Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor?

▶ Basal serum BDNF is not influenced by an 8-week aerobic training program in young sedentary subjects. ▶ A period of 8 weeks detraining does not have an effect on basal peripheral BDNF concentrations. ▶ Both training and detraining do not clearly influence short-term or mid-term memory performance....

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Published in:Neuroscience letters Vol. 486; no. 3; pp. 146 - 149
Main Authors: Goekint, Maaike, Roelands, Bart, De Pauw, Kevin, Knaepen, Kristel, Bos, Inge, Meeusen, Romain
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 17.12.2010
Elsevier
Subjects:
Adolescent
Adult
Aerobic training
BDNF
Biological and medical sciences
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - antagonists & inhibitors
Brain-Derived Neurotrophic Factor - biosynthesis
Brain-Derived Neurotrophic Factor - blood
Cognition - physiology
Detraining
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Memory - physiology
Neurotrophin
Physical Fitness - physiology
Resistance Training - methods
Vertebrates: nervous system and sense organs
Young Adult
Neurotrophin
Detraining
BDNF
Humans
Aerobic training
Human
Brain derived neurotrophic factor
ISSN:0304-3940, 1872-7972, 1872-7972
Online Access:Get full text
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Summary:▶ Basal serum BDNF is not influenced by an 8-week aerobic training program in young sedentary subjects. ▶ A period of 8 weeks detraining does not have an effect on basal peripheral BDNF concentrations. ▶ Both training and detraining do not clearly influence short-term or mid-term memory performance. Brain-derived neurotrophic factor (BDNF) is one of the neurotrophins promoting cognitive function and contributing to neurogenesis and neuroprotection. Available evidence suggests that exercise influences serum BDNF concentrations, but that the effect is transient. The purpose of this study is to determine whether a period of aerobic training, followed by a period of detraining, can influence basal serum BDNF levels in humans. Sixteen young, sedentary subjects were assigned to an experimental group ( n = 9) and a control group ( n = 7). The experimental group performed an aerobic training program during 8 weeks, followed by 8 weeks of detraining, during which subjects returned to their previous, sedentary activity level. The control group remained physically inactive during 16 weeks. In both groups, performance on short-term (Digit Span test) and mid-term memory (Recall of Images) was assessed. Aerobic training significantly increased the VO 2 peak in the experimental group, and these values returned to baseline after 8 weeks of detraining. Basal serum BDNF was not influenced by 8 weeks of aerobic training and detraining did not seem to have an effect on basal peripheral BDNF concentrations. Both training and detraining did not clearly influence short-term memory performance on the Digit Span test and no differences were present between the experimental and control group on the mid-term memory test. Future studies should focus on patient groups and elderly to further investigate the effect of training and detraining on neurotrophic factors and cognitive function, and on the effects of training and detraining on the BDNF response to acute exercise.
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ISSN:0304-3940
1872-7972
1872-7972
DOI:10.1016/j.neulet.2010.09.032