Influence of citalopram and environmental temperature on exercise-induced changes in BDNF

► Acute exercise increases serum BDNF and cortisol. ► Lower serum BDNF levels are found with acute citalopram administration. ► Circulating BDNF was higher with exercise in 30 °C, which raised core temperature. Purpose: Serum brain-derived neurotrophic factor (BDNF) is known to increase with exercis...

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Vydané v:	Neuroscience letters Ročník 494; číslo 2; s. 150 - 154
Hlavní autori:	Goekint, Maaike, Roelands, Bart, Heyman, Elsa, Njemini, Rose, Meeusen, Romain
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Shannon Elsevier Ireland Ltd 25.04.2011 Elsevier
Predmet:	Acute exercise Biological and medical sciences Blood Blood-brain barrier Brain Brain - drug effects Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood citalopram Citalopram - pharmacology Cross-Over Studies Double-Blind Method Exercise Exercise - physiology Exercise Test Fundamental and applied biological sciences. Psychology Heart rate Heat Hormones Hot Temperature Humans Hydrocortisone Hydrocortisone - blood Male Membrane permeability monoamines Nervous system Physical training Professional sports Selective serotonin reuptake inhibitor Serotonin uptake inhibitors Serotonin Uptake Inhibitors - pharmacology SSRI Stimuli Temperature effects Vertebrates: nervous system and sense organs SSRI Acute exercise Brain-derived neurotrophic factor Humans Selective serotonin reuptake inhibitor Physical exercise Human Temperature Serotonin Acute Reuptake inhibitor Citalopram Neurotransmitter Brain derived neurotrophic factor
ISSN:	0304-3940, 1872-7972, 1872-7972
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Shrnutí:	► Acute exercise increases serum BDNF and cortisol. ► Lower serum BDNF levels are found with acute citalopram administration. ► Circulating BDNF was higher with exercise in 30 °C, which raised core temperature. Purpose: Serum brain-derived neurotrophic factor (BDNF) is known to increase with exercise. This increase is believed to originate from the brain and it is suggested that monoamines are involved in BDNF regulation. Heat exposure could influence the supposed BDNF output from the brain. Therefore, we hypothesized that administration of a selective serotonin reuptake inhibitor could influence the exercise-induced increase in BDNF, and that peripheral BDNF will be higher when exercise is performed in the heat. Methods: Eleven well-trained males performed 4 experimental trials on a cycle ergometer with citalopram or placebo treatment (20 mg in 12 h) in an environmental temperature of 18 °C or 30 °C. Blood samples (BDNF and cortisol) were taken at 4 time points: at rest, after 60 min at 55% W max, after a time trial of 30 min at 75% W max and following 15 min of recovery. Heart rate and core temperature were measured. Results: Performance on the time trial was 20% worse in 30 °C compared to 18 °C ( p < 0.01), without influence of citalopram. Serum BDNF was found to be lower under citalopram treatment, while basal cortisol levels were increased ( p < 0.05). Exercise triggered an increase in both BDNF and cortisol ( p < 0.001). BDNF followed the same pattern as core temperature during exercise, with higher levels of both variables in 30 °C. Cortisol was also increased in 30 °C compared to temperate conditions ( p < 0.01). Conclusion: Exercise caused a rise in serum BDNF and cortisol. This increase was enhanced with exercise in the heat. Since permeability of the blood–brain barrier increases with exercise in the heat, the hypothesis was raised that this causes a higher cerebral output of BDNF. Serotonergic stimulation did not increase peripheral BDNF, which was even lower with citalopram administration. Future research should focus on mechanisms behind BDNF increase with exercise.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0304-3940 1872-7972 1872-7972
DOI:	10.1016/j.neulet.2011.03.001