Does Intravenous Lactated Ringer’s Solution Raise Serum Lactate?
Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate. We sought to determine if a bolus of 30 mL/kg of LR incre...
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| Vydané v: | The Journal of emergency medicine Ročník 55; číslo 3; s. 313 - 318 |
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| Hlavní autori: | , , , , |
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| Jazyk: | English |
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United States
Elsevier Inc
01.09.2018
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| ISSN: | 0736-4679, 2352-5029 |
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| Abstract | Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate.
We sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels.
In this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group.
After 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42–1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval −0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group.
In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR. |
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| AbstractList | Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate.
We sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels.
In this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group.
After 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42-1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval -0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group.
In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR. Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate. We sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels. In this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group. After 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42–1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval −0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group. In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR. Serum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate.BACKGROUNDSerum lactate increases in states of severe sepsis and shock, but its interpretation may be subject to confounders. Lactated Ringer's solution (LR) is used in the resuscitation of septic patients and contains 28 mmol/L of sodium lactate.We sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels.OBJECTIVESWe sought to determine if a bolus of 30 mL/kg of LR increases serum lactate levels.In this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group.METHODSIn this double-blind, randomized controlled trial, 30 volunteers were assigned to receive either 30 mL/kg of intravenous LR or normal saline (NS). Serum lactate was measured before and after the fluid bolus. The primary outcome was the difference in the change in lactate between the LR and NS groups. Secondarily, we assessed the change in pH, bicarbonate, sodium, and chloride in each group.After 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42-1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval -0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group.RESULTSAfter 30 mL/kg of intravenous LR, the mean serum lactate level increased by 0.93 mmol/L (95% confidence interval 0.42-1.44 mmol/L). However, there was also a small increase in the mean serum lactate level in the NS group of 0.37 mmol/L (95% confidence interval -0.26 mmol/L to 1.00 mmol/L), such that there was not a statistically significant difference in the change in lactate when comparing the LR group to the NS group (p = 0.2). The NS group saw larger declines in pH and bicarbonate and greater increases in chloride compared with the LR group.In healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR.CONCLUSIONIn healthy individuals, a modest but significant rise in mean serum lactate was seen after a 30 cc/kg LR bolus. There was no difference in mean serum lactate when comparing a 30 mL/kg bolus of NS to LR. |
| Author | Khan, Memona Patel, Jayme Skaggs, Zachary D. Zitek, Tony Rahbar, Aryan |
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| Cites_doi | 10.1056/NEJMoa1404380 10.1097/SLA.0b013e318295feba 10.1111/acem.12937 10.1056/NEJMoa010307 10.1056/NEJMoa1500896 10.1097/CCM.0000000000002365 10.1097/00000542-199905000-00007 10.1056/NEJMra1309483 10.1056/NEJMoa1401602 10.1007/s00134-014-3525-z 10.1056/NEJMoa1711584 10.1097/CCM.0b013e31827e83af 10.1097/00003246-199711000-00024 |
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| References | ARISE Investigators, Anzics Clinical Trials Group, Peake (bib4) 2014; 371 Young, Utter, Schermer (bib14) 2014; 259 Rivers, Nguyen, Havstad (bib1) 2001; 345 Dellinger, Levy, Rhodes (bib9) 2013; 41 Kraut, Madias (bib8) 2014; 371 Scheingraber, Rehm, Sehmisch (bib13) 1999; 90 Didwania, Miller, Kassel (bib10) 1997; 25 Mouncey, Osborn, Power (bib3) 2015; 372 ProCESS Investigators, Yealy, Kellum (bib2) 2014; 370 Emrath, Fortenberry, Travers (bib11) 2017; 45 Semler, Self, Wanderer (bib12) 2018; 378 Centers for Medicare & Medicaid Services (bib5) Zitek, Cleveland, Rahbar (bib7) 2016; 23 Cecconi, De Backer, Antonelli (bib6) 2014; 40 ARISE Investigators (10.1016/j.jemermed.2018.05.031_bib4) 2014; 371 Rivers (10.1016/j.jemermed.2018.05.031_bib1) 2001; 345 Centers for Medicare & Medicaid Services (10.1016/j.jemermed.2018.05.031_bib5) Kraut (10.1016/j.jemermed.2018.05.031_bib8) 2014; 371 ProCESS Investigators (10.1016/j.jemermed.2018.05.031_bib2) 2014; 370 Scheingraber (10.1016/j.jemermed.2018.05.031_bib13) 1999; 90 Didwania (10.1016/j.jemermed.2018.05.031_bib10) 1997; 25 Young (10.1016/j.jemermed.2018.05.031_bib14) 2014; 259 Mouncey (10.1016/j.jemermed.2018.05.031_bib3) 2015; 372 Dellinger (10.1016/j.jemermed.2018.05.031_bib9) 2013; 41 Cecconi (10.1016/j.jemermed.2018.05.031_bib6) 2014; 40 Semler (10.1016/j.jemermed.2018.05.031_bib12) 2018; 378 Zitek (10.1016/j.jemermed.2018.05.031_bib7) 2016; 23 Emrath (10.1016/j.jemermed.2018.05.031_bib11) 2017; 45 |
| References_xml | – ident: bib5 article-title: CMS specifications manual version 5.2a – volume: 371 start-page: 2309 year: 2014 end-page: 2319 ident: bib8 article-title: Lactic acidosis publication-title: N Engl J Med – volume: 259 start-page: 255 year: 2014 end-page: 262 ident: bib14 article-title: Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial publication-title: Ann Surg – volume: 345 start-page: 1368 year: 2001 end-page: 1377 ident: bib1 article-title: Early goal-directed therapy in the treatment of severe sepsis and septic shock publication-title: N Engl J Med – volume: 372 start-page: 1301 year: 2015 end-page: 1311 ident: bib3 article-title: Trial of early, goal-directed resuscitation for septic shock publication-title: N Engl J Med – volume: 25 start-page: 1851 year: 1997 end-page: 1854 ident: bib10 article-title: Effect of intravenous lactated Ringer’s solution infusion on the circulating lactate concentration: part 3. Results of a prospective, randomized, double-blind, placebo-controlled trial publication-title: Crit Care Med – volume: 378 start-page: 829 year: 2018 end-page: 839 ident: bib12 article-title: Balanced crystalloids versus saline in critically ill adults publication-title: N Engl J Med – volume: 40 start-page: 1795 year: 2014 end-page: 1815 ident: bib6 article-title: Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine publication-title: Intensive Care Med – volume: 370 start-page: 1683 year: 2014 end-page: 1693 ident: bib2 article-title: A randomized trial of protocol-based care for early septic shock publication-title: N Engl J Med – volume: 45 start-page: 1177 year: 2017 end-page: 1183 ident: bib11 article-title: Resuscitation with balanced fluids is associated with improved survival in pediatric severe sepsis publication-title: Crit Care Med – volume: 371 start-page: 1496 year: 2014 end-page: 1506 ident: bib4 article-title: Goal-directed resuscitation for patients with early septic shock publication-title: N Engl J Med – volume: 23 start-page: 718 year: 2016 end-page: 721 ident: bib7 article-title: Effect of nebulized albuterol on serum lactate and potassium in healthy subjects publication-title: Acad Emerg Med – volume: 41 start-page: 580 year: 2013 end-page: 637 ident: bib9 article-title: Surviving Sepsis Campaign: international guidelines for the management of severe sepsis and septic shock 2012 publication-title: Crit Care Med – volume: 90 start-page: 1265 year: 1999 end-page: 1270 ident: bib13 article-title: Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery publication-title: Anesthesiology – volume: 371 start-page: 1496 year: 2014 ident: 10.1016/j.jemermed.2018.05.031_bib4 article-title: Goal-directed resuscitation for patients with early septic shock publication-title: N Engl J Med doi: 10.1056/NEJMoa1404380 – volume: 259 start-page: 255 year: 2014 ident: 10.1016/j.jemermed.2018.05.031_bib14 article-title: Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial publication-title: Ann Surg doi: 10.1097/SLA.0b013e318295feba – volume: 23 start-page: 718 year: 2016 ident: 10.1016/j.jemermed.2018.05.031_bib7 article-title: Effect of nebulized albuterol on serum lactate and potassium in healthy subjects publication-title: Acad Emerg Med doi: 10.1111/acem.12937 – volume: 345 start-page: 1368 year: 2001 ident: 10.1016/j.jemermed.2018.05.031_bib1 article-title: Early goal-directed therapy in the treatment of severe sepsis and septic shock publication-title: N Engl J Med doi: 10.1056/NEJMoa010307 – volume: 372 start-page: 1301 year: 2015 ident: 10.1016/j.jemermed.2018.05.031_bib3 article-title: Trial of early, goal-directed resuscitation for septic shock publication-title: N Engl J Med doi: 10.1056/NEJMoa1500896 – volume: 45 start-page: 1177 year: 2017 ident: 10.1016/j.jemermed.2018.05.031_bib11 article-title: Resuscitation with balanced fluids is associated with improved survival in pediatric severe sepsis publication-title: Crit Care Med doi: 10.1097/CCM.0000000000002365 – ident: 10.1016/j.jemermed.2018.05.031_bib5 – volume: 90 start-page: 1265 year: 1999 ident: 10.1016/j.jemermed.2018.05.031_bib13 article-title: Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery publication-title: Anesthesiology doi: 10.1097/00000542-199905000-00007 – volume: 371 start-page: 2309 year: 2014 ident: 10.1016/j.jemermed.2018.05.031_bib8 article-title: Lactic acidosis publication-title: N Engl J Med doi: 10.1056/NEJMra1309483 – volume: 370 start-page: 1683 year: 2014 ident: 10.1016/j.jemermed.2018.05.031_bib2 article-title: A randomized trial of protocol-based care for early septic shock publication-title: N Engl J Med doi: 10.1056/NEJMoa1401602 – volume: 40 start-page: 1795 year: 2014 ident: 10.1016/j.jemermed.2018.05.031_bib6 article-title: Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine publication-title: Intensive Care Med doi: 10.1007/s00134-014-3525-z – volume: 378 start-page: 829 year: 2018 ident: 10.1016/j.jemermed.2018.05.031_bib12 article-title: Balanced crystalloids versus saline in critically ill adults publication-title: N Engl J Med doi: 10.1056/NEJMoa1711584 – volume: 41 start-page: 580 year: 2013 ident: 10.1016/j.jemermed.2018.05.031_bib9 article-title: Surviving Sepsis Campaign: international guidelines for the management of severe sepsis and septic shock 2012 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e31827e83af – volume: 25 start-page: 1851 year: 1997 ident: 10.1016/j.jemermed.2018.05.031_bib10 article-title: Effect of intravenous lactated Ringer’s solution infusion on the circulating lactate concentration: part 3. Results of a prospective, randomized, double-blind, placebo-controlled trial publication-title: Crit Care Med doi: 10.1097/00003246-199711000-00024 |
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| SubjectTerms | Administration, Intravenous Adult Double-Blind Method Female Healthy Volunteers Humans isotonic fluids lactate lactated Ringer's Lactates - blood Male resuscitation Ringer's Lactate - administration & dosage sepsis Sodium Chloride - administration & dosage |
| Title | Does Intravenous Lactated Ringer’s Solution Raise Serum Lactate? |
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