Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients: A Randomized Trial

The duration of antibiotic therapy in critically ill patients with sepsis can result in antibiotic overuse, increasing the risk of developing bacterial resistance. To test the hypothesis that an algorithm based on serial measurements of procalcitonin (PCT) allows reduction in the duration of antibio...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 177; no. 5; pp. 498 - 505
Main Authors:	Nobre, Vandack, Harbarth, Stephan, Graf, Jean-Daniel, Rohner, Peter, Pugin, Jerome
Format:	Journal Article
Language:	English
Published:	New York, NY Am Thoracic Soc 01.03.2008 American Lung Association American Thoracic Society
Subjects:	Aged Aged, 80 and over Algorithms Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - administration & dosage Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents Bacterial infections Biological and medical sciences Biomarkers Calcitonin - blood Calcitonin Gene-Related Peptide Clinical Protocols Critical Illness Female Glycoproteins - blood Humans Infections Intensive care Intensive care medicine Kaplan-Meier Estimate Length of Stay Male Medical sciences Middle Aged Patients Pharmacology. Drug treatments Pneumonia Protein Precursors - blood Recurrence Sepsis Sepsis - blood Sepsis - drug therapy Sepsis - mortality Shock, Septic - blood Shock, Septic - drug therapy Shock, Septic - mortality Human Infection Sepsis syndrome Antibiotic Intensive care Treatment controlled trial Procalcitonin antibiotics Resuscitation sepsis
ISSN:	1073-449X, 1535-4970, 1535-4970
Online Access:	Get full text
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