The role of platelet MyD88 in host response during gram‐negative sepsis

Summary Background Beside their role in hemostasis, platelets serve as sentinel cells in host defense during infection. In sepsis, platelets have been implicated in both beneficial (antibacterial) and detrimental responses (thrombosis and organ damage). Toll‐like receptors and their common adaptor,...

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Veröffentlicht in:	Journal of thrombosis and haemostasis Jg. 13; H. 9; S. 1709 - 1720
Hauptverfasser:	Stoppelaar, S. F., Claushuis, T. A. M., Jansen, M. P. B., Hou, B., Roelofs, J. J. T. H., Veer, C., Poll, T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Limited 01.09.2015
Schlagworte:	Animals Bacteremia - complications Bacteremia - immunology Bacteremia - microbiology Bacterial Load Blood Coagulation Blood Platelets - immunology Chemokine CCL2 - blood Endothelium, Vascular - physiopathology Extracellular Traps Female Klebsiella Infections - blood Klebsiella Infections - immunology Klebsiella Infections - therapy Klebsiella pneumoniae - immunology Liver - pathology Lung - pathology Male Mice Mice, Inbred C57BL Mice, Knockout myeloid differentiation factor 88 Myeloid Differentiation Factor 88 - deficiency Myeloid Differentiation Factor 88 - physiology Platelet Transfusion platelets pneumonia Pneumonia, Bacterial - blood Pneumonia, Bacterial - complications Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - pathology Rodents Sepsis Sepsis - blood Sepsis - etiology Sepsis - immunology Sepsis - therapy Single-Blind Method Spleen - pathology Toll-Like Receptors - blood Toll‐like receptors Tumor Necrosis Factor-alpha - analysis Toll-like receptors myeloid differentiation factor 88 pneumonia mice platelets sepsis
ISSN:	1538-7933, 1538-7836, 1538-7836
Online-Zugang:	Volltext
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