EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long‐chain acylcarnitines

Elevated levels of fatty acid‐derived long‐chain acylcarnitines are detrimental to cardiac health, primarily because of their adverse effects on mitochondrial function and key metabolic pathways in the heart. While trans‐fatty acids are considered harmful and omega‐3 polyunsaturated fatty acids (PUF...

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Bibliographic Details
Published in:	BioFactors (Oxford) Vol. 51; no. 2; pp. e70014 - n/a
Main Authors:	Liepinsh, Edgars, Gukalova, Baiba, Krims‐Davis, Kristaps, Kuka, Janis, Leduskrasta, Aiga, Korzh, Stanislava, Vilskersts, Reinis, Makrecka‐Kuka, Marina, Konrade, Ilze, Dambrova, Maija
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.03.2025
Subjects:	Animals Cardiotoxicity Carnitine - analogs & derivatives Carnitine - pharmacology Carnitine - toxicity Cell Survival - drug effects Docosahexaenoic Acids - pharmacology Docosahexaenoic Acids - toxicity Eicosapentaenoic Acid - analogs & derivatives Eicosapentaenoic Acid - pharmacology heart Insulin - metabolism mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism MUFA Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism omega‐3 PUFA Rats Signal Transduction - drug effects trans fatty acids unsaturated trans fatty acids omega‐3 PUFA mitochondria MUFA heart unsaturated
ISSN:	0951-6433, 1872-8081, 1872-8081
Online Access:	Get full text
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