.2011.08.005_bib0085 article-title: DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse publication-title: J. Exp. Med. doi: 10.1084/jem.20062131 – year: 2011 ident: 10.1016/j.dnarep.2011.08.005_bib0230 article-title: UV stalled replication forks restart by re-priming in human fibroblasts publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr420 – volume: 5 start-page: 224 year: 2004 ident: 10.1016/j.dnarep.2011.08.005_bib0045 article-title: Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice publication-title: Nat. Immunol. doi: 10.1038/ni1031 – volume: 204 start-page: 1989 year: 2007 ident: 10.1016/j.dnarep.2011.08.005_bib0135 article-title: A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification publication-title: J. Exp. Med. doi: 10.1084/jem.20070902 – volume: 15 start-page: 158 year: 2001 ident: 10.1016/j.dnarep.2011.08.005_bib0200 article-title: Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells publication-title: Genes Dev. doi: 10.1101/gad.187501 – volume: 6 start-page: 943 year: 2005 ident: 10.1016/j.dnarep.2011.08.005_bib0090 article-title: Suffering in silence: the tolerance of DNA damage publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1781 – volume: 29 start-page: 3113 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0180 article-title: Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00071-09 – volume: 201 start-page: 1191 year: 2005 ident: 10.1016/j.dnarep.2011.08.005_bib0040 article-title: Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse publication-title: J. Exp. Med. doi: 10.1084/jem.20050292 – volume: 4 start-page: e366 year: 2006 ident: 10.1016/j.dnarep.2011.08.005_bib0115 article-title: A role for PCNA ubiquitination in immunoglobulin hypermutation publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0040366 – volume: 203 start-page: 319 year: 2006 ident: 10.1016/j.dnarep.2011.08.005_bib0070 article-title: Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice publication-title: J. Exp. Med. doi: 10.1084/jem.20052227 – volume: 23 start-page: 3886 year: 2004 ident: 10.1016/j.dnarep.2011.08.005_bib0125 article-title: Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination publication-title: EMBO J. doi: 10.1038/sj.emboj.7600383 – volume: 99 start-page: 233 year: 2002 ident: 10.1016/j.dnarep.2011.08.005_bib0245 article-title: UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.231611798 – volume: 183 start-page: 1846 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0080 article-title: A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation publication-title: J. Immunol. doi: 10.4049/jimmunol.0901240 – volume: 9 start-page: 135 year: 1998 ident: 10.1016/j.dnarep.2011.08.005_bib0025 article-title: Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting publication-title: Immunity doi: 10.1016/S1074-7613(00)80595-6 – volume: 102 start-page: 8656 year: 2005 ident: 10.1016/j.dnarep.2011.08.005_bib0190 article-title: Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0501852102 – volume: 2 start-page: 537 year: 2001 ident: 10.1016/j.dnarep.2011.08.005_bib0055 article-title: DNA polymerase eta is an A–T mutator in somatic hypermutation of immunoglobulin variable genes publication-title: Nat. Immunol. doi: 10.1038/88740 – volume: 206 start-page: 2603 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0035 article-title: Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation publication-title: J. Exp. Med. doi: 10.1084/jem.20091707 – volume: 22 start-page: 233 year: 2001 ident: 10.1016/j.dnarep.2011.08.005_bib0250 article-title: Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant publication-title: Carcinogenesis doi: 10.1093/carcin/22.2.233 – volume: 105 start-page: 16125 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0120 article-title: Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0802727105 – volume: 310 start-page: 1821 year: 2005 ident: 10.1016/j.dnarep.2011.08.005_bib0210 article-title: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis publication-title: Science doi: 10.1126/science.1120615 – volume: 36 start-page: 6767 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0280 article-title: REV1 restrains DNA polymerase zeta to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn651 – volume: 115 start-page: 4413 year: 2002 ident: 10.1016/j.dnarep.2011.08.005_bib0205 article-title: Localisation of human DNA polymerase kappa to replication foci publication-title: J. Cell Sci. doi: 10.1242/jcs.00162 – volume: 191 start-page: 579 year: 2000 ident: 10.1016/j.dnarep.2011.08.005_bib0030 article-title: Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern publication-title: J. Exp. Med. doi: 10.1084/jem.191.3.579 – volume: 276 start-page: 47759 year: 2001 ident: 10.1016/j.dnarep.2011.08.005_bib0225 article-title: Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress publication-title: J. Biol. Chem. doi: 10.1074/jbc.C100569200 – volume: 66 start-page: 2363 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0195 article-title: Y-family DNA polymerases in mammalian cells publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-009-0024-4 – volume: 12 start-page: 1748 year: 2002 ident: 10.1016/j.dnarep.2011.08.005_bib0060 article-title: Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice publication-title: Curr. Biol. doi: 10.1016/S0960-9822(02)01215-0 – volume: 37 start-page: 5737 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0295 article-title: Repair of gaps opposite lesions by homologous recombination in mammalian cells publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp632 – volume: 23 start-page: 265 year: 2006 ident: 10.1016/j.dnarep.2011.08.005_bib0175 article-title: REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.05.038 – volume: 278 start-page: 11731 year: 2003 ident: 10.1016/j.dnarep.2011.08.005_bib0160 article-title: Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53 publication-title: J. Biol. Chem. doi: 10.1074/jbc.C300023200 – volume: 25 start-page: 1913 year: 1997 ident: 10.1016/j.dnarep.2011.08.005_bib0300 article-title: Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice publication-title: Nucleic Acids Res. doi: 10.1093/nar/25.10.1913 – volume: 30 start-page: 519 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0145 article-title: PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40 publication-title: Mol. Cell doi: 10.1016/j.molcel.2008.03.024 – volume: 77 start-page: 285 year: 2010 ident: 10.1016/j.dnarep.2011.08.005_bib0240 article-title: Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication publication-title: Cytometry A doi: 10.1002/cyto.a.20839 – volume: 19 start-page: 1690 year: 2010 ident: 10.1016/j.dnarep.2011.08.005_bib0235 article-title: ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq046 – volume: 23 start-page: 959 year: 2002 ident: 10.1016/j.dnarep.2011.08.005_bib0255 article-title: DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis publication-title: Carcinogenesis doi: 10.1093/carcin/23.6.959 – volume: 14 start-page: 491 year: 2004 ident: 10.1016/j.dnarep.2011.08.005_bib0130 article-title: Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage publication-title: Mol. Cell doi: 10.1016/S1097-2765(04)00259-X – volume: 425 start-page: 188 year: 2003 ident: 10.1016/j.dnarep.2011.08.005_bib0110 article-title: Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation publication-title: Nature doi: 10.1038/nature01965 – volume: 28 start-page: 383 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0270 article-title: Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals publication-title: EMBO J. doi: 10.1038/emboj.2008.281 – volume: 32 start-page: e157 year: 2004 ident: 10.1016/j.dnarep.2011.08.005_bib0220 article-title: A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA publication-title: Nucleic Acids Res. doi: 10.1093/nar/gnh154 – volume: 39 start-page: 4575 year: 2000 ident: 10.1016/j.dnarep.2011.08.005_bib0265 article-title: Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta publication-title: Biochemistry doi: 10.1021/bi000130k – volume: 105 start-page: 16248 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0140 article-title: Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0808182105 – volume: 283 start-page: 1001 year: 1999 ident: 10.1016/j.dnarep.2011.08.005_bib0100 article-title: Efficient bypass of a thymine–thymine dimer by yeast DNA polymerase, Poleta publication-title: Science doi: 10.1126/science.283.5404.1001 – volume: 43 start-page: 1587 year: 2006 ident: 10.1016/j.dnarep.2011.08.005_bib0075 article-title: The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40 publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2005.09.017 – volume: 19 start-page: 5193 year: 2008 ident: 10.1016/j.dnarep.2011.08.005_bib0260 article-title: Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E08-07-0724 – volume: 428 start-page: 97 year: 2004 ident: 10.1016/j.dnarep.2011.08.005_bib0275 article-title: Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity publication-title: Nature doi: 10.1038/nature02352 – volume: 76 start-page: 1 year: 2007 ident: 10.1016/j.dnarep.2011.08.005_bib0005 article-title: Molecular mechanisms of antibody somatic hypermutation publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.76.061705.090740 – volume: 182 start-page: 6353 year: 2009 ident: 10.1016/j.dnarep.2011.08.005_bib0050 article-title: A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta publication-title: J. Immunol. doi: 10.4049/jimmunol.0900177
SSID	ssj0015766
Score	2.1825376
Snippet	► Polη can be activated dependent and independent of PCNA-Ub during both SHM and DDT. ► PCNA-Ub and Polη are necessary, but not essential, for efficient DDT of... The generation of high affinity antibodies in B cells critically depends on translesion synthesis (TLS) polymerases that introduce mutations into...
SourceID	proquest pubmed pascalfrancis crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	1051
SubjectTerms	Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Bacteriology Biological and medical sciences DNA Damage - genetics DNA damage tolerance DNA Repair - genetics DNA-Directed DNA Polymerase - metabolism Enzyme Activation Fundamental and applied biological sciences. Psychology Growth, nutrition, cell differenciation Lysine - genetics Mice Mice, Inbred C57BL Microbiology Molecular and cellular biology Molecular genetics Mutagenesis Mutagenesis. Repair Mutation PCNA Polη Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Somatic hypermutation Somatic Hypermutation, Immunoglobulin - genetics Translesion synthesis Ubiquitination Ultraviolet Rays
Title	PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance
URI	https://dx.doi.org/10.1016/j.dnarep.2011.08.005 https://www.ncbi.nlm.nih.gov/pubmed/21889916 https://www.proquest.com/docview/896240211 https://www.proquest.com/docview/902354783
Volume	10
WOSCitedRecordID	wos000296266900009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1568-7856 dateEnd: 20200831 omitProxy: false ssIdentifier: ssj0015766 issn: 1568-7864 databaseCode: AIEXJ dateStart: 20020122 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELbKLggkhGCXR3lUPgCXKlVeTexjWxUtqKz2sEBvkfMwpLRJN02r3T_FlX_Bb2Icx04XKMseuERW4rhx57Nnxv5mjNBLmrhx5CbUMGPHMVwvoga4EZbh2SZnLg15v0ql9HHiHx-T6ZSetFrfVCzMZu5nGTk_p8v_Kmq4B8IWobPXELduFG5AGYQOVxA7XP9J8Cej40F3HaZn67RM5VqfkerDbssqe8ZGG4rLfH4h1qVWYGuOxq-GvgpcXOUymesXcFSLxbomJVbEZWg_ZgtB9inzeVJo3NQ2rnhegJZLNe8XZpLZZ4mNig_cPepNeuqhCKCCD-sOE8naFlzF7qj3Xlf4lJYSs4mOKppU0crsa91iwbYXLyR7rqax1vOtRwyfyETmekI2t4Fnbk2vYAxaW6pa2IZ_VANyRWLWizMG_W0StZr9Ru2prf5ftKHmKCr62yyQrQSilUCc2SlS5u7bfp_CLLo_eDuevtP7VuC9VfFsqlsqWLNiFP7-NbuMobtLtoIhyuXZKrudn8oIOr2P7tXeCx5I1D1ArSQ7QIcDQFm-uMCvccUnrjZqDtCtoSrdHqlTBQ_RmYAn3g1P3MAT5xw38MQ_vmMJTVxDE1-CJgZoYoAeltDEGpoP0Yc349PRkVEf-2FEYNuXBhU-SUIZJWEE2oREnsVD7tohI7bLmelQ4obUjmwvBPuWh1EYcSiFzLHihPeJ8wjtZXmWPEGYx37l8fgc3H6XcUbMPtThPObcpR5vI0f9_0FU58QXR7PMg79Jv40M_dZS5oS5or6vRBvUdq20VwPA6xVvdi4hQf-c7Xqm41O7jbCCRgCCFJt9LEvy9Sog1BMbp5a1uwoVua5cnzht9FiiqmnfIkR4jk-v2dVn6E4zzJ-jvbJYJy_QzWhTpquig274U9Kpx8xPNMvz8A
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=PCNA+ubiquitination-independent+activation+of+polymerase+%CE%B7+during+somatic+hypermutation+and+DNA+damage+tolerance&rft.jtitle=DNA+repair&rft.au=Krijger%2C+Peter+H.L.&rft.au=van+den+Berk%2C+Paul+C.M.&rft.au=Wit%2C+Niek&rft.au=Langerak%2C+Petra&rft.date=2011-10-10&rft.issn=1568-7864&rft.volume=10&rft.issue=10&rft.spage=1051&rft.epage=1059&rft_id=info:doi/10.1016%2Fj.dnarep.2011.08.005&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_dnarep_2011_08_005
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1568-7864&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1568-7864&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1568-7864&client=summon