Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: Evidence in optical coherence tomography

Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the...

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Vydané v:	Neuroscience letters Ročník 480; číslo 1; s. 69 - 72
Hlavní autori:	Lu, Yan, Li, Zhen, Zhang, Xinqing, Ming, Baoquan, Jia, Jianping, Wang, Rong, Ma, Daqing
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Shannon Elsevier Ireland Ltd 09.08.2010 Elsevier
Predmet:	Aged Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Nerve Fibers - pathology Neurology Optical coherence tomography Retina - pathology Retinal nerve fiber layer Tomography, Optical Coherence Vertebrates: nervous system and sense organs Optical coherence tomography Alzheimer's disease Retinal nerve fiber layer Nervous system diseases Alzheimer disease Retina Cerebral disorder Eye Visual system Central nervous system disease Early Degenerative disease Nerve fiber
ISSN:	0304-3940, 1872-7972, 1872-7972
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Abstract	Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner ( p < 0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant.
AbstractList	Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner (p<0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant. Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner (p<0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant.Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner (p<0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant. Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner ( p < 0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant.
Author	Li, Zhen Ma, Daqing Lu, Yan Wang, Rong Ming, Baoquan Jia, Jianping Zhang, Xinqing
Author_xml	– sequence: 1 givenname: Yan surname: Lu fullname: Lu, Yan email: louiseluyan@yahoo.com.cn organization: Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China – sequence: 2 givenname: Zhen surname: Li fullname: Li, Zhen organization: Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China – sequence: 3 givenname: Xinqing surname: Zhang fullname: Zhang, Xinqing organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China – sequence: 4 givenname: Baoquan surname: Ming fullname: Ming, Baoquan organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China – sequence: 5 givenname: Jianping surname: Jia fullname: Jia, Jianping organization: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China – sequence: 6 givenname: Rong surname: Wang fullname: Wang, Rong organization: Center laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China – sequence: 7 givenname: Daqing surname: Ma fullname: Ma, Daqing organization: Anaesthetics, Pain Medicine & Intensive Care, Department of Surgery & Cancer, Imperial College London, Chelsea and Westminster Hospital, SW10 9NH London, United Kingdom
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Cites_doi	10.1212/01.wnl.0000244490.07925.8b 10.1016/S1388-2457(01)00620-4 10.1093/brain/107.1.309 10.1056/NEJM198608213150804 10.1016/j.jns.2006.02.009 10.1023/A:1022949121078 10.1016/S0197-4580(01)00234-2 10.1212/WNL.34.7.939 10.1001/archneur.1985.04060070057015 10.1111/j.1600-0420.1996.tb00090.x 10.1002/ana.410260207 10.1167/iovs.06-1029 10.1159/000058350 10.1002/ana.410330305 10.1001/archopht.1991.01080020045040 10.1159/000051281 10.1136/bjo.79.6.596 10.1002/ana.410260208 10.1016/S0161-6420(90)32621-0 10.1016/S0002-9394(14)74985-2 10.1034/j.1600-0420.2001.079002187.x 10.1097/01.wno.0000204645.56873.26
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Keywords	Optical coherence tomography Alzheimer's disease Retinal nerve fiber layer Nervous system diseases Alzheimer disease Retina Cerebral disorder Eye Visual system Central nervous system disease Early Degenerative disease Nerve fiber
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References	(bib6) 1994 Davies, McCoubrie, McDonald, Jobst (bib5) 1995; 79 Kergoat, Kergoat, Justino, Chertkow, Robillard, Bergman (bib13) 2002; 48 Danesh-Meyer, Birch, Ku, Carroll, Gamble (bib4) 2006; 67 Parisi, Restuccia, Fattapposta, Mina, Bucci, Pierelli (bib18) 2001; 112 Iseri, Altinaş, Tokay, Yüksel (bib9) 2006; 26 McKhann, Drachman, Folstein, Katzman, Price, Stadlan (bib16) 1984; 34 Janciauskiene, Krakau (bib10) 2003; 106 Kergoat, Kergoat, Justino, Chertkow, Robillard, Bergman (bib14) 2001; 79 Curcio, Drucker (bib3) 1993; 33 Justino, Kergoat, Bergman, Chertkow, Robillard, Kergoat (bib11) 2001; 22 Tsai, Ritch, Schwartz, Lee, Miller, Chi, Hsieh (bib23) 1991; 109 Berisha, Feke, Trempe, McMeel, Schepens (bib1) 2007; 48 Kergoat, Kergoat, Justino, Robillard, Bergman, Chertkow (bib15) 2001; 12 Ziangirova, Antonova (bib24) 2003; 2 Schlotterer, Moscovitch, Crapper-McLachlan (bib20) 1984; 107 Trick, Barris, Bickler-Bluth (bib22) 1989; 26 Hinton, Sadun, Blanks, Miller (bib8) 1986; 315 Tamura, Kawakami, Kanamoto, Kato, Yokoyama, Sasaki, Izumi, Matsumoto, Mishima (bib21) 2006; 246 Cogan (bib2) 1995; 100 Katz, Rimmer, Iragui, Katzman (bib12) 1989; 26 Sadun, Bassi (bib19) 1990; 97 Hedges, Perez Galves, Speigelman, Barbas, Peli, Yardley (bib7) 1996; 74 Nissen, Corkin, Buonanno, Growdon, Wray, Bauer (bib17) 1985; 42 Katz (10.1016/j.neulet.2010.06.006_bib12) 1989; 26 Nissen (10.1016/j.neulet.2010.06.006_bib17) 1985; 42 Berisha (10.1016/j.neulet.2010.06.006_bib1) 2007; 48 Kergoat (10.1016/j.neulet.2010.06.006_bib13) 2002; 48 Curcio (10.1016/j.neulet.2010.06.006_bib3) 1993; 33 Danesh-Meyer (10.1016/j.neulet.2010.06.006_bib4) 2006; 67 Janciauskiene (10.1016/j.neulet.2010.06.006_bib10) 2003; 106 Kergoat (10.1016/j.neulet.2010.06.006_bib15) 2001; 12 Hinton (10.1016/j.neulet.2010.06.006_bib8) 1986; 315 Iseri (10.1016/j.neulet.2010.06.006_bib9) 2006; 26 McKhann (10.1016/j.neulet.2010.06.006_bib16) 1984; 34 Sadun (10.1016/j.neulet.2010.06.006_bib19) 1990; 97 Parisi (10.1016/j.neulet.2010.06.006_bib18) 2001; 112 Ziangirova (10.1016/j.neulet.2010.06.006_bib24) 2003; 2 Schlotterer (10.1016/j.neulet.2010.06.006_bib20) 1984; 107 Cogan (10.1016/j.neulet.2010.06.006_bib2) 1995; 100 (10.1016/j.neulet.2010.06.006_bib6) 1994 Hedges (10.1016/j.neulet.2010.06.006_bib7) 1996; 74 Trick (10.1016/j.neulet.2010.06.006_bib22) 1989; 26 Tsai (10.1016/j.neulet.2010.06.006_bib23) 1991; 109 Justino (10.1016/j.neulet.2010.06.006_bib11) 2001; 22 Davies (10.1016/j.neulet.2010.06.006_bib5) 1995; 79 Tamura (10.1016/j.neulet.2010.06.006_bib21) 2006; 246 Kergoat (10.1016/j.neulet.2010.06.006_bib14) 2001; 79
References_xml	– volume: 33 start-page: 248 year: 1993 end-page: 257 ident: bib3 article-title: Retinal ganglion cells in Alzheimer's disease and aging publication-title: Ann. Neurol. – volume: 74 start-page: 271 year: 1996 end-page: 275 ident: bib7 article-title: Retinal nerve fiber layer abnormalities in Alzheimer's disease publication-title: Acta Ophthalmol. Scand. – volume: 97 start-page: 9 year: 1990 end-page: 17 ident: bib19 article-title: Optic nerve damage in Alzheimer's disease publication-title: Ophthalmology – year: 1994 ident: bib6 article-title: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) – volume: 112 start-page: 1860 year: 2001 end-page: 1867 ident: bib18 article-title: Morphological and functional retinal impairment in Alzheimer's disease patients publication-title: Clin. Neurophysiol. – volume: 315 start-page: 485 year: 1986 end-page: 487 ident: bib8 article-title: Optic-nerve degeneration in Alzheimer's disease publication-title: N. Engl. J. Med. – volume: 246 start-page: 79 year: 2006 end-page: 83 ident: bib21 article-title: High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease publication-title: J. Neurol. Sci. – volume: 26 start-page: 18 year: 2006 end-page: 24 ident: bib9 article-title: Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease publication-title: J. Neuroophthalmol. – volume: 79 start-page: 596 year: 1995 end-page: 600 ident: bib5 article-title: Myelinated axon number in the optic nerve is unaffected by Alzheimer's disease publication-title: Br. J. Ophthalmol. – volume: 42 start-page: 667 year: 1985 end-page: 671 ident: bib17 article-title: Spatial vision in Alzheimer's disease. General findings and a case report publication-title: Arch. Neurol. – volume: 26 start-page: 221 year: 1989 end-page: 225 ident: bib12 article-title: Abnormal pattern electroretinogram in Alzheimer's disease: evidence for retinal ganglion cell degeneration? publication-title: Ann. Neurol. – volume: 106 start-page: 215 year: 2003 end-page: 223 ident: bib10 article-title: Alzheimer's peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome publication-title: Doc. Ophthalmol. – volume: 79 start-page: 187 year: 2001 end-page: 191 ident: bib14 article-title: An evaluation of the retinal nerve fiber layer thickness by scanning laser polarimetry in individuals with dementia of the Alzheimer type publication-title: Acta Ophthalmol. Scand. – volume: 2 start-page: 40 year: 2003 end-page: 43 ident: bib24 article-title: Local senile ocular amyloidosis in the pathogenesis of open-angle glaucoma and pseudo-exfoliative syndrome publication-title: Vestn. Ross. Akad. Med. Nauk. – volume: 100 start-page: 68 year: 1995 end-page: 72 ident: bib2 article-title: Visual disturbances with focal progressive dementing disease publication-title: Am. J. Ophthalmol. – volume: 12 start-page: 359 year: 2001 end-page: 363 ident: bib15 article-title: Normal optic nerve head topography in the early stages of dementia of the Alzheimer type publication-title: Dement. Geriatr. Cogn. Disord. – volume: 48 start-page: 197 year: 2002 end-page: 203 ident: bib13 article-title: Visual retinocortical function in dementia of the Alzheimer type publication-title: Gerontology – volume: 67 start-page: 1852 year: 2006 end-page: 1854 ident: bib4 article-title: Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging publication-title: Neurology – volume: 22 start-page: 691 year: 2001 end-page: 695 ident: bib11 article-title: Neuroretinal function is normal in early dementia of the Alzheimer type publication-title: Neurobiol. Agin. – volume: 34 start-page: 939 year: 1984 end-page: 944 ident: bib16 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease publication-title: Neurology – volume: 109 start-page: 199 year: 1991 end-page: 204 ident: bib23 article-title: Optic nerve head and nerve fiber layer in Alzheimer's disease publication-title: Arch. Ophthalmol. – volume: 48 start-page: 2285 year: 2007 end-page: 2289 ident: bib1 article-title: Retinal abnormalities in early Alzheimer's disease publication-title: Invest. Ophthalmol. Vis. Sci. – volume: 26 start-page: 226 year: 1989 end-page: 231 ident: bib22 article-title: Abnormal pattern electroretinograms in patients with senile dementia of the Alzheimer type publication-title: Ann. Neurol. – volume: 107 start-page: 309 year: 1984 end-page: 325 ident: bib20 article-title: Visual processing deficits as assessed by spatial frequency contrast sensitivity and backward masking in normal ageing and Alzheimer's disease publication-title: Brain – volume: 67 start-page: 1852 year: 2006 ident: 10.1016/j.neulet.2010.06.006_bib4 article-title: Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging publication-title: Neurology doi: 10.1212/01.wnl.0000244490.07925.8b – volume: 112 start-page: 1860 year: 2001 ident: 10.1016/j.neulet.2010.06.006_bib18 article-title: Morphological and functional retinal impairment in Alzheimer's disease patients publication-title: Clin. Neurophysiol. doi: 10.1016/S1388-2457(01)00620-4 – volume: 107 start-page: 309 year: 1984 ident: 10.1016/j.neulet.2010.06.006_bib20 article-title: Visual processing deficits as assessed by spatial frequency contrast sensitivity and backward masking in normal ageing and Alzheimer's disease publication-title: Brain doi: 10.1093/brain/107.1.309 – volume: 315 start-page: 485 year: 1986 ident: 10.1016/j.neulet.2010.06.006_bib8 article-title: Optic-nerve degeneration in Alzheimer's disease publication-title: N. Engl. J. Med. doi: 10.1056/NEJM198608213150804 – volume: 246 start-page: 79 year: 2006 ident: 10.1016/j.neulet.2010.06.006_bib21 article-title: High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2006.02.009 – volume: 106 start-page: 215 year: 2003 ident: 10.1016/j.neulet.2010.06.006_bib10 article-title: Alzheimer's peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome publication-title: Doc. Ophthalmol. doi: 10.1023/A:1022949121078 – volume: 22 start-page: 691 year: 2001 ident: 10.1016/j.neulet.2010.06.006_bib11 article-title: Neuroretinal function is normal in early dementia of the Alzheimer type publication-title: Neurobiol. Agin. doi: 10.1016/S0197-4580(01)00234-2 – volume: 34 start-page: 939 year: 1984 ident: 10.1016/j.neulet.2010.06.006_bib16 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease publication-title: Neurology doi: 10.1212/WNL.34.7.939 – volume: 42 start-page: 667 year: 1985 ident: 10.1016/j.neulet.2010.06.006_bib17 article-title: Spatial vision in Alzheimer's disease. General findings and a case report publication-title: Arch. Neurol. doi: 10.1001/archneur.1985.04060070057015 – volume: 74 start-page: 271 year: 1996 ident: 10.1016/j.neulet.2010.06.006_bib7 article-title: Retinal nerve fiber layer abnormalities in Alzheimer's disease publication-title: Acta Ophthalmol. Scand. doi: 10.1111/j.1600-0420.1996.tb00090.x – volume: 2 start-page: 40 year: 2003 ident: 10.1016/j.neulet.2010.06.006_bib24 article-title: Local senile ocular amyloidosis in the pathogenesis of open-angle glaucoma and pseudo-exfoliative syndrome publication-title: Vestn. Ross. Akad. Med. Nauk. – volume: 26 start-page: 221 year: 1989 ident: 10.1016/j.neulet.2010.06.006_bib12 article-title: Abnormal pattern electroretinogram in Alzheimer's disease: evidence for retinal ganglion cell degeneration? publication-title: Ann. Neurol. doi: 10.1002/ana.410260207 – volume: 48 start-page: 2285 year: 2007 ident: 10.1016/j.neulet.2010.06.006_bib1 article-title: Retinal abnormalities in early Alzheimer's disease publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.06-1029 – year: 1994 ident: 10.1016/j.neulet.2010.06.006_bib6 – volume: 48 start-page: 197 year: 2002 ident: 10.1016/j.neulet.2010.06.006_bib13 article-title: Visual retinocortical function in dementia of the Alzheimer type publication-title: Gerontology doi: 10.1159/000058350 – volume: 33 start-page: 248 year: 1993 ident: 10.1016/j.neulet.2010.06.006_bib3 article-title: Retinal ganglion cells in Alzheimer's disease and aging publication-title: Ann. Neurol. doi: 10.1002/ana.410330305 – volume: 109 start-page: 199 year: 1991 ident: 10.1016/j.neulet.2010.06.006_bib23 article-title: Optic nerve head and nerve fiber layer in Alzheimer's disease publication-title: Arch. Ophthalmol. doi: 10.1001/archopht.1991.01080020045040 – volume: 12 start-page: 359 year: 2001 ident: 10.1016/j.neulet.2010.06.006_bib15 article-title: Normal optic nerve head topography in the early stages of dementia of the Alzheimer type publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000051281 – volume: 79 start-page: 596 year: 1995 ident: 10.1016/j.neulet.2010.06.006_bib5 article-title: Myelinated axon number in the optic nerve is unaffected by Alzheimer's disease publication-title: Br. J. Ophthalmol. doi: 10.1136/bjo.79.6.596 – volume: 26 start-page: 226 year: 1989 ident: 10.1016/j.neulet.2010.06.006_bib22 article-title: Abnormal pattern electroretinograms in patients with senile dementia of the Alzheimer type publication-title: Ann. Neurol. doi: 10.1002/ana.410260208 – volume: 97 start-page: 9 year: 1990 ident: 10.1016/j.neulet.2010.06.006_bib19 article-title: Optic nerve damage in Alzheimer's disease publication-title: Ophthalmology doi: 10.1016/S0161-6420(90)32621-0 – volume: 100 start-page: 68 year: 1995 ident: 10.1016/j.neulet.2010.06.006_bib2 article-title: Visual disturbances with focal progressive dementing disease publication-title: Am. J. Ophthalmol. doi: 10.1016/S0002-9394(14)74985-2 – volume: 79 start-page: 187 year: 2001 ident: 10.1016/j.neulet.2010.06.006_bib14 article-title: An evaluation of the retinal nerve fiber layer thickness by scanning laser polarimetry in individuals with dementia of the Alzheimer type publication-title: Acta Ophthalmol. Scand. doi: 10.1034/j.1600-0420.2001.079002187.x – volume: 26 start-page: 18 year: 2006 ident: 10.1016/j.neulet.2010.06.006_bib9 article-title: Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease publication-title: J. Neuroophthalmol. doi: 10.1097/01.wno.0000204645.56873.26
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Snippet	Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to...
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SubjectTerms	Aged Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Nerve Fibers - pathology Neurology Optical coherence tomography Retina - pathology Retinal nerve fiber layer Tomography, Optical Coherence Vertebrates: nervous system and sense organs
Title	Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: Evidence in optical coherence tomography
URI	https://dx.doi.org/10.1016/j.neulet.2010.06.006 https://www.ncbi.nlm.nih.gov/pubmed/20609426 https://www.proquest.com/docview/733981756 https://www.proquest.com/docview/856778097
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