Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases

Reactive oxygen species (ROS), often also referred to as free radicals, play an important role in aging. It is widely assumed that mitochondria are the predominant source of ROS relevant for the aging process. In this hypothesis article, we suggest that the role of ROS generated by NOX family NADPH...

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Vydané v:Experimental gerontology Ročník 42; číslo 4; s. 256 - 262
Hlavný autor: Krause, Karl-Heinz
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Inc 01.04.2007
Predmet:
Aging - metabolism
Aging NOX Gerontology
Cardiovascular Diseases - metabolism
Cataract - metabolism
Humans
Mitochondria - metabolism
NADPH Oxidases - metabolism
Neurodegenerative Diseases - metabolism
Osteoporosis - metabolism
Presbycusis - metabolism
Reactive Oxygen Species - metabolism
Stroke - metabolism
Aging NOX Gerontology
ISSN:0531-5565, 1873-6815
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Shrnutí:Reactive oxygen species (ROS), often also referred to as free radicals, play an important role in aging. It is widely assumed that mitochondria are the predominant source of ROS relevant for the aging process. In this hypothesis article, we suggest that the role of ROS generated by NOX family NADPH oxidases has been largely overlooked in aging theories. NOX NADPH oxidases form a seven member gene family and are high level ROS-generating enzymes. As opposed to mitochondria, which generate ROS as a byproduct of their metabolism, NOX enzymes are professional ROS generators. From an experimental point of view, there is now abundant evidence for the involvement of NOX enzymes in age-associated diseases. The role of NOX enzymes in the aging process itself and their relative contribution as compared to mitochondria needs further investigations.
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ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2006.10.011