GLUT1 regulates cell glycolysis and proliferation in prostate cancer
Background Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in...
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| Published in: | The Prostate Vol. 78; no. 2; pp. 86 - 94 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Wiley Subscription Services, Inc
01.02.2018
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| ISSN: | 0270-4137, 1097-0045, 1097-0045 |
| Online Access: | Get full text |
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| Abstract | Background
Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in PCa.
Methods
GLUT1 protein levels in prostate cancer tissue and tumor‐adjacent normal tissues were measured and compared. Furthermore, real‐time PCR and Western blot analysis were both used to detect GLUT1 expression levels in different PCa cell lines. Flow cytometry and cell‐based assays, such as a glucose uptake and lactate secretion assay, CCK‐8 assay, and transwell migration and wound healing assay, were used to monitor cancer cell cycle distribution, glycolysis, proliferation, and motility, respectively. Moreover, a mouse tumor xenograft model was used to investigate the role of GLUT1 in tumor progression in vivo.
Results
GLUT1 expression levels are higher in PCa tissues than in tumor‐adjacent normal tissues. The results from real‐time PCR and Western blot analysis revealed a similar increase in the GLUT1 expression levels in PCa cell lines. Moreover, knockdown of GLUT1 inhibits cell glycolysis and proliferation and leads to cell cycle arrest at G2/M phase in the 22RV1 cell line but not in the PC3 cell line. In vivo experiments further confirmed that GLUT1 knockdown inhibits the growth of tumors derived from the 22RV1 cell line. In addition, we also showed that GLUT1 knockdown has no effect on cell migration in vitro.
Conclusions
GLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1‐mediated glycolysis and androgen sensitivity in PCa. |
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| AbstractList | Background Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in PCa. Methods GLUT1 protein levels in prostate cancer tissue and tumor-adjacent normal tissues were measured and compared. Furthermore, real-time PCR and Western blot analysis were both used to detect GLUT1 expression levels in different PCa cell lines. Flow cytometry and cell-based assays, such as a glucose uptake and lactate secretion assay, CCK-8 assay, and transwell migration and wound healing assay, were used to monitor cancer cell cycle distribution, glycolysis, proliferation, and motility, respectively. Moreover, a mouse tumor xenograft model was used to investigate the role of GLUT1 in tumor progression in vivo. Results GLUT1 expression levels are higher in PCa tissues than in tumor-adjacent normal tissues. The results from real-time PCR and Western blot analysis revealed a similar increase in the GLUT1 expression levels in PCa cell lines. Moreover, knockdown of GLUT1 inhibits cell glycolysis and proliferation and leads to cell cycle arrest at G2/M phase in the 22RV1 cell line but not in the PC3 cell line. In vivo experiments further confirmed that GLUT1 knockdown inhibits the growth of tumors derived from the 22RV1 cell line. In addition, we also showed that GLUT1 knockdown has no effect on cell migration in vitro. Conclusions GLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in PCa. Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in PCa.BACKGROUNDGlucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in PCa.GLUT1 protein levels in prostate cancer tissue and tumor-adjacent normal tissues were measured and compared. Furthermore, real-time PCR and Western blot analysis were both used to detect GLUT1 expression levels in different PCa cell lines. Flow cytometry and cell-based assays, such as a glucose uptake and lactate secretion assay, CCK-8 assay, and transwell migration and wound healing assay, were used to monitor cancer cell cycle distribution, glycolysis, proliferation, and motility, respectively. Moreover, a mouse tumor xenograft model was used to investigate the role of GLUT1 in tumor progression in vivo.METHODSGLUT1 protein levels in prostate cancer tissue and tumor-adjacent normal tissues were measured and compared. Furthermore, real-time PCR and Western blot analysis were both used to detect GLUT1 expression levels in different PCa cell lines. Flow cytometry and cell-based assays, such as a glucose uptake and lactate secretion assay, CCK-8 assay, and transwell migration and wound healing assay, were used to monitor cancer cell cycle distribution, glycolysis, proliferation, and motility, respectively. Moreover, a mouse tumor xenograft model was used to investigate the role of GLUT1 in tumor progression in vivo.GLUT1 expression levels are higher in PCa tissues than in tumor-adjacent normal tissues. The results from real-time PCR and Western blot analysis revealed a similar increase in the GLUT1 expression levels in PCa cell lines. Moreover, knockdown of GLUT1 inhibits cell glycolysis and proliferation and leads to cell cycle arrest at G2/M phase in the 22RV1 cell line but not in the PC3 cell line. In vivo experiments further confirmed that GLUT1 knockdown inhibits the growth of tumors derived from the 22RV1 cell line. In addition, we also showed that GLUT1 knockdown has no effect on cell migration in vitro.RESULTSGLUT1 expression levels are higher in PCa tissues than in tumor-adjacent normal tissues. The results from real-time PCR and Western blot analysis revealed a similar increase in the GLUT1 expression levels in PCa cell lines. Moreover, knockdown of GLUT1 inhibits cell glycolysis and proliferation and leads to cell cycle arrest at G2/M phase in the 22RV1 cell line but not in the PC3 cell line. In vivo experiments further confirmed that GLUT1 knockdown inhibits the growth of tumors derived from the 22RV1 cell line. In addition, we also showed that GLUT1 knockdown has no effect on cell migration in vitro.GLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in PCa.CONCLUSIONSGLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in PCa. Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in PCa. GLUT1 protein levels in prostate cancer tissue and tumor-adjacent normal tissues were measured and compared. Furthermore, real-time PCR and Western blot analysis were both used to detect GLUT1 expression levels in different PCa cell lines. Flow cytometry and cell-based assays, such as a glucose uptake and lactate secretion assay, CCK-8 assay, and transwell migration and wound healing assay, were used to monitor cancer cell cycle distribution, glycolysis, proliferation, and motility, respectively. Moreover, a mouse tumor xenograft model was used to investigate the role of GLUT1 in tumor progression in vivo. GLUT1 expression levels are higher in PCa tissues than in tumor-adjacent normal tissues. The results from real-time PCR and Western blot analysis revealed a similar increase in the GLUT1 expression levels in PCa cell lines. Moreover, knockdown of GLUT1 inhibits cell glycolysis and proliferation and leads to cell cycle arrest at G2/M phase in the 22RV1 cell line but not in the PC3 cell line. In vivo experiments further confirmed that GLUT1 knockdown inhibits the growth of tumors derived from the 22RV1 cell line. In addition, we also showed that GLUT1 knockdown has no effect on cell migration in vitro. GLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1-mediated glycolysis and androgen sensitivity in PCa. Background Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and clinical significance of GLUT1 in prostate cancer (PCa) are still unclear. Therefore, in this study, we investigated the role of GLUT1 in PCa. Methods GLUT1 protein levels in prostate cancer tissue and tumor‐adjacent normal tissues were measured and compared. Furthermore, real‐time PCR and Western blot analysis were both used to detect GLUT1 expression levels in different PCa cell lines. Flow cytometry and cell‐based assays, such as a glucose uptake and lactate secretion assay, CCK‐8 assay, and transwell migration and wound healing assay, were used to monitor cancer cell cycle distribution, glycolysis, proliferation, and motility, respectively. Moreover, a mouse tumor xenograft model was used to investigate the role of GLUT1 in tumor progression in vivo. Results GLUT1 expression levels are higher in PCa tissues than in tumor‐adjacent normal tissues. The results from real‐time PCR and Western blot analysis revealed a similar increase in the GLUT1 expression levels in PCa cell lines. Moreover, knockdown of GLUT1 inhibits cell glycolysis and proliferation and leads to cell cycle arrest at G2/M phase in the 22RV1 cell line but not in the PC3 cell line. In vivo experiments further confirmed that GLUT1 knockdown inhibits the growth of tumors derived from the 22RV1 cell line. In addition, we also showed that GLUT1 knockdown has no effect on cell migration in vitro. Conclusions GLUT1 may play an important role in PCa progression via mediating glycolysis and proliferation. Our study also indicated a potential crosstalk between GLUT1‐mediated glycolysis and androgen sensitivity in PCa. |
| Author | Gao, Xin Xiao, Hengjun Yan, Weixin Cui, Yubin Chen, Jun Chen, Zheng Wang, Jun Wen, Xingqiao |
| Author_xml | – sequence: 1 givenname: Hengjun surname: Xiao fullname: Xiao, Hengjun email: hjxiao555@126.com organization: The Third Affiliated Hospital of Sun Yat‐Sen University – sequence: 2 givenname: Jun orcidid: 0000-0001-8074-789X surname: Wang fullname: Wang, Jun organization: The Third Affiliated Hospital of Sun Yat‐Sen University – sequence: 3 givenname: Weixin surname: Yan fullname: Yan, Weixin organization: The Third Affiliated Hospital of Sun Yat‐Sen University – sequence: 4 givenname: Yubin surname: Cui fullname: Cui, Yubin organization: The Third Affiliated Hospital of Sun Yat‐Sen University – sequence: 5 givenname: Zheng surname: Chen fullname: Chen, Zheng organization: The Third Affiliated Hospital of Sun Yat‐Sen University – sequence: 6 givenname: Xin surname: Gao fullname: Gao, Xin organization: The Third Affiliated Hospital of Sun Yat‐Sen University – sequence: 7 givenname: Xingqiao surname: Wen fullname: Wen, Xingqiao organization: Shenzhen Hospital of Southern Medical University – sequence: 8 givenname: Jun surname: Chen fullname: Chen, Jun email: jchen121121@hotmail.com organization: The Third Affiliated Hospital of Sun Yat‐Sen University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29105798$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3322/caac.21338 10.1007/s00432-015-1992-4 10.1126/scitranslmed.3002394 10.1186/s13058-016-0795-0 10.1056/NEJMoa1615869 10.1016/j.eururo.2007.01.061 10.1016/j.ccell.2016.02.018 10.1038/ncomms12240 10.1186/s12885-016-2453-4 10.18632/oncotarget.17445 10.1186/s40170-016-0149-5 10.3322/caac.21332 10.1016/S0140-6736(08)60729-1 10.1158/2159-8290.CD-11-0234 10.1056/NEJMoa1606220 10.1210/en.2014-1260 10.1038/nature13306 10.1074/jbc.270.49.29083 10.1002/cncr.11293 10.1016/j.biocel.2012.08.013 10.1074/jbc.274.29.20281 10.5483/BMBRep.2017.50.3.189 10.1002/jcb.23379 10.2353/ajpath.2009.080596 10.1177/1010428317706215 10.1038/nrc1478 10.1016/j.urology.2009.08.024 10.1016/S1470-2045(14)70361-4 |
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| References | 2010; 75 2017; 8 2004; 4 2007; 51 2009; 174 2016; 18 2011; 3 2014; 155 2017; 377 2016; 16 2014; 510 2003; 97 2016; 142 1995; 270 2016; 4 2017; 50 2016; 7 2012; 2 2012; 113 2017; 39 1999; 274 2014; 15 2016; 375 2017; 18 2016; 29 2012; 44 2008; 371 2016; 66 e_1_2_6_10_1 e_1_2_6_30_1 Barthel A (e_1_2_6_22_1) 1999; 274 e_1_2_6_19_1 Yuan G (e_1_2_6_26_1) 2017; 18 e_1_2_6_13_1 e_1_2_6_14_1 e_1_2_6_11_1 e_1_2_6_12_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 Pedro González‐Menendez P (e_1_2_6_29_1) 2014; 155 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_5_1 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_25_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_28_1 e_1_2_6_27_1 |
| References_xml | – volume: 51 start-page: 1511 year: 2007 end-page: 1520 article-title: Molecular positron emission tomography and PET/CT imaging in urological malignancies publication-title: Eur Urol – volume: 66 start-page: 7 year: 2016 end-page: 30 article-title: Cancer statistics publication-title: CA Cancer J Clin – volume: 15 start-page: 1109 year: 2014 end-page: 1118 article-title: Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial publication-title: Lancet Oncol – volume: 174 start-page: 1544 year: 2009 end-page: 1552 article-title: GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis publication-title: Am J Pathol – volume: 2 start-page: 328 year: 2012 end-page: 343 article-title: Functional metabolic screen identifies 6‐phosphofructo‐2‐kinase/fructose‐ 2,6‐biphosphatase 4 as an important regulator of prostate cancer cell survival publication-title: Cancer Discov – volume: 18 start-page: 131 year: 2016 article-title: The glucose transporter GLUT1 is required for ErbB2‐induced mammary tumorigenesis publication-title: Breast Cancer Res – volume: 29 start-page: 548 year: 2016 end-page: 562 article-title: MTORC1‐dependent metabolic reprogramming underlies escape from glycolysis addiction in cancer cells publication-title: Cancer Cell – volume: 4 start-page: 891 year: 2004 end-page: 899 article-title: Why do cancers have high aerobic glycosis publication-title: Nat Rev Cancer – volume: 377 start-page: 132 year: 2017 end-page: 142 article-title: Follow‐up of prostatectomy versus observation for early prostate cancer publication-title: N Engl J Med – volume: 155 start-page: 3238 year: 2014 end-page: 3250 article-title: Regulation of GLUT transporters by flavonoids in androgen‐sensitive and insensitive prostate cancer cells publication-title: Endocrinology – volume: 18 start-page: 1127 year: 2017 end-page: 1131 article-title: Mir‐150 upregulates glut1 and increases glycolysis in osteosarcoma cells publication-title: Asian Pac J Cancer Prev – volume: 16 start-page: 377 year: 2016 article-title: Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes publication-title: BMC Cancer – volume: 3 start-page: 94ra70 year: 2011 article-title: Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality publication-title: Sci Transl Med – volume: 97 start-page: 2035 year: 2003 end-page: 2042 article-title: Expression and localization of GLUT1 and GLUT12 in prostate carcinoma publication-title: Cancer – volume: 4 start-page: 8 year: 2016 article-title: Molecular characterization of Gleason patterns 3 and 4 prostate cancer using reverse Warburg effect‐associated genes publication-title: Cancer Metab – volume: 8 start-page: 43356 year: 2017 end-page: 43367 article-title: The prognostic value of GLUT1 in cancers: a systematic review and meta‐analysis publication-title: Oncotarget – volume: 270 start-page: 29083 year: 1995 end-page: 29089 article-title: Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter‐1 via distinct Cis‐acting sequences publication-title: J Biol Chem – volume: 39 start-page: 1010428317706215 year: 2017 article-title: MicroRNA‐124 suppresses proliferation and glycolysis in non‐small cell lung cancer cells by targeting AKT‐GLUT1/HKII publication-title: Tumour Biol – volume: 142 start-page: 5 year: 2016 end-page: 16 article-title: Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes publication-title: J Cancer Res Clin Oncol – volume: 50 start-page: 132 year: 2017 end-page: 137 article-title: Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple‐negative breast cancer cells publication-title: BMB Rep – volume: 375 start-page: 1415 year: 2016 end-page: 1424 article-title: 10‐year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer publication-title: N Engl J Med – volume: 44 start-page: 2077 year: 2012 end-page: 2084 article-title: Androgen‐responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile publication-title: Int J Biochem Cell Biol – volume: 66 start-page: 115 year: 2016 end-page: 132 article-title: Cancer statistics in China publication-title: CA Cancer J Clin – volume: 274 start-page: 20186 year: 1999 end-page: 20281 article-title: Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 publication-title: J Biol Chem – volume: 510 start-page: 121 year: 2014 end-page: 125 article-title: Crystal structure of the human glucose transporter GLUT1 publication-title: Nature – volume: 113 start-page: 553 year: 2012 end-page: 562 article-title: Cellular distribution of Glut‐1 and Glut‐5 in benign and malignant human prostate tissue publication-title: J Cell Biochem – volume: 75 start-page: 786 year: 2010 end-page: 792 article-title: Expression and localization of hypoxia proteins in prostate cancer: prognostic implications after radical prostatectomy publication-title: Urology – volume: 371 start-page: 1710 year: 2008 end-page: 1721 article-title: Prostate cancer publication-title: Lancet – volume: 7 start-page: 12240 year: 2016 article-title: Glycolytic regulation of cell rearrangement in angiogenesis publication-title: Nat Commun – ident: e_1_2_6_3_1 doi: 10.3322/caac.21338 – ident: e_1_2_6_30_1 doi: 10.1007/s00432-015-1992-4 – ident: e_1_2_6_15_1 doi: 10.1126/scitranslmed.3002394 – ident: e_1_2_6_25_1 doi: 10.1186/s13058-016-0795-0 – ident: e_1_2_6_6_1 doi: 10.1056/NEJMoa1615869 – ident: e_1_2_6_9_1 doi: 10.1016/j.eururo.2007.01.061 – ident: e_1_2_6_19_1 doi: 10.1016/j.ccell.2016.02.018 – ident: e_1_2_6_18_1 doi: 10.1038/ncomms12240 – ident: e_1_2_6_27_1 doi: 10.1186/s12885-016-2453-4 – ident: e_1_2_6_21_1 doi: 10.18632/oncotarget.17445 – ident: e_1_2_6_12_1 doi: 10.1186/s40170-016-0149-5 – ident: e_1_2_6_2_1 doi: 10.3322/caac.21332 – ident: e_1_2_6_7_1 doi: 10.1016/S0140-6736(08)60729-1 – ident: e_1_2_6_16_1 doi: 10.1158/2159-8290.CD-11-0234 – ident: e_1_2_6_4_1 doi: 10.1056/NEJMoa1606220 – volume: 155 start-page: 3238 year: 2014 ident: e_1_2_6_29_1 article-title: Regulation of GLUT transporters by flavonoids in androgen‐sensitive and insensitive prostate cancer cells publication-title: Endocrinology doi: 10.1210/en.2014-1260 – ident: e_1_2_6_8_1 doi: 10.1038/nature13306 – ident: e_1_2_6_23_1 doi: 10.1074/jbc.270.49.29083 – ident: e_1_2_6_10_1 doi: 10.1002/cncr.11293 – ident: e_1_2_6_28_1 doi: 10.1016/j.biocel.2012.08.013 – volume: 274 start-page: 20186 year: 1999 ident: e_1_2_6_22_1 article-title: Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 publication-title: J Biol Chem doi: 10.1074/jbc.274.29.20281 – ident: e_1_2_6_14_1 doi: 10.5483/BMBRep.2017.50.3.189 – ident: e_1_2_6_11_1 doi: 10.1002/jcb.23379 – ident: e_1_2_6_13_1 doi: 10.2353/ajpath.2009.080596 – ident: e_1_2_6_24_1 doi: 10.1177/1010428317706215 – volume: 18 start-page: 1127 year: 2017 ident: e_1_2_6_26_1 article-title: Mir‐150 upregulates glut1 and increases glycolysis in osteosarcoma cells publication-title: Asian Pac J Cancer Prev – ident: e_1_2_6_17_1 doi: 10.1038/nrc1478 – ident: e_1_2_6_20_1 doi: 10.1016/j.urology.2009.08.024 – ident: e_1_2_6_5_1 doi: 10.1016/S1470-2045(14)70361-4 |
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Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function... Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function and... Background Glucose transporter 1 (GLUT1) plays a critical role in tumorigenesis and tumor progression in multiple cancer types. However, the specific function... |
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| SubjectTerms | Animals Cell adhesion & migration Cell cycle Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation - genetics Cholecystokinin Disease Models, Animal Flow cytometry Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Glucose transporter glucose transporter 1 Glucose Transporter Type 1 - genetics GLUT1 protein Glycolysis Glycolysis - physiology Humans Lactic acid Male Mice migration proliferation Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Secretion Studies Tumorigenesis Wound healing Xenografts |
| Title | GLUT1 regulates cell glycolysis and proliferation in prostate cancer |
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