Learning a Generative Motion Model From Image Sequences Based on a Latent Motion Matrix

We propose to learn a probabilistic motion model from a sequence of images for spatio-temporal registration. Our model encodes motion in a low-dimensional probabilistic space - the motion matrix - which enables various motion analysis tasks such as simulation and interpolation of realistic motion pa...

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Veröffentlicht in:IEEE transactions on medical imaging Jg. 40; H. 5; S. 1405 - 1416
Hauptverfasser: Krebs, Julian, Delingette, Herve, Ayache, Nicholas, Mansi, Tommaso
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States IEEE 01.05.2021
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Institute of Electrical and Electronics Engineers
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ISSN:0278-0062, 1558-254X, 1558-254X
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Zusammenfassung:We propose to learn a probabilistic motion model from a sequence of images for spatio-temporal registration. Our model encodes motion in a low-dimensional probabilistic space - the motion matrix - which enables various motion analysis tasks such as simulation and interpolation of realistic motion patterns allowing for faster data acquisition and data augmentation. More precisely, the motion matrix allows to transport the recovered motion from one subject to another simulating for example a pathological motion in a healthy subject without the need for inter-subject registration. The method is based on a conditional latent variable model that is trained using amortized variational inference. This unsupervised generative model follows a novel multivariate Gaussian process prior and is applied within a temporal convolutional network which leads to a diffeomorphic motion model. Temporal consistency and generalizability is further improved by applying a temporal dropout training scheme. Applied to cardiac cine-MRI sequences, we show improved registration accuracy and spatio-temporally smoother deformations compared to three state-of-the-art registration algorithms. Besides, we demonstrate the model's applicability for motion analysis, simulation and super-resolution by an improved motion reconstruction from sequences with missing frames compared to linear and cubic interpolation.
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ISSN:0278-0062
1558-254X
1558-254X
DOI:10.1109/TMI.2021.3056531