Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: Evidence in optical coherence tomography

Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the...

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Bibliographic Details
Published in:Neuroscience letters Vol. 480; no. 1; pp. 69 - 72
Main Authors: Lu, Yan, Li, Zhen, Zhang, Xinqing, Ming, Baoquan, Jia, Jianping, Wang, Rong, Ma, Daqing
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 09.08.2010
Elsevier
Subjects:
Aged
Alzheimer Disease - pathology
Alzheimer's disease
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Eye and associated structures. Visual pathways and centers. Vision
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Nerve Fibers - pathology
Neurology
Optical coherence tomography
Retina - pathology
Retinal nerve fiber layer
Tomography, Optical Coherence
Vertebrates: nervous system and sense organs
Optical coherence tomography
Alzheimer's disease
Retinal nerve fiber layer
Nervous system diseases
Alzheimer disease
Retina
Cerebral disorder
Eye
Visual system
Central nervous system disease
Early
Degenerative disease
Nerve fiber
ISSN:0304-3940, 1872-7972, 1872-7972
Online Access:Get full text
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Description
Summary:Alzheimer's disease (AD) patients often have visual disorders which may be due to retinal nerve degenerative changes. The aim of the current study was to determine the thickness changes of retina nerve fibers with optical coherence tomography (OCT) in AD patients. The OCT was used to assess the thickness of retinal nerve fiber layer (RNFL) from 22 AD patients and 22 healthy age-matched controls. The corrected visual acuity and intraocular pressure were measured and the dilated fundus examination and fundus image acquisition were also performed in those subjects. Compared with healthy age-matched controls, the RNFL thickness of AD patients were much thinner ( p < 0.05), especially in supra-retina and infra-retina, while no difference was found in the other retinal area. These changes were also confirmed by the fundus images. In conclusion, retinal nerve degeneration is present in the retina of AD patients and this degeneration is likely localized preferentially to the superior and inferior quadrant.
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ISSN:0304-3940
1872-7972
1872-7972
DOI:10.1016/j.neulet.2010.06.006